U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ID4 inhibitor of DNA binding 4 [ Homo sapiens (human) ]

Gene ID: 3400, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ID4provided by HGNC
Official Full Name
inhibitor of DNA binding 4provided by HGNC
Primary source
HGNC:HGNC:5363
See related
Ensembl:ENSG00000172201 MIM:600581; AllianceGenome:HGNC:5363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDB4; bHLHb27
Summary
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]
Expression
Biased expression in thyroid (RPKM 167.8), brain (RPKM 37.5) and 12 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (19837370..19842197)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (19709014..19713841)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (19837601..19842428)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:19730720-19731919 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:19734675-19735175 Neighboring gene lncRNA bladder and prostate cancer suppressor, hnRNPK interacting Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:19749583-19750782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:19764761-19765373 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:19765374-19765985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16976 Neighboring gene uncharacterized LOC105374963 Neighboring gene NANOG hESC enhancer GRCh37_chr6:19811543-19812108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:19940204-19940832 Neighboring gene VISTA enhancer hs1175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:20028521-20029021 Neighboring gene ribosomal protein L29 pseudogene 17 Neighboring gene uncharacterized LOC105374965

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ID4 predicts poor prognosis and promotes BDNF-mediated oncogenesis of colorectal cancer. Ha CT, et al. Carcinogenesis, 2021 Jul 16. PMID 33993270
  2. Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer. Baker LA, et al. Breast Cancer Res, 2020 Jun 11. PMID 32527287, Free PMC Article
  3. Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene? Nasif D, et al. Clin Epigenetics, 2018 Aug 23. PMID 30139383, Free PMC Article
  4. Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages. Donzelli S, et al. Breast Cancer Res, 2018 Jun 19. PMID 29921315, Free PMC Article
  5. Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies. Zhou JD, et al. J Cell Mol Med, 2017 Aug. PMID 28452111, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
    Title: ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
  2. Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
    Title: Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
  3. Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer.
    Title: Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer.
  4. CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors.
    Title: CDC42 as an epigenetic regulator of ID4 in triple-negative breast tumors.
  5. miR-9-5p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting ID4.
    Title: miR-9-5p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting ID4.
  6. ID4 predicts poor prognosis and promotes BDNF-mediated oncogenesis of colorectal cancer.
    Title: ID4 predicts poor prognosis and promotes BDNF-mediated oncogenesis of colorectal cancer.
  7. UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes.
    Title: UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes.
  8. Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages.
    Title: Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages.
  9. Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer.
    Title: Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer.
  10. miR-335/ID4 dysregulation facilitated leukemogenesis through the activation of the PI3K/Akt signaling pathway.
    Title: MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (83)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study link novel loci to endometriosis.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in prostate gland epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in prostate gland stromal morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in seminal vesicle morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA-binding protein inhibitor ID-4
Names
class B basic helix-loop-helix protein 27
inhibitor of DNA binding 4, HLH protein
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
inhibitor of differentiation 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001546.4 → NP_001537.1  DNA-binding protein inhibitor ID-4

    See identical proteins and their annotated locations for NP_001537.1

    Status: REVIEWED

    Source sequence(s)
    AI692586, AL022726, BC014941, DB461864
    Consensus CDS
    CCDS4544.1
    UniProtKB/Swiss-Prot
    P47928, Q13005
    Related
    ENSP00000367972.3, ENST00000378700.8
    Conserved Domains (1) summary
    cd19694
    Location:62 → 117
    bHLH_dnHLH_ID4; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    19837370..19842197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    19709014..19713841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47928.1 GenPept UniProtKB/Swiss-Prot:P47928

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous