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SLC2A8 solute carrier family 2 member 8 [ Homo sapiens (human) ]

Gene ID: 29988, updated on 3-Apr-2024

Summary

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Official Symbol
SLC2A8provided by HGNC
Official Full Name
solute carrier family 2 member 8provided by HGNC
Primary source
HGNC:HGNC:13812
See related
Ensembl:ENSG00000136856 MIM:605245; AllianceGenome:HGNC:13812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUTX1
Summary
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Expression
Broad expression in testis (RPKM 16.3), adrenal (RPKM 7.3) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
9q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127397169..127407898)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139603648..139615379)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130159448..130170177)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene DENR pseudogene 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:130094714-130095913 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:130098321-130099520 Neighboring gene Sharpr-MPRA regulatory region 1510 Neighboring gene uncharacterized LOC124902275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130146967-130147700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130168662-130169228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180180-130180827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180828-130181474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130185748-130186690 Neighboring gene zinc finger protein 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29040 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains. Mashima M, et al. Neurosci Lett, 2017 Jan 1. PMID 27818355
  2. GLUT8, the enigmatic intracellular hexose transporter. Schmidt S, et al. Am J Physiol Endocrinol Metab, 2009 Apr. PMID 19176349
  3. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. Janzen C, et al. PLoS One, 2018. PMID 29590129, Free PMC Article
  4. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Mayer AL, et al. Sci Rep, 2016 Dec 6. PMID 27922102, Free PMC Article
  5. Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells. Murakami R, et al. Histochem Cell Biol, 2016 Aug. PMID 27160096

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction
    Title: Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.
  2. these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction.
    Title: SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.
  3. glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle
    Title: Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains.
  4. The findings support the hypothesis of the transport of intravascularGLUT8 through the epithelial cells of the choroid plexus and the ependymal cells.
    Title: Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.
  5. GLUT8 is thus essential for hepatocyte fructose transport and fructose-induced macrosteatosis.
    Title: Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
  6. SLC2A8 is upregulated in fast progressing Alzheimer's disease patients, compared to slow progressors.
    Title: Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.
  7. Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer.
    Title: Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
  9. The expression pattern of GLUT8 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
    Title: Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
  10. The recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and that endocytosis might be the main site at which GLUT8 is likely to be regulated.
    Title: Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables dehydroascorbic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fructose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in dehydroascorbic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in lysosomal membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 8
Names
glucose transporter type 8
glucose transporter type X1
solute carrier family 2 (facilitated glucose transporter), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271711.2 → NP_001258640.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 2

    See identical proteins and their annotated locations for NP_001258640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform 2 is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF289587, AI818661, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS65138.1
    UniProtKB/TrEMBL
    Q5VVV9
    Related
    ENSP00000362458.3, ENST00000373360.7
    Conserved Domains (1) summary
    cd06174
    Location:38 → 331
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_001271712.2 → NP_001258641.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 3

    See identical proteins and their annotated locations for NP_001258641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI818661, BC019043, BX395379, HY025817
    Consensus CDS
    CCDS75903.1
    UniProtKB/TrEMBL
    A0A087WT42, Q5VVV4
    Related
    ENSP00000477568.1, ENST00000610552.4
    Conserved Domains (1) summary
    cd06174
    Location:90 → 296
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_014580.5 → NP_055395.2  solute carrier family 2, facilitated glucose transporter member 8 isoform 1

    See identical proteins and their annotated locations for NP_055395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform 1.
    Source sequence(s)
    AF289587, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS6870.1
    UniProtKB/Swiss-Prot
    Q8WUZ9, Q9NSC4, Q9NY64
    Related
    ENSP00000362469.3, ENST00000373371.8
    Conserved Domains (2) summary
    cd06174
    Location:38 → 459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36 → 472
    xylE; D-xylose transporter XylE; Provisional

RNA

  1. NR_073416.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF289587, AL445222, BC019043, BM044230, HY025817

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127397169..127407898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423283.1 → XP_047279239.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

  2. XM_047423287.1 → XP_047279243.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

  3. XM_047423285.1 → XP_047279241.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

  4. XM_011518602.3 → XP_011516904.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

    Conserved Domains (2) summary
    cd06174
    Location:38 → 433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36 → 446
    xylE; D-xylose transporter XylE; Provisional

  5. XM_017014653.2 → XP_016870142.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X14

    UniProtKB/TrEMBL
    Q5VVV3, Q8WZ05
    Conserved Domains (1) summary
    pfam00083
    Location:1 → 187
    Sugar_tr; Sugar (and other) transporter

  6. XM_047423293.1 → XP_047279249.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X12

  7. XM_047423286.1 → XP_047279242.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

  8. XM_006717084.4 → XP_006717147.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:38 → 423
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  9. XM_024447526.2 → XP_024303294.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X13

    UniProtKB/TrEMBL
    Q5VVV4
    Related
    ENSP00000391213.1, ENST00000430147.1
    Conserved Domains (1) summary
    cl26863
    Location:1 → 261
    Sugar_tr; Sugar (and other) transporter

  10. XM_047423294.1 → XP_047279250.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X15

  11. XM_047423288.1 → XP_047279244.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X7

  12. XM_047423289.1 → XP_047279245.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X9

  13. XM_047423290.1 → XP_047279246.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  14. XM_047423292.1 → XP_047279248.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  15. XM_011518603.4 → XP_011516905.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X8

    UniProtKB/TrEMBL
    Q5VVV4
    Conserved Domains (1) summary
    cd06174
    Location:118 → 324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  16. XM_011518604.4 → XP_011516906.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X10

    Conserved Domains (1) summary
    cd06174
    Location:8 → 298
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139603648..139615379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362834.1 → XP_054218809.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

  2. XM_054362837.1 → XP_054218812.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

  3. XM_054362835.1 → XP_054218810.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

  4. XM_054362838.1 → XP_054218813.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

  5. XM_054362848.1 → XP_054218823.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X14

    UniProtKB/TrEMBL
    Q8WZ05

  6. XM_054362846.1 → XP_054218821.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X12

  7. XM_054362836.1 → XP_054218811.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

  8. XM_054362839.1 → XP_054218814.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X6

  9. XM_054362847.1 → XP_054218822.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X13

  10. XM_054362849.1 → XP_054218824.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X15

  11. XM_054362840.1 → XP_054218815.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X7

  12. XM_054362842.1 → XP_054218817.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X9

  13. XM_054362844.1 → XP_054218819.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  14. XM_054362845.1 → XP_054218820.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  15. XM_054362841.1 → XP_054218816.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X8

  16. XM_054362843.1 → XP_054218818.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X10

RNA

  1. XR_008487994.1 RNA Sequence

  2. XR_008487995.1 RNA Sequence

  3. XR_008487997.1 RNA Sequence

  4. XR_008487998.1 RNA Sequence

  5. XR_008487999.1 RNA Sequence

  6. XR_008488000.1 RNA Sequence

  7. XR_008487996.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NY64.3 GenPept UniProtKB/Swiss-Prot:Q9NY64

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