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JAK1 Janus kinase 1 [ Homo sapiens (human) ]

Gene ID: 3716, updated on 11-Apr-2024

Summary

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Official Symbol
JAK1provided by HGNC
Official Full Name
Janus kinase 1provided by HGNC
Primary source
HGNC:HGNC:6190
See related
Ensembl:ENSG00000162434 MIM:147795; AllianceGenome:HGNC:6190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JTK3; AIIDE; JAK1A; JAK1B
Summary
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression
Ubiquitous expression in lymph node (RPKM 51.3), fat (RPKM 49.8) and 25 other tissues See more
Orthologs
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Genomic context

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See JAK1 in Genome Data Viewer
Location:
1p31.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (64833229..65067746, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (64711228..64945755, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (65298912..65533429, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene uncharacterized LOC124904195 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:65037847-65038552 Neighboring gene microRNA 4794 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:65129441-65129616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 957 Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1129 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:65312286-65313485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:65326691-65327236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1134 Neighboring gene Sharpr-MPRA regulatory region 6411 Neighboring gene NDUFA4, mitochondrial complex associated pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 958 Neighboring gene Sharpr-MPRA regulatory region 2453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1140 Neighboring gene long intergenic non-protein coding RNA 1359 Neighboring gene solute carrier family 2 member 3 pseudogene 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:65491678-65492495 Neighboring gene RNA, U6 small nuclear 1176, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 963 Neighboring gene ribosomal protein S24 pseudogene Neighboring gene microRNA 101-1 Neighboring gene microRNA 3671 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. JAK1 Inhibition to Treat Crohn's Disease. Abreu MT. N Engl J Med, 2023 May 25. PMID 37224204
  2. JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling. Grant AH, et al. Int J Mol Sci, 2023 Apr 6. PMID 37047778, Free PMC Article
  3. Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. Biggs CM, et al. JCI Insight, 2022 Dec 22. PMID 36546480, Free PMC Article
  4. JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway. Lin Q, et al. Cell Commun Signal, 2022 Nov 14. PMID 36376931, Free PMC Article
  5. Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria. Daza-Cajigal V, et al. Front Immunol, 2022. PMID 36159783, Free PMC Article

See all (471) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
    Title: Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
  2. Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
    Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
  3. CD146[+]CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
    Title: CD146(+)CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
  4. Inhibiting JAK1, not NF-kappaB, reverses the effect of pro-inflammatory cytokines on engineered human ligament function.
    Title: Inhibiting JAK1, not NF-κB, reverses the effect of pro-inflammatory cytokines on engineered human ligament function.
  5. JAK1 promotes HDV replication and is a potential target for antiviral therapy.
    Title: JAK1 promotes HDV replication and is a potential target for antiviral therapy.
  6. WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
    Title: WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
  7. METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.
    Title: METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.
  8. RARgamma promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
    Title: RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
  9. Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients.
    Title: Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients.
  10. JAK1 Inhibition to Treat Crohn's Disease.
    Title: JAK1 Inhibition to Treat Crohn's Disease.
Submit: New GeneRIF Correction See all GeneRIFs (224)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Autoinflammation, immune dysregulation, and eosinophilia
MedGen: C5436572 OMIM: 618999 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of Janus kinase 1 (JAK1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed
Knockdown of Janus kinase 1 (JAK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of Janus kinase 1 (JAK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat Knockdown of JAK1 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed
tat HIV-1 Tat-mediated activation of PIK3R1 hypothetically induces the modulation of JAK1 PubMed
matrix gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CCR5 chemokine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth hormone receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-11-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-15-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-2-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in interleukin-4-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-6-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in interleukin-9-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of homotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in type II interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type II interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in type II interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in type III interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome TAS
Traceable Author Statement
more info
  
is_active_in extrinsic component of cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK1
NP_001307852.1
NP_001308781.1
NP_001308782.1
NP_001308783.1
NP_001308784.1
NP_001308785.1
NP_001308786.1
NP_002218.2
XP_047275630.1
XP_047275631.1
XP_047275632.1
XP_047275633.1
XP_054192401.1
XP_054192402.1
XP_054192403.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023402.2 RefSeqGene

    Range
    106198..239518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1398

mRNA and Protein(s)

  1. NM_001320923.2 → NP_001307852.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093427, AK314257, BC062431, BC132729
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000514243.1, ENST00000699262.1
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  2. NM_001321852.2 → NP_001308781.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates from an upstream promoter compared to variant 1.
    Source sequence(s)
    AC093427, AL357078
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000500745.2, ENST00000672751.2
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  3. NM_001321853.2 → NP_001308782.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) initiates from an upstream promoter compared to variant 1.
    Source sequence(s)
    AC093427, AL357078, AL606517
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000499900.1, ENST00000672434.2
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  4. NM_001321854.2 → NP_001308783.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) initiates from an upstream promoter compared to variant 1.
    Source sequence(s)
    AC093427, AL357078
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000514291.1, ENST00000699312.1
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  5. NM_001321855.2 → NP_001308784.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093427, AL606517
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000499884.1, ENST00000672247.2
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  6. NM_001321856.2 → NP_001308785.1  tyrosine-protein kinase JAK1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093427, AL606517
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000500296.1, ENST00000672179.2
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  7. NM_001321857.2 → NP_001308786.1  tyrosine-protein kinase JAK1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093427, AL606517
    Consensus CDS
    CCDS90968.1
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39, A0A8V8TPQ9
    Related
    ENSP00000514241.1, ENST00000699260.1
    Conserved Domains (7) summary
    cd05079
    Location:869 → 1152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:874 → 1148
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:582 → 845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:582 → 844
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 526
    SH2; Src homology 2 (SH2) domain

  8. NM_002227.4 → NP_002218.2  tyrosine-protein kinase JAK1 isoform 1

    See identical proteins and their annotated locations for NP_002218.2

    Status: REVIEWED

    Source sequence(s)
    AB209057, AC093427, AL606517, BC009079
    Consensus CDS
    CCDS41346.1
    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
    UniProtKB/TrEMBL
    A0A0A0N0M2, A0A5F9ZI39
    Related
    ENSP00000343204.4, ENST00000342505.5
    Conserved Domains (7) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00219
    Location:875 → 1149
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam07714
    Location:583 → 845
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    64833229..65067746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419676.1 → XP_047275632.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TPQ9

  2. XM_047419677.1 → XP_047275633.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TPQ9

  3. XM_047419675.1 → XP_047275631.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26

  4. XM_047419674.1 → XP_047275630.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    64711228..64945755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336427.1 → XP_054192402.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TPQ9

  2. XM_054336428.1 → XP_054192403.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TPQ9

  3. XM_054336426.1 → XP_054192401.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/Swiss-Prot
    P23458, Q59GQ2, Q9UD26
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23458.2 GenPept UniProtKB/Swiss-Prot:P23458

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