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KLRG2 killer cell lectin like receptor G2 [ Homo sapiens (human) ]

Gene ID: 346689, updated on 5-Mar-2024

Summary

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Official Symbol
KLRG2provided by HGNC
Official Full Name
killer cell lectin like receptor G2provided by HGNC
Primary source
HGNC:HGNC:24778
See related
Ensembl:ENSG00000188883 AllianceGenome:HGNC:24778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLEC15B
Summary
Predicted to enable carbohydrate binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 1.5), thyroid (RPKM 1.0) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139427098..139483673, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140740393..140796968, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139137436..139168419, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139026059-139026626 Neighboring gene FMC1-LUC7L2 readthrough Neighboring gene tRNA-Arg (anticodon CCT) 4-1 Neighboring gene LUC7 like 2, pre-mRNA splicing factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18695 Neighboring gene formation of mitochondrial complex V assembly factor 1 homolog Neighboring gene MPRA-validated peak6781 silencer Neighboring gene uncharacterized LOC100129148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139111514-139112150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139136252-139137140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139137141-139138027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139138916-139139802 Neighboring gene RNA, U6 small nuclear 911, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:139146664-139147433 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139150055-139150776 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139152221-139152942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:139153665-139154386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139154387-139155106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164064-139164564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139164565-139165065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26763 Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene C-type lectin domain family 2 member L Neighboring gene ERH pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. Liu X, et al. Prostate, 2011 May 15. PMID 20945404, Free PMC Article
  2. CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Albert MC, et al. Cell Death Dis, 2020 Sep 10. PMID 32913203, Free PMC Article
  3. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. Adhikari H, et al. Nat Commun, 2018 Sep 7. PMID 30194290, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic variants in the gene KLRG2 may affect Gleason score at diagnosis and hence the aggressiveness of prostate cancer.
    Title: Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44186, MGC131846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily G member 2
Names
C-type lectin domain family 15 member B
killer cell lectin-like receptor subfamily G, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198508.4 → NP_940910.1  killer cell lectin-like receptor subfamily G member 2

    See identical proteins and their annotated locations for NP_940910.1

    Status: VALIDATED

    Source sequence(s)
    AC005531
    Consensus CDS
    CCDS5854.1
    UniProtKB/Swiss-Prot
    A4D1S0, Q2NL79, Q6ZTV6
    Related
    ENSP00000339356.4, ENST00000340940.5
    Conserved Domains (2) summary
    cd03593
    Location:293 → 406
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    cl26386
    Location:5 → 214
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    139427098..139483673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516141.3 → XP_011514443.1  killer cell lectin-like receptor subfamily G member 2 isoform X2

    Conserved Domains (1) summary
    smart00034
    Location:293 → 328
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  2. XM_005250311.4 → XP_005250368.1  killer cell lectin-like receptor subfamily G member 2 isoform X3

    Conserved Domains (1) summary
    smart00034
    Location:293 → 328
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  3. XM_011516140.3 → XP_011514442.1  killer cell lectin-like receptor subfamily G member 2 isoform X1

    Conserved Domains (1) summary
    smart00034
    Location:293 → 328
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    140740393..140796968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358116.1 → XP_054214091.1  killer cell lectin-like receptor subfamily G member 2 isoform X2

  2. XM_054358117.1 → XP_054214092.1  killer cell lectin-like receptor subfamily G member 2 isoform X3

  3. XM_054358115.1 → XP_054214090.1  killer cell lectin-like receptor subfamily G member 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4D1S0.3 GenPept UniProtKB/Swiss-Prot:A4D1S0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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