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HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 [ Homo sapiens (human) ]

Gene ID: 3189, updated on 7-Apr-2024

Summary

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Official Symbol
HNRNPH3provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein H3provided by HGNC
Primary source
HGNC:HGNC:5043
See related
Ensembl:ENSG00000096746 MIM:602324; AllianceGenome:HGNC:5043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2H9; HNRPH3
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 44.3), ovary (RPKM 43.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (68331693..68343196)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (69200902..69212407)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70091450..70102953)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16219 Neighboring gene long intergenic non-protein coding RNA 2640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70010536-70011036 Neighboring gene keratin 19 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16457 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16478 Neighboring gene MPRA-validated peak989 silencer Neighboring gene MPRA-validated peak990 silencer Neighboring gene phenazine biosynthesis like protein domain containing Neighboring gene MPRA-validated peak991 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3460 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70091533-70092347 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70092348-70093161 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16571 Neighboring gene MPRA-validated peak992 silencer Neighboring gene RUN and FYVE domain containing 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16583 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16593 Neighboring gene MPRA-validated peak994 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70166191-70166692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70166693-70167192 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16635 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16643 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16656 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_16661/16662 and experimental_16666/16667 Neighboring gene ribosomal protein L26 pseudogene 29 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16674 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16683 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16686/16687 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16694 Neighboring gene RNA, 5S ribosomal pseudogene 319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of Hnrph3 as an autoantigen for acute anterior uveitis. Kim Y, et al. Clin Immunol, 2011 Jan. PMID 20943442, Free PMC Article
  2. A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand. Yagüe J, et al. Protein Sci, 2000 Nov. PMID 11152131, Free PMC Article
  3. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. Honoré B. Biochim Biophys Acta, 2000 Jun 21. PMID 10858537
  4. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. Mahé D, et al. J Biol Chem, 1997 Jan 17. PMID 8999868
  5. Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion. Liu M, et al. Front Immunol, 2021. PMID 34484222, Free PMC Article

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion.
    Title: Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion.
  2. A novel heterogeneous nuclear ribonucleoprotein H3-ALK receptor tyrosine kinase rearrangement was found in one de novo salivary duct carcinoma
    Title: The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.
  3. Using ORF phage display, heterogeneous nuclear ribonucleoprotein H3 (Hnrph3) was, among other candidates, identified as an autoantigen for acute anterior uveitis.
    Title: Identification of Hnrph3 as an autoantigen for acute anterior uveitis.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPH3 is increased by RRE PubMed
Tat tat Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat HIV-1 Tat is identified to have a physical interaction with heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H3
Names
heterogeneous nuclear ribonucleoprotein 2H9
hnRNP 2H9
hnRNP H3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322434.2 → NP_001309363.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), along with variants 2H9, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  2. NM_001322436.2 → NP_001309365.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), along with variants 2H9, 3, and 5, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
    UniProtKB/TrEMBL
    Q53F48
    Related
    ENST00000491200.5
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  3. NM_001322437.2 → NP_001309366.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), along with variants 2H9, 3, and 4, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  4. NM_001322438.1 → NP_001309367.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), along with variants 2H9A, 7, 8, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  5. NM_001322439.2 → NP_001309368.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), along with variants 2H9A, 6, 8, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  6. NM_001322440.2 → NP_001309369.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), along with variants 2H9A, 6, 7, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  7. NM_001322441.2 → NP_001309370.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variants 2H9A, 6, 7, and 8, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  8. NM_001322442.2 → NP_001309371.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) and variant 11 both encode the same isoform (c).
    Source sequence(s)
    AC016395
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:189 → 263
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  9. NM_001322443.2 → NP_001309372.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) and variant 10 both encode the same isoform (c).
    Source sequence(s)
    AC016395
    UniProtKB/TrEMBL
    Q53F48
    Conserved Domains (2) summary
    cd12735
    Location:189 → 263
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  10. NM_001322444.2 → NP_001309373.1  heterogeneous nuclear ribonucleoprotein H3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC016395
    UniProtKB/TrEMBL
    B4DHY1
    Conserved Domains (1) summary
    cl17169
    Location:87 → 161
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_001322445.1 → NP_001309374.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), along with variants 14, 15, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. NM_001322446.2 → NP_001309375.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), along with variants 13, 15, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. NM_001322447.2 → NP_001309376.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), along with variants 13, 14, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. NM_001322448.2 → NP_001309377.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), along with variants 13, 14, 15, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  15. NM_001322449.2 → NP_001309378.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), along with variants 13, 14, 15, and 16, encodes isoform e.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  16. NM_001322450.2 → NP_001309379.1  heterogeneous nuclear ribonucleoprotein H3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:58 → 132
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. NM_001322451.2 → NP_001309380.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), along with variants 20 and 21, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. NM_001322452.2 → NP_001309381.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), along with variants 19 and 21, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. NM_001322453.2 → NP_001309382.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), along with variants 19 and 20, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  20. NM_012207.3 → NP_036339.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    See identical proteins and their annotated locations for NP_036339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2H9) encodes the longest isoform (a). Variants 2H9, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AF132362, AK223441, AW189387, DA486117
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
    UniProtKB/TrEMBL
    Q53F48
    Related
    ENSP00000265866.7, ENST00000265866.12
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  21. NM_021644.4 → NP_067676.2  heterogeneous nuclear ribonucleoprotein H3 isoform b

    See identical proteins and their annotated locations for NP_067676.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2H9A) uses an alternative donor splice site at one of the internal coding exons compared to transcript variant 2H9. However, it maintains the reading frame and encodes an isoform (b) that is missing a 15 aa segment compared to isoform a. Variants 2H9A, 6, 7, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AW189387, BC039824, DA486117
    Consensus CDS
    CCDS7279.1
    UniProtKB/TrEMBL
    Q53F48
    Related
    ENSP00000346726.5, ENST00000354695.5
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    68331693..68343196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    69200902..69212407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31942.2 GenPept UniProtKB/Swiss-Prot:P31942

Gene LinkOut

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