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GTF2A2 general transcription factor IIA subunit 2 [ Homo sapiens (human) ]

Gene ID: 2958, updated on 5-Mar-2024

Summary

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Official Symbol
GTF2A2provided by HGNC
Official Full Name
general transcription factor IIA subunit 2provided by HGNC
Primary source
HGNC:HGNC:4647
See related
Ensembl:ENSG00000140307 MIM:600519; AllianceGenome:HGNC:4647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma
Summary
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues See more
Orthologs
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Genomic context

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See GTF2A2 in Genome Data Viewer
Location:
15q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59638062..59657515, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57439769..57459225, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59930261..59949714, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 117 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59908775-59909010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9499 Neighboring gene BCL2 interacting protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59981225-59981873 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit. Mitsiou DJ, et al. Mol Cell, 2000 Sep. PMID 11030333
  2. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Kuhlman TC, et al. Mol Cell Biol, 1999 Mar. PMID 10022900, Free PMC Article
  3. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. DeJong J, et al. Genes Dev, 1993 Nov. PMID 8224848
  4. A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner. Wang J, et al. J Biol Chem, 2017 Jul 14. PMID 28539359, Free PMC Article
  5. p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction. Xing J, et al. Mol Cell Biol, 2001 Jun. PMID 11340159, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300)
    Title: A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
  2. transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
    Title: Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II general transcription initiation factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription initiation factor IIA subunit 2
Names
TFIIA gamma subunit
TFIIA p12 subunit
general transcription factor IIA 2
general transcription factor IIA, 2, 12kDa
transcription initiation factor IIA gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320929.2 → NP_001307858.1  transcription initiation factor IIA subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC092755, BX099306, HY002503, HY036972
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    A8MYQ7, P52657, Q6FGB5
    UniProtKB/TrEMBL
    B2R506
    Related
    ENSP00000379373.1, ENST00000396061.5
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

  2. NM_001320930.2 → NP_001307859.1  transcription initiation factor IIA subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC092755, BX099306, CB156109
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    A8MYQ7, P52657, Q6FGB5
    UniProtKB/TrEMBL
    B2R506
    Related
    ENSP00000379375.1, ENST00000396063.5
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

  3. NM_004492.3 → NP_004483.1  transcription initiation factor IIA subunit 2

    See identical proteins and their annotated locations for NP_004483.1

    Status: VALIDATED

    Source sequence(s)
    AK312015, BC000287, CV572751, DB531003
    Consensus CDS
    CCDS10173.1
    UniProtKB/Swiss-Prot
    A8MYQ7, P52657, Q6FGB5
    UniProtKB/TrEMBL
    B2R506
    Related
    ENSP00000379372.2, ENST00000396060.7
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    59638062..59657515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    57439769..57459225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52657.1 GenPept UniProtKB/Swiss-Prot:P52657

Gene LinkOut

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