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NEK5 NIMA related kinase 5 [ Homo sapiens (human) ]

Gene ID: 341676, updated on 3-Apr-2024

Summary

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Official Symbol
NEK5provided by HGNC
Official Full Name
NIMA related kinase 5provided by HGNC
Primary source
HGNC:HGNC:7748
See related
Ensembl:ENSG00000197168 MIM:616731; AllianceGenome:HGNC:7748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity and positive regulation of striated muscle cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 3.0), lung (RPKM 0.4) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
13q14.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52033611..52129073, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51248427..51343906, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52607747..52703209, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase copper transporting beta Neighboring gene fatty acid binding protein 5 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 15635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7786 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene UTP14C small subunit processome component Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52653033-52653791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52653792-52654549 Neighboring gene Sharpr-MPRA regulatory region 10224 Neighboring gene Sharpr-MPRA regulatory region 2352 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:52696487-52696693 Neighboring gene uncharacterized LOC101929657 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:52706487-52707686 Neighboring gene uncharacterized LOC124903176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5382 Neighboring gene NIMA related kinase 3 Neighboring gene Sharpr-MPRA regulatory region 2809 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 5 Neighboring gene thrombospondin type 1 domain containing 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach. de Castro Ferezin C, et al. Cell Commun Signal, 2022 Dec 22. PMID 36550548, Free PMC Article
  2. NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells. Matossian MD, et al. Breast Cancer Res Treat, 2021 Aug. PMID 34196902
  3. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review. Matossian MD, et al. Curr Med Chem, 2021. PMID 33749548
  4. Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. Prosser SL, et al. J Cell Biol, 2015 May 11. PMID 25963817, Free PMC Article
  5. Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration. Melo Hanchuk TD, et al. Cell Signal, 2015 Jun. PMID 25725288

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach.
    Title: Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach.
  2. NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance.
    Title: NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance.
  3. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
    Title: Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
  4. NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
    Title: NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
  5. Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis, migration and invasion through regulating miR-381-3p/NEK5 axis in nasopharyngeal carcinoma.
    Title: Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis, migration and invasion through regulating miR-381-3p/NEK5 axis in nasopharyngeal carcinoma.
  6. NEK5 interacts with topoisomerase IIbeta and is involved in the DNA damage response induced by etoposide.
    Title: NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide.
  7. the NEK protein kinases emerge as important proteins in thyroid cancer development and may help to identify malignancy and aggressiveness features during diagnosis.
    Title: Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.
  8. Data show that up-regulated NEK5 was significantly associated with breast tumor progression and poor overall prognosis; and that silencing of NEK5 can significantly suppress the proliferation both in vivo and in vitro, inhibiting migration, and invasion. NEK5 can up-regulate Cyclin A2 by direct interaction.
    Title: NEK5 promotes breast cancer cell proliferation through up-regulation of Cyclin A2.
  9. The hNek5 is mitochondrial localization and its role on cell death and cell respiration defects through COX11, MTX2 and BCLAF1.
    Title: Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration.
  10. Nek5 is required for the loss of centrosome linker proteins and enhanced microtubule nucleation that lead to timely centrosome separation and bipolar spindle formation in mitosis
    Title: Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC75495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek5
Names
NIMA (never in mitosis gene a)-related kinase 5
nimA-related protein kinase 5
NP_001352481.1
NP_954983.1
XP_006719871.2
XP_011533368.1
XP_011533370.1
XP_016876045.1
XP_047286243.1
XP_047286244.1
XP_047286245.1
XP_047286246.1
XP_047286247.1
XP_047286248.1
XP_047286249.1
XP_047286250.1
XP_047286251.1
XP_054230467.1
XP_054230468.1
XP_054230469.1
XP_054230470.1
XP_054230471.1
XP_054230472.1
XP_054230473.1
XP_054230474.1
XP_054230475.1
XP_054230476.1
XP_054230477.1
XP_054230478.1
XP_054230479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365552.1 → NP_001352481.1  serine/threonine-protein kinase Nek5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL139082
    Consensus CDS
    CCDS91811.1
    UniProtKB/TrEMBL
    A0A3B3ITQ6, A0A8I5KQI9
    Related
    ENSP00000509632.1, ENST00000684899.1
    Conserved Domains (1) summary
    cd08225
    Location:3 → 259
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  2. NM_199289.3 → NP_954983.1  serine/threonine-protein kinase Nek5 isoform 1

    See identical proteins and their annotated locations for NP_954983.1

    Status: VALIDATED

    Source sequence(s)
    AL139082, BC063885, HY018243
    Consensus CDS
    CCDS31979.1
    UniProtKB/Swiss-Prot
    Q5TAP5, Q6P3R8
    UniProtKB/TrEMBL
    A0A494C168
    Related
    ENSP00000347767.4, ENST00000355568.8
    Conserved Domains (2) summary
    cd08225
    Location:3 → 259
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:4 → 259
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    52033611..52129073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430292.1 → XP_047286248.1  serine/threonine-protein kinase Nek5 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KQI9

  2. XM_047430293.1 → XP_047286249.1  serine/threonine-protein kinase Nek5 isoform X7

  3. XM_047430291.1 → XP_047286247.1  serine/threonine-protein kinase Nek5 isoform X5

  4. XM_047430290.1 → XP_047286246.1  serine/threonine-protein kinase Nek5 isoform X4

  5. XM_047430288.1 → XP_047286244.1  serine/threonine-protein kinase Nek5 isoform X2

  6. XM_047430287.1 → XP_047286243.1  serine/threonine-protein kinase Nek5 isoform X1

  7. XM_047430289.1 → XP_047286245.1  serine/threonine-protein kinase Nek5 isoform X3

  8. XM_047430294.1 → XP_047286250.1  serine/threonine-protein kinase Nek5 isoform X8

  9. XM_047430295.1 → XP_047286251.1  serine/threonine-protein kinase Nek5 isoform X11

  10. XM_011535066.3 → XP_011533368.1  serine/threonine-protein kinase Nek5 isoform X10

    UniProtKB/TrEMBL
    A0A494C168
    Conserved Domains (2) summary
    cd08225
    Location:75 → 331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76 → 331
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  11. XM_017020556.2 → XP_016876045.1  serine/threonine-protein kinase Nek5 isoform X9

    UniProtKB/TrEMBL
    A0A494C168

  12. XM_006719808.5 → XP_006719871.2  serine/threonine-protein kinase Nek5 isoform X12

    Conserved Domains (2) summary
    cd08225
    Location:75 → 331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76 → 331
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  13. XM_011535068.3 → XP_011533370.1  serine/threonine-protein kinase Nek5 isoform X13

    Conserved Domains (2) summary
    cd08225
    Location:75 → 331
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:76 → 331
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. XR_941575.3 RNA Sequence

  2. XR_941574.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    51248427..51343906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374497.1 → XP_054230472.1  serine/threonine-protein kinase Nek5 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KQI9

  2. XM_054374498.1 → XP_054230473.1  serine/threonine-protein kinase Nek5 isoform X7

  3. XM_054374496.1 → XP_054230471.1  serine/threonine-protein kinase Nek5 isoform X5

  4. XM_054374495.1 → XP_054230470.1  serine/threonine-protein kinase Nek5 isoform X4

  5. XM_054374493.1 → XP_054230468.1  serine/threonine-protein kinase Nek5 isoform X2

  6. XM_054374492.1 → XP_054230467.1  serine/threonine-protein kinase Nek5 isoform X1

  7. XM_054374494.1 → XP_054230469.1  serine/threonine-protein kinase Nek5 isoform X3

  8. XM_054374499.1 → XP_054230474.1  serine/threonine-protein kinase Nek5 isoform X8

  9. XM_054374502.1 → XP_054230477.1  serine/threonine-protein kinase Nek5 isoform X11

  10. XM_054374500.1 → XP_054230475.1  serine/threonine-protein kinase Nek5 isoform X9

  11. XM_054374501.1 → XP_054230476.1  serine/threonine-protein kinase Nek5 isoform X10

  12. XM_054374503.1 → XP_054230478.1  serine/threonine-protein kinase Nek5 isoform X12

  13. XM_054374504.1 → XP_054230479.1  serine/threonine-protein kinase Nek5 isoform X13

RNA

  1. XR_008488760.1 RNA Sequence

  2. XR_008488761.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3R8.1 GenPept UniProtKB/Swiss-Prot:Q6P3R8

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