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HRH2 histamine receptor H2 [ Homo sapiens (human) ]

Gene ID: 3274, updated on 11-Apr-2024

Summary

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Official Symbol
HRH2provided by HGNC
Official Full Name
histamine receptor H2provided by HGNC
Primary source
HGNC:HGNC:5183
See related
Ensembl:ENSG00000113749 MIM:142703; AllianceGenome:HGNC:5183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2R; HH2R
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175658071..175710756)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176201850..176254534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175085074..175137759)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16644 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr5:174905945-174906540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174911541-174912114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:174943953-174945152 Neighboring gene sideroflexin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174960972-174961510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174967065-174967566 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174974284-174975206 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174988020-174988638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175023214-175023754 Neighboring gene Sharpr-MPRA regulatory region 8396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175044235-175044430 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175065813-175066006 Neighboring gene RN7SK pseudogene 148 Neighboring gene NANOG hESC enhancer GRCh37_chr5:175076996-175077520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175090952-175091530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175113560-175114280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175114281-175115000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175115001-175115720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175115721-175116440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175117667-175118168 Neighboring gene uncharacterized LOC105377743 Neighboring gene Sharpr-MPRA regulatory region 12912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175125521-175126418 Neighboring gene RNA, U6 small nuclear 226, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175156005-175156730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175200075-175200861 Neighboring gene uncharacterized LOC124901140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175247615-175248115 Neighboring gene uncharacterized LOC105377744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16646 Neighboring gene complexin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells. Pal S, et al. Biol Open, 2022 Jul 15. PMID 35776777, Free PMC Article
  2. Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Leary PJ, et al. Am J Cardiol, 2018 Jan 15. PMID 29191567, Free PMC Article
  3. Histamine H2 receptor stimulation upregulates T(H)2 chemokine CCL17 production in human M2a macrophages. Mommert S, et al. J Allergy Clin Immunol, 2018 Feb. PMID 28728999
  4. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population. Cai WK, et al. ScientificWorldJournal, 2015. PMID 25922853, Free PMC Article
  5. Histamine type 2 receptor expression on peripheral blood regulatory lymphocytes in patients with allergic rhinitis treated with specific immunotherapy. Ciebiada M, et al. Am J Rhinol Allergy, 2014 May-Jun. PMID 24980224

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment.
    Title: Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G(s) complex in nanodisc environment.
  2. The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4[+] T cells.
    Title: The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells.
  3. Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells.
    Title: Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells.
  4. Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
    Title: Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
  5. Histamine H2 receptor stimulation upregulates TH2 chemokine CCL17 production in human M2a macrophages.
    Title: Histamine H2 receptor stimulation upregulates T(H)2 chemokine CCL17 production in human M2a macrophages.
  6. The presence of a minor allele at rs2241562 was associated with increased HF incidence in Chinese participants. Differences in myocardial HRH2 transcript abundance were seen in participants with dilated cardiomyopathy who responded to beta blockade compared to those who did not.
    Title: Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial).
  7. Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells
    Title: Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors.
  8. The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study
    Title: Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
  9. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the beta2-adrenergic receptor
    Title: High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor.
  10. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population
    Title: Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gastric acid secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histamine H2 receptor
Names
gastric receptor 1
gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131055.2 → NP_001124527.1  histamine H2 receptor isoform 1

    See identical proteins and their annotated locations for NP_001124527.1

    Status: REVIEWED

    Source sequence(s)
    BC054510, CF147823
    Consensus CDS
    CCDS47344.1
    UniProtKB/Swiss-Prot
    P25021
    Related
    ENSP00000366506.2, ENST00000377291.2
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001367711.1 → NP_001354640.1  histamine H2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Consensus CDS
    CCDS93828.1
    UniProtKB/TrEMBL
    A0A1B0GTK7
    Related
    ENSP00000489742.1, ENST00000636584.2
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001393460.1 → NP_001380389.1  histamine H2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Consensus CDS
    CCDS93828.1
    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001393461.1 → NP_001380390.1  histamine H2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Consensus CDS
    CCDS93828.1
    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_160284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Related
    ENST00000624694.2

  2. NR_171689.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010219

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    175658071..175710756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534549.4 → XP_011532851.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011532851.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19 → 299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006714865.4 → XP_006714928.1  histamine H2 receptor isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:35 → 288
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    176201850..176254534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352491.1 → XP_054208466.1  histamine H2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A1B0GTK7

  2. XM_054352492.1 → XP_054208467.1  histamine H2 receptor isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022304.2: Suppressed sequence

    Description
    NM_022304.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25021.1 GenPept UniProtKB/Swiss-Prot:P25021

Gene LinkOut

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