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PURG purine rich element binding protein G [ Homo sapiens (human) ]

Gene ID: 29942, updated on 5-Mar-2024

Summary

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Official Symbol
PURGprovided by HGNC
Official Full Name
purine rich element binding protein Gprovided by HGNC
Primary source
HGNC:HGNC:17930
See related
Ensembl:ENSG00000172733 MIM:618041; AllianceGenome:HGNC:17930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PURGA; PURGB; PURG-A; PURG-B
Summary
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
Expression
Biased expression in brain (RPKM 1.4), testis (RPKM 1.1) and 12 other tissues See more
Orthologs
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Genomic context

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See PURG in Genome Data Viewer
Location:
8p12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30995802..31033356, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (31276938..31314481, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30853318..30890872, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene uncharacterized LOC105379357 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:30763109-30763340 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30776396-30776897 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene MPRA-validated peak6979 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30891079-30891600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914375-30914876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914877-30915376 Neighboring gene WRN RecQ like helicase Neighboring gene SUMO2 pseudogene 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:31029565-31030764 Neighboring gene uncharacterized LOC105379358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Liu H, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034829, Free PMC Article
  2. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. Xie L, et al. PLoS Genet, 2012. PMID 23284306, Free PMC Article
  3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
  4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation
    Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of purine-rich element binding protein G (PURG) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding HDA PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
purine-rich element-binding protein gamma
Names
Pur-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015508.3 → NP_001015508.1  purine-rich element-binding protein gamma isoform B

    See identical proteins and their annotated locations for NP_001015508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
    Source sequence(s)
    AC008066, AW170055, AY077841
    Consensus CDS
    CCDS34878.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Related
    ENSP00000345168.2, ENST00000339382.3
    Conserved Domains (1) summary
    pfam04845
    Location:57 → 290
    PurA; PurA ssDNA and RNA-binding protein

  2. NM_001323311.2 → NP_001310240.1  purine-rich element-binding protein gamma isoform A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A and C encode the same isoform (A).
    Source sequence(s)
    AC084736, AF195513, DR003356
    Consensus CDS
    CCDS6081.1
    UniProtKB/Swiss-Prot
    Q8TE64, Q9UJV8
    Related
    ENSP00000466881.2, ENST00000523392.2
    Conserved Domains (1) summary
    pfam04845
    Location:57 → 321
    PurA; PurA ssDNA and RNA-binding protein

  3. NM_001323312.2 → NP_001310241.1  purine-rich element-binding protein gamma isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' and 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
    Source sequence(s)
    AC008066, AC084736, AW170055, AY077841, DR003356
    Consensus CDS
    CCDS34878.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Conserved Domains (1) summary
    pfam04845
    Location:57 → 290
    PurA; PurA ssDNA and RNA-binding protein

  4. NM_013357.2 → NP_037489.1  purine-rich element-binding protein gamma isoform A

    See identical proteins and their annotated locations for NP_037489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A). Variants A and C encode the same isoform (A).
    Source sequence(s)
    AF195513
    Consensus CDS
    CCDS6081.1
    UniProtKB/Swiss-Prot
    Q8TE64, Q9UJV8
    Related
    ENSP00000418721.1, ENST00000475541.2
    Conserved Domains (1) summary
    pfam04845
    Location:57 → 321
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    30995802..31033356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    31276938..31314481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJV8.1 GenPept UniProtKB/Swiss-Prot:Q9UJV8

Gene LinkOut

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