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IFI35 interferon induced protein 35 [ Homo sapiens (human) ]

Gene ID: 3430, updated on 5-Mar-2024

Summary

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Official Symbol
IFI35provided by HGNC
Official Full Name
interferon induced protein 35provided by HGNC
Primary source
HGNC:HGNC:5399
See related
Ensembl:ENSG00000068079 MIM:600735; AllianceGenome:HGNC:5399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFP35
Summary
Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of signal transduction. Located in several cellular components, including cytosol; extracellular space; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17q21.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43006784..43014456)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43864072..43871742)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41158801..41166473)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8549 Neighboring gene RUN domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41142673-41143174 Neighboring gene uncharacterized LOC124904006 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:41149993-41151192 Neighboring gene ribosomal protein L27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12233 Neighboring gene vesicle amine transport 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8550 Neighboring gene Rho family GTPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review. De Masi R, et al. Biology (Basel), 2021 Dec 14. PMID 34943240, Free PMC Article
  2. IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis. De Masi R, et al. Life Sci, 2020 Oct 15. PMID 32781067
  3. The role of IFI35 in lupus nephritis and related mechanisms. Zhang L, et al. Mod Rheumatol, 2017 Nov. PMID 28064541
  4. IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. Tan J, et al. J Virol, 2008 May. PMID 18305040, Free PMC Article
  5. Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1. Brown MA, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753812, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
  2. IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
    Title: IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
  3. inhibits both endothelial cell proliferation and migration by inhibiting the NF-kappaB/p65 pathway; functionally interacts with Nmi through its NID1 domain
    Title: Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.
  4. IFI35 enhances proliferation of mesangial cells and is regulated by MBD2 in lupus nephritis.
    Title: The role of IFI35 in lupus nephritis and related mechanisms.
  5. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
    Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
  6. Study found that TLR3 signaling induces the expression of IFI35, and IFI35 negatively regulates IFN-beta-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells. This suggests that IFI35 expressed in astrocytes may play an important role in regulating the innate immune system in astrocytoma cells.
    Title: Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.
  7. Activation of TLR3 by poly IC induces the IFI35 expression in Mesangial Cells. Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD.
    Title: Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.
  8. Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response
    Title: Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.
  9. Knockdown of IFP35 expression abolished pEGFP-N1-2C and pEGFP-N1-Nmi-induced activation of type I interferon promoters.
    Title: A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C.
  10. IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
    Title: Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 35 (IFI35) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI35, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI35 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced 35 kDa protein
Names
IFP 35
ifi-35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330230.2 → NP_001317159.1  interferon-induced 35 kDa protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA827287, AC055866
    Consensus CDS
    CCDS82134.1
    UniProtKB/Swiss-Prot
    C9JGX1, P80217, Q92984, Q99537, Q9BV98
    Related
    ENSP00000394579.3, ENST00000415816.7

  2. NM_005533.5 → NP_005524.2  interferon-induced 35 kDa protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA740882, AA832092, BC001356, BU571030
    Consensus CDS
    CCDS11450.1
    UniProtKB/Swiss-Prot
    P80217
    Related
    ENSP00000395590.2, ENST00000438323.2
    Conserved Domains (2) summary
    pfam07292
    Location:183 → 268
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:9 → 80
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43006784..43014456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024584.2 → XP_016880073.1  interferon-induced 35 kDa protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43864072..43871742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315946.1 → XP_054171921.1  interferon-induced 35 kDa protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80217.5 GenPept UniProtKB/Swiss-Prot:P80217

Gene LinkOut

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