H1-0 H1.0 linker histone [Homo sapiens (human)] - Gene

Summary

Official Symbol: H1-0provided by HGNC
Official Full Name: H1.0 linker histoneprovided by HGNC
Primary source: HGNC:HGNC:4714
See related: Ensembl:ENSG00000189060 MIM:142708; AllianceGenome:HGNC:4714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H10; H1.0; H1F0; H1FV
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37805229..37807432)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (38266869..38269059)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (38201236..38203439)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Title: Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.
Title: Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.
Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.
Title: Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.
Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.
Title: Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.
The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.
Title: The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Title: Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Histone H1 acetylation at lysine 85 (H1K85) mutation leads to genomic instability and decreased cell survival upon DNA damage.
Title: Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.
Measure the binding affinity for the prothymosin-alpha (ProTalpha)-H1.0 complex using isothermal titration calorimetry and report a KD value of (4.6 +/- 0.5) x 10(-7) M. In addition, we show that ProTalpha facilitates the formation of the H1.0-nucleosome complex in vitro.
Title: Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα.
H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X.
Title: Regulation of Cellular Dynamics and Chromosomal Binding Site Preference of Linker Histones H1.0 and H1.X.
this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth.
Title: The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29683 (e-PCR)
- UniSTS:72511

STS-W90034 (e-PCR)
- UniSTS:46658

RH27824 (e-PCR)
- UniSTS:85317

G31469 (e-PCR)
- UniSTS:32448

RH17516 (e-PCR)
- UniSTS:69594

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables minor groove of adenine-thymine-rich DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H1.0

Names: H1 histone family member 0; H1.0, H1(0), H1-0; histone H1'; histone H1(0)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.