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HNRNPD heterogeneous nuclear ribonucleoprotein D [ Homo sapiens (human) ]

Gene ID: 3184, updated on 16-Apr-2024

Summary

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Official Symbol
HNRNPDprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Dprovided by HGNC
Primary source
HGNC:HGNC:5036
See related
Ensembl:ENSG00000138668 MIM:601324; AllianceGenome:HGNC:5036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P37; AUF1; AUF1A; HNRPD; hnRNPD0
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 80.4), bone marrow (RPKM 72.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4q21.22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82352498..82373991, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (85681761..85703272, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83273651..83295144, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15527 Neighboring gene bridging integrator 2 pseudogene 1 Neighboring gene MPRA-validated peak5068 silencer Neighboring gene vesicle associated membrane protein 9, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83287023-83287694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83301399-83301972 Neighboring gene HNRNPD divergent transcript Neighboring gene IGBP1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. Li ML, et al. J Biol Chem, 2022 Oct. PMID 36041631, Free PMC Article
  2. Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1. Zhang Z, et al. J Genet Genomics, 2023 Mar. PMID 35940521
  3. Effects of ribosomal associated protein hnRNP D in gemcitabine-resistant pancreatic cancer. Wang C, et al. Biochem Biophys Res Commun, 2021 Nov 19. PMID 34624736
  4. The overexpression of AUF1 in colorectal cancer predicts a poor prognosis and promotes cancer progression by activating ERK and AKT pathways. Tian XY, et al. Cancer Med, 2020 Nov. PMID 33016643, Free PMC Article
  5. Alternatively spliced isoforms of AUF1 regulate a miRNA-mRNA interaction differentially through their YGG motif. Sänger L, et al. RNA Biol, 2021 Jun. PMID 32924750, Free PMC Article

See all (355) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis.
    Title: CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis.
  2. AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity.
    Title: AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity.
  3. AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis.
    Title: AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis.
  4. Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation.
    Title: Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation.
  5. AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.
    Title: AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.
  6. Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.
    Title: Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.
  7. Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.
    Title: Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.
  8. PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.
    Title: PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.
  9. The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
    Title: The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
  10. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane.
    Title: The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane.
Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP D decreases HIV-1 Env synthesis PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Depletion of hnRNP D reduces the accumulation of HIV-1 unspliced and singly spliced RNAs and decreases synthesis of HIV-1 Gag in the cytoplasm PubMed
gag Overexpression of hnRNP D isoform d p37 and isoform c p40 suppress HIV-1 Gag synthesis, while overexpression of isoform a p45 and isoform b p42 increase HIV-1 Gag synthesis PubMed
gag hnRNP D protein undergoes relocalization to the cytoplasm upon HIV-1 infection and is associated with HIV-1 Gag protein PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein D (HNRNPD), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPD is increased by RRE PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of heterogeneous nuclear ribonucleoprotein D (HNRNPD) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables minor groove of adenine-thymine-rich DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in CRD-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to putrescine IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hepatocyte dedifferentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomerase RNA reverse transcriptase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of telomere capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of telomere maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to rapamycin IEA
Inferred from Electronic Annotation
more info
  
involved_in response to sodium phosphate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
part_of mCRD-mediated mRNA stability complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein D0
Names
ARE-binding protein AUFI, type A
AU-rich RNA-binding factor 1
AU-rich element RNA binding protein 1, 37kDa
hnRNP D0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029103.1 RefSeqGene

    Range
    5006..26499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003810.2 → NP_001003810.1  heterogeneous nuclear ribonucleoprotein D0 isoform d

    See identical proteins and their annotated locations for NP_001003810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame segments, compared to variant 1. The resulting isoform (d), also known as p37, is shorter than isoform a.
    Source sequence(s)
    AC124016, AF039575, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
    Consensus CDS
    CCDS93554.1
    UniProtKB/TrEMBL
    B4DTC3
    Related
    ENSP00000422615.2, ENST00000503822.2
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  2. NM_002138.4 → NP_002129.2  heterogeneous nuclear ribonucleoprotein D0 isoform c

    See identical proteins and their annotated locations for NP_002129.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (c), also known as p40, is shorter than isoform a.
    Source sequence(s)
    AC124016, AF039575, BC023977, BF693760, BM825808
    Consensus CDS
    CCDS3590.1
    UniProtKB/TrEMBL
    B4DTC3
    Related
    ENSP00000313327.6, ENST00000353341.8
    Conserved Domains (3) summary
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:99 → 172
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  3. NM_031369.3 → NP_112737.1  heterogeneous nuclear ribonucleoprotein D0 isoform b

    See identical proteins and their annotated locations for NP_112737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (b), also known as p42, is shorter than isoform a.
    Source sequence(s)
    AC124016, AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
    Consensus CDS
    CCDS3591.1
    UniProtKB/TrEMBL
    B4DTC3
    Related
    ENSP00000305860.6, ENST00000352301.8
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  4. NM_031370.3 → NP_112738.1  heterogeneous nuclear ribonucleoprotein D0 isoform a

    See identical proteins and their annotated locations for NP_112738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a), also known as p45.
    Source sequence(s)
    AC124016, AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BM825808, BM832779
    Consensus CDS
    CCDS3592.1
    UniProtKB/Swiss-Prot
    A8K9J2, P07029, Q01858, Q14100, Q14101, Q14102, Q14103, Q4W5A1, Q9UCE8, Q9UCE9
    UniProtKB/TrEMBL
    B4DTC3
    Related
    ENSP00000313199.7, ENST00000313899.12
    Conserved Domains (3) summary
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:99 → 172
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    82352498..82373991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    85681761..85703272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14103.1 GenPept UniProtKB/Swiss-Prot:Q14103

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