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ADGRE4P adhesion G protein-coupled receptor E4, pseudogene [ Homo sapiens (human) ]

Gene ID: 326342, updated on 10-Oct-2023

Summary

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Official Symbol
ADGRE4Pprovided by HGNC
Official Full Name
adhesion G protein-coupled receptor E4, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:19240
See related
MIM:612305; AllianceGenome:HGNC:19240
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMR4; FIRE; EMR4P; PGR16; GPR127
Summary
This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]
Expression
Broad expression in spleen (RPKM 5.6), appendix (RPKM 2.1) and 14 other tissues See more
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Genomic context

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Location:
19p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6950758..6997851, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6940057..6988111, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6950769..6997862, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6772949-6773449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13864 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6782716-6782888 Neighboring gene MPRA-validated peak3307 silencer Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6801723-6802243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13866 Neighboring gene Sharpr-MPRA regulatory region 13171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13867 Neighboring gene MPRA-validated peak3310 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13868 Neighboring gene uncharacterized LOC105372256 Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9970 Neighboring gene uncharacterized LOC112268245 Neighboring gene MARK2 pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. Caminschi I, et al. DNA Seq, 2006 Feb. PMID 16753812
  2. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. Hamann J, et al. Eur J Immunol, 2003 May. PMID 12731063
  3. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Fredriksson R, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565841
  4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel member of the EGF-TM7 family was identified in mice, termed FIRE (F4/80 like receptor).
    Title: Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE.
  2. EMR4 accounts for a genetic difference between humans and primates related to immunity.
    Title: Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • EGF-TM7 receptor EMR4
  • G protein-coupled receptor 127
  • egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024075.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC025278

  2. NR_174976.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC025278

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6950758..6997851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6940057..6988111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080498.2: Suppressed sequence

    Description
    NM_001080498.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

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