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KLC1 kinesin light chain 1 [ Homo sapiens (human) ]

Gene ID: 3831, updated on 5-Mar-2024

Summary

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Official Symbol
KLC1provided by HGNC
Official Full Name
kinesin light chain 1provided by HGNC
Primary source
HGNC:HGNC:6387
See related
Ensembl:ENSG00000126214 MIM:600025; AllianceGenome:HGNC:6387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLC; KNS2; KNS2A
Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See KLC1 in Genome Data Viewer
Location:
14q32.33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103629211..103701544)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97865285..97937591)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104095548..104167881)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 68, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr14:104054857-104055031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104056621-104057122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104057123-104057622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6161 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6162 Neighboring gene uncharacterized LOC105370688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104106328-104106828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6168 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104140157-104140656 Neighboring gene MPRA-validated peak2255 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172251-104172810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172811-104173372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104180589-104181274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104184511-104185021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104187639-104188139 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104209353-104210134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6175 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104260985-104261486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104261487-104261986 Neighboring gene small nucleolar RNA SNORD51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Morihara T, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24497505, Free PMC Article
  2. Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population. Zhang L, et al. PLoS One, 2013. PMID 23776437, Free PMC Article
  3. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. Szolnoki Z, et al. J Stroke Cerebrovasc Dis, 2009 Sep-Oct. PMID 19717019
  4. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. Szolnoki Z, et al. Clin Biochem, 2009 May. PMID 19046961
  5. Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Andersson ME, et al. Mol Vis, 2007 Jun 27. PMID 17653041, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
    Title: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
  2. Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
    Title: Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
  3. LMTK2 binds to KLC1 to direct axonal transport of p35 and its loss may contribute to Alzheimer's disease.
    Title: LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
  4. TGF-beta mediated pro-invasive activity was found to be dependent on KIF5B expression. In contrast, the epithelial differentiation factor and EMT suppressor prolactin (PRL) was found to repress KIF5B gene expression and KIF5B-Snail1 nuclear accumulation, but enhanced KLC1 gene expression and KIF5B-KLC1 interaction.
    Title: A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
  5. these studies demonstrate that kinesin 1 regulates ciliogenesis through CCDC28B
    Title: Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
  6. extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1.
    Title: Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).
  7. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding
    Title: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
  8. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients.
    Title: A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC.
  9. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
    Title: BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
  10. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development.
    Title: The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: COA8

Homology

Clone Names

  • MGC15245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin light chain 1
Names
kinesin 2 60/70kDa
medulloblastoma antigen MU-MB-2.50
NP_001123579.1
NP_001381761.1
NP_001381762.1
NP_001381763.1
NP_001381764.1
NP_001381765.1
NP_001381766.1
NP_001381767.1
NP_001381768.1
NP_001381769.1
NP_001381770.1
NP_001381771.1
NP_001381772.1
NP_001381773.1
NP_001381774.1
NP_001381775.1
NP_001381776.1
NP_001381777.1
NP_001381778.1
NP_001381779.1
NP_001381780.1
NP_001381781.1
NP_001381782.1
NP_001381783.1
NP_001381784.1
NP_001381785.1
NP_001381786.1
NP_001381787.1
NP_001381788.1
NP_001381789.1
NP_005543.2
NP_891553.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012307.1 RefSeqGene

    Range
    5024..77357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130107.2 → NP_001123579.1  kinesin light chain 1 isoform 3

    See identical proteins and their annotated locations for NP_001123579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, also known as D.
    Source sequence(s)
    BC008881, BK001163, BK001164, BM988840, BP274336
    Consensus CDS
    CCDS45168.1
    UniProtKB/TrEMBL
    Q7RTQ2
    Related
    ENSP00000414982.2, ENST00000452929.6
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  2. NM_001394832.1 → NP_001381761.1  kinesin light chain 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ4
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  3. NM_001394833.1 → NP_001381762.1  kinesin light chain 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTP8
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  4. NM_001394834.1 → NP_001381763.1  kinesin light chain 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ4
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  5. NM_001394835.1 → NP_001381764.1  kinesin light chain 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ0
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  6. NM_001394836.1 → NP_001381765.1  kinesin light chain 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ2
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  7. NM_001394837.1 → NP_001381766.1  kinesin light chain 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91953.1
    UniProtKB/TrEMBL
    Q7RTQ4
    Related
    ENSP00000334523.6, ENST00000334553.11
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  8. NM_001394838.1 → NP_001381767.1  kinesin light chain 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91952.1
    UniProtKB/TrEMBL
    Q7RTP8
    Related
    ENSP00000246489.7, ENST00000246489.11
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  9. NM_001394839.1 → NP_001381768.1  kinesin light chain 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ2
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  10. NM_001394840.1 → NP_001381769.1  kinesin light chain 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91948.1
    UniProtKB/TrEMBL
    G3V5R9, Q7RTQ4
    Related
    ENSP00000452481.1, ENST00000555836.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  11. NM_001394841.1 → NP_001381770.1  kinesin light chain 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91947.1
    UniProtKB/TrEMBL
    Q7RTQ0
    Related
    ENSP00000334618.7, ENST00000347839.10
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  12. NM_001394842.1 → NP_001381771.1  kinesin light chain 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ2
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:296 → 324
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:295 → 369
    TPR_12; Tetratricopeptide repeat

  13. NM_001394843.1 → NP_001381772.1  kinesin light chain 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ2
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  14. NM_001394844.1 → NP_001381773.1  kinesin light chain 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91949.1
    UniProtKB/TrEMBL
    G3V3H3, Q7RTQ2
    Related
    ENSP00000451242.1, ENST00000554280.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  15. NM_001394845.1 → NP_001381774.1  kinesin light chain 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ1
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  16. NM_001394846.1 → NP_001381775.1  kinesin light chain 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    B5BU63
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  17. NM_001394847.1 → NP_001381776.1  kinesin light chain 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ2
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  18. NM_001394848.1 → NP_001381777.1  kinesin light chain 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    B5BU63
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  19. NM_001394849.1 → NP_001381778.1  kinesin light chain 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ7
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  20. NM_001394850.1 → NP_001381779.1  kinesin light chain 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91946.1
    UniProtKB/TrEMBL
    F8W6L3, Q7RTQ9
    Related
    ENSP00000369377.3, ENST00000380038.7
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  21. NM_001394851.1 → NP_001381780.1  kinesin light chain 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    B5BU63
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  22. NM_001394852.1 → NP_001381781.1  kinesin light chain 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91950.1
    UniProtKB/TrEMBL
    B5BU63
    Related
    ENSP00000450648.1, ENST00000557450.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  23. NM_001394853.1 → NP_001381782.1  kinesin light chain 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ9
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  24. NM_001394854.1 → NP_001381783.1  kinesin light chain 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ7
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  25. NM_001394855.1 → NP_001381784.1  kinesin light chain 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ9
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  26. NM_001394856.1 → NP_001381785.1  kinesin light chain 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ9
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  27. NM_001394857.1 → NP_001381786.1  kinesin light chain 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91945.1
    UniProtKB/TrEMBL
    G5E9S8, Q7RTQ9
    Related
    ENSP00000412693.4, ENST00000445352.8
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  28. NM_001394858.1 → NP_001381787.1  kinesin light chain 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ9
    Related
    ENSP00000488938.1, ENST00000634686.1
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  29. NM_001394859.1 → NP_001381788.1  kinesin light chain 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    UniProtKB/TrEMBL
    Q7RTQ9
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  30. NM_001394860.1 → NP_001381789.1  kinesin light chain 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Consensus CDS
    CCDS91951.1
    UniProtKB/TrEMBL
    G3V2E7, Q7RTQ7
    Related
    ENSP00000450617.1, ENST00000557575.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

  31. NM_005552.5 → NP_005543.2  kinesin light chain 1 isoform 1

    See identical proteins and their annotated locations for NP_005543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' sequence, as compared to variant 3. The resulting isoform (1, also known as C) has a shorter and distinct C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL049840, BC008881, DA501532
    Consensus CDS
    CCDS32165.1
    UniProtKB/TrEMBL
    Q7RTQ7
    Related
    ENSP00000374394.3, ENST00000389744.8
    Conserved Domains (3) summary
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35 → 149
    SMC_N; RecF/RecN/SMC N terminal domain

  32. NM_182923.4 → NP_891553.2  kinesin light chain 1 isoform 2

    See identical proteins and their annotated locations for NP_891553.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 3. The resulting isoform (2, also known as H) has a shorter and distinct C-terminus when compared to isoform 3.
    Source sequence(s)
    AL139300, BM988840, BP274336, L04733
    Consensus CDS
    CCDS41996.1
    UniProtKB/Swiss-Prot
    A6NF62, F8VTM4, Q07866, Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ3, Q7RTQ5, Q7RTQ6, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62
    UniProtKB/TrEMBL
    B5BU63
    Related
    ENSP00000341154.6, ENST00000348520.10
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297 → 325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296 → 370
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103629211..103701544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97865285..97937591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07866.2 GenPept UniProtKB/Swiss-Prot:Q07866

Gene LinkOut

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