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TAAR6 trace amine associated receptor 6 [ Homo sapiens (human) ]

Gene ID: 319100, updated on 5-Mar-2024

Summary

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Official Symbol
TAAR6provided by HGNC
Official Full Name
trace amine associated receptor 6provided by HGNC
Primary source
HGNC:HGNC:20978
See related
Ensembl:ENSG00000146383 MIM:608923; AllianceGenome:HGNC:20978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TA4; TAR4; TAR6; TRAR4; taR-4; taR-6
Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]
Orthologs
mouse all
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Genomic context

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See TAAR6 in Genome Data Viewer
Location:
6q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132570322..132571359)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133765283..133766320)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132891461..132892498)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 8 Neighboring gene trace amine associated receptor 7, pseudogene Neighboring gene trace amine associated receptor 5 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. Chang HS, et al. Pharmacogenet Genomics, 2015 Jul. PMID 25919112
  2. TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Pae CU, et al. Psychiatry Res, 2010 Nov 30. PMID 20493543
  3. Influence of TAAR6 polymorphisms on response to aripiprazole. Serretti A, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2009 Aug 1. PMID 19345712
  4. The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. Vladimirov VI, et al. Schizophr Res, 2009 Feb. PMID 18973992, Free PMC Article
  5. No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. Ludewick HP, et al. Psychiatr Genet, 2008 Aug. PMID 18628684

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
    Title: Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
  2. Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
    Title: Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
  3. Among the 15 SNPs and seven haplotypes of TAAR6, rs7772821 (T>G) on the 3'-UTR showed the strongest correlation with inhaled corticosteroid-induced %DeltaFEV1 in asthmatics.
    Title: Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.
  4. The results of this study suggested a possible role of TAAR6 in antidepressant response and suicide behavior in patients with depressive disorder
    Title: TAAR6 variations possibly associated with antidepressant response and suicidal behavior.
  5. an epistastic effect between a set of TAAR6 and HSP-70 gene variations has a role in major mood disorders
    Title: Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.
  6. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD.
    Title: TAAR 6 and HSP-70 variations associated with bipolar disorder.
  7. Analysis of epistasis between a set of variations located in the TAAR6 and HSP-70 genes found weak associations with the risk of psychosis and response to antipsychotic treatment
    Title: Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: TAAR6 variations possibly associated with antidepressant response and suicidal behavior.
  9. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample.
    Title: The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
  10. We reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set of TAAR6 variations and clinical presentation and outcome in a sample of 240 SZ Korean patients.
    Title: TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables trace-amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
trace amine-associated receptor 6
Names
trace amine receptor 4
trace amine receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016544.1 RefSeqGene

    Range
    5001..6038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175067.1 → NP_778237.1  trace amine-associated receptor 6

    See identical proteins and their annotated locations for NP_778237.1

    Status: REVIEWED

    Source sequence(s)
    AY183470
    Consensus CDS
    CCDS5155.1
    UniProtKB/Swiss-Prot
    Q5VUQ4, Q96RI8
    Related
    ENSP00000275198.1, ENST00000275198.1
    Conserved Domains (2) summary
    pfam00001
    Location:49 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:43 → 271
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132570322..132571359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133765283..133766320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RI8.1 GenPept UniProtKB/Swiss-Prot:Q96RI8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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