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GSPT1 G1 to S phase transition 1 [ Homo sapiens (human) ]

Gene ID: 2935, updated on 7-Apr-2024

Summary

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Official Symbol
GSPT1provided by HGNC
Official Full Name
G1 to S phase transition 1provided by HGNC
Primary source
HGNC:HGNC:4621
See related
Ensembl:ENSG00000103342 MIM:139259; AllianceGenome:HGNC:4621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST1; ETF3A; eRF3a; 551G9.2
Summary
Enables translation release factor activity. Involved in regulation of translational termination. Acts upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 16.3), colon (RPKM 15.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11868128..11916654, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11904164..11952697, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11961985..12010511, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11946068-11946601 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12009257-12010194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12011253-12011753 Neighboring gene nuclear pore complex interacting protein family member B2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10462 Neighboring gene TNF receptor superfamily member 17 Neighboring gene ubiquitin like 5 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GSPT1 Functions as a Tumor Promoter in Human Liver Cancer. Xi YQ, et al. Curr Med Sci, 2023 Feb. PMID 36459303
  2. Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway. Long X, et al. Aging (Albany NY), 2021 Apr 4. PMID 33819920, Free PMC Article
  3. Role of GSPT1 and GSPT2 polymorphisms in different outcomes upon Hepatitis B virus infection and prognosis to lamivudine therapy. Liu W, et al. Biosci Rep, 2019 Mar 29. PMID 30867251, Free PMC Article
  4. Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility. Jerbi S, et al. RNA Biol, 2016. PMID 26818177, Free PMC Article
  5. Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay. Osawa M, et al. RNA, 2012 Nov. PMID 23019593, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein.
    Title: MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein.
  2. GSPT1 Functions as a Tumor Promoter in Human Liver Cancer.
    Title: GSPT1 Functions as a Tumor Promoter in Human Liver Cancer.
  3. Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma.
    Title: Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma.
  4. Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3beta/CyclinD1 pathway.
    Title: Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway.
  5. miR-27b-3p suppresses gastric cancer cell proliferation, invasion, and migration via negative expression regulation of GSPT1.
    Title: Downregulation of microRNA-27b-3p via aberrant DNA methylation contributes to malignant behavior of gastric cancer cells by targeting GSPT1.
  6. Data show that G1 to S phase transition 1 protein (GSPT1)-rs33635C was a predictor for lamivudine (LAM) therapy.
    Title: Role of GSPT1 and GSPT2 polymorphisms in different outcomes upon Hepatitis B virus infection and prognosis to lamivudine therapy.
  7. miR-144 was found to be down-regulated in gastric cancer tissues while GSPT1 expression level was markedly increased; GSPT1 was a direct target of miR-144.
    Title: The role of miR-144/GSPT1 axis in gastric cancer.
  8. PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination.
    Title: PABP enhances release factor recruitment and stop codon recognition during translation termination.
  9. Data found that the N-terminal glycine repeat of eRF3a influences eRF3a-PABP interaction and that eRF3a 12-GGC allele has a decreased binding affinity for PABP.
    Title: Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility.
  10. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
    Title: Identification of four new susceptibility loci for testicular germ cell tumour.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38048, FLJ39067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation release factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of translation release factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Names
G1 to S phase transition protein 1 homolog
eukaryotic peptide chain release factor subunit 3a
eukaryotic release factor 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130006.2 → NP_001123478.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC007216
    Consensus CDS
    CCDS45413.1
    UniProtKB/TrEMBL
    B4DQM6
    Related
    ENSP00000408399.2, ENST00000439887.6
    Conserved Domains (2) summary
    COG5256
    Location:209 → 633
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:65 → 81
    PAM2; Ataxin-2 C-terminal region

  2. NM_001130007.2 → NP_001123479.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 3

    See identical proteins and their annotated locations for NP_001123479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminal, compared to isoform 1.
    Source sequence(s)
    AC007216, AK315267, BM666324, BT006722
    Consensus CDS
    CCDS45414.1
    UniProtKB/Swiss-Prot
    J3KQG6, P15170, Q96GF2
    UniProtKB/TrEMBL
    A8K2W7, B2RCT6
    Related
    ENSP00000399539.2, ENST00000420576.6
    Conserved Domains (1) summary
    COG5256
    Location:72 → 496
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

  3. NM_002094.4 → NP_002085.3  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007216
    Consensus CDS
    CCDS45412.1
    Related
    ENSP00000398131.2, ENST00000434724.7
    Conserved Domains (2) summary
    COG5256
    Location:210 → 634
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:64 → 81
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11868128..11916654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434035.1 → XP_047289991.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X3

  2. XM_047434034.1 → XP_047289990.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X2

  3. XM_047434033.1 → XP_047289989.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11904164..11952697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380181.1 → XP_054236156.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X3

  2. XM_054380180.1 → XP_054236155.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X2

  3. XM_054380179.1 → XP_054236154.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15170.1 GenPept UniProtKB/Swiss-Prot:P15170

Gene LinkOut

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