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GPR141 G protein-coupled receptor 141 [ Homo sapiens (human) ]

Gene ID: 353345, updated on 5-Mar-2024

Summary

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Official Symbol
GPR141provided by HGNC
Official Full Name
G protein-coupled receptor 141provided by HGNC
Primary source
HGNC:HGNC:19997
See related
Ensembl:ENSG00000187037 MIM:609045; AllianceGenome:HGNC:19997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR13
Summary
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in bone marrow (RPKM 2.2), appendix (RPKM 0.5) and 10 other tissues See more
Orthologs
all
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Genomic context

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See GPR141 in Genome Data Viewer
Location:
7p14.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (37683766..37743835)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (37824251..37884325)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (37723369..37783437)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 1 Neighboring gene uncharacterized LOC124900242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37569874-37570374 Neighboring gene Sharpr-MPRA regulatory region 7218 Neighboring gene NECAP endocytosis associated 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25859 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:37745514-37745731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37843212-37843712 Neighboring gene G protein-coupled receptor 141B, pseudogene Neighboring gene CDCA3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis. Parija M, et al. Oncotarget, 2023 May 19. PMID 37204251, Free PMC Article
  2. A genome-wide association study of periodontitis in a Japanese population. Shimizu S, et al. J Dent Res, 2015 Apr. PMID 25672891
  3. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  4. Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. Zouboulis CC, et al. J Eur Acad Dermatol Venereol, 2020 Jul. PMID 32031713
  5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxysterol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 141
Names
G-protein coupled receptor PGR13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329993.2 → NP_001316922.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001329994.2 → NP_001316923.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001381946.1 → NP_001368875.1  probable G-protein coupled receptor 141

    Status: REVIEWED

    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Related
    ENSP00000334540.1, ENST00000334425.2
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_181791.3 → NP_861456.1  probable G-protein coupled receptor 141

    See identical proteins and their annotated locations for NP_861456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 all encode the same protein.
    Source sequence(s)
    AC083860, AC083865
    Consensus CDS
    CCDS5451.1
    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Related
    ENSP00000390410.1, ENST00000447769.1
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    37683766..37743835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515374.4 → XP_011513676.1  probable G-protein coupled receptor 141 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:150 → 393
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. XM_011515375.4 → XP_011513677.1  probable G-protein coupled receptor 141 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:138 → 381
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_047420331.1 → XP_047276287.1  probable G-protein coupled receptor 141 isoform X5

  4. XM_011515389.3 → XP_011513691.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513691.1

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_047420330.1 → XP_047276286.1  probable G-protein coupled receptor 141 isoform X3

  6. XM_017012163.3 → XP_016867652.1  probable G-protein coupled receptor 141 isoform X4

    Conserved Domains (1) summary
    pfam00001
    Location:66 → 309
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  7. XM_047420332.1 → XP_047276288.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3

  8. XM_011515388.3 → XP_011513690.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513690.1

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  9. XM_011515383.4 → XP_011513685.1  probable G-protein coupled receptor 141 isoform X6

    Conserved Domains (1) summary
    pfam00001
    Location:43 → 286
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  10. XM_011515386.3 → XP_011513688.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513688.1

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  11. XM_011515385.3 → XP_011513687.1  probable G-protein coupled receptor 141 isoform X7

    See identical proteins and their annotated locations for XP_011513687.1

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Conserved Domains (2) summary
    cd14964
    Location:18 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    37824251..37884325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358134.1 → XP_054214109.1  probable G-protein coupled receptor 141 isoform X1

  2. XM_054358135.1 → XP_054214110.1  probable G-protein coupled receptor 141 isoform X2

  3. XM_054358138.1 → XP_054214113.1  probable G-protein coupled receptor 141 isoform X5

  4. XM_054358143.1 → XP_054214118.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3

  5. XM_054358136.1 → XP_054214111.1  probable G-protein coupled receptor 141 isoform X3

  6. XM_054358137.1 → XP_054214112.1  probable G-protein coupled receptor 141 isoform X4

  7. XM_054358142.1 → XP_054214117.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3

  8. XM_054358144.1 → XP_054214119.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3

  9. XM_054358139.1 → XP_054214114.1  probable G-protein coupled receptor 141 isoform X6

  10. XM_054358141.1 → XP_054214116.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3

  11. XM_054358140.1 → XP_054214115.1  probable G-protein coupled receptor 141 isoform X7

    UniProtKB/Swiss-Prot
    A4D1X7, Q0VAR5, Q7Z602, Q86SP3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z602.1 GenPept UniProtKB/Swiss-Prot:Q7Z602

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