IL13RA1 interleukin 13 receptor subunit alpha 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL13RA1provided by HGNC
Official Full Name: interleukin 13 receptor subunit alpha 1provided by HGNC
Primary source: HGNC:HGNC:5974
See related: Ensembl:ENSG00000131724 MIM:300119; AllianceGenome:HGNC:5974
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NR4; CT19; CD213A1; IL-13Ra
Summary: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (118727606..118805228)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (117105336..117182975)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (117861569..117928496)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
Title: Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.
Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
Title: Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
Title: IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.
High IL13RA1 expression is associated with Invasive breast Cancer.
Title: Elevated Interleukin-13 Receptor Alpha 1 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Breast Cancer.
in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
Title: New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
Title: IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.
sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism.
Title: Soluble interleukin-13rα1: a circulating regulator of glucose.
these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes
Title: MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1.
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair.
Title: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.
required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4
Title: The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of interleukin 13 receptor, alpha 1 gene (IL13RA1) in mammary epithelial cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93401 (e-PCR)
- UniSTS:91917

RH102960 (e-PCR)
- UniSTS:97294

G20227 (e-PCR)
- UniSTS:61749

A005A40 (e-PCR)
- UniSTS:61750

SHGC-34461 (e-PCR)
- UniSTS:68730

DXS7580 (e-PCR)
- UniSTS:154237

RH47729 (e-PCR)
- UniSTS:49551

G44334 (e-PCR)
- UniSTS:95121

IL13RA1_2422 (e-PCR)
- UniSTS:280777

STS-T76997 (e-PCR)
- UniSTS:57556

RH17875 (e-PCR)
- UniSTS:54780

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-13 receptor complex	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-1

Names: CD213a1 antigen; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL13 receptor alpha-1 chain; cancer/testis antigen 19; interleukin 13 receptor, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012841.1 RefSeqGene

Range

5011..71938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001560.3 → NP_001551.1 interleukin-13 receptor subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_001551.1

Status: REVIEWED

Source sequence(s)

AL391280

Consensus CDS

CCDS14573.1

UniProtKB/Swiss-Prot

O95646, P78552, Q5JSL4, Q99656, Q9UDY5

UniProtKB/TrEMBL

Q8WX08, Q96BB4

Related

ENSP00000360730.3, ENST00000371666.8

Conserved Domains (2) summary

cd00063
Location:228 → 336

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:131 → 224

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding