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ATAD2 ATPase family AAA domain containing 2 [ Homo sapiens (human) ]

Gene ID: 29028, updated on 11-Apr-2024

Summary

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Official Symbol
ATAD2provided by HGNC
Official Full Name
ATPase family AAA domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30123
See related
Ensembl:ENSG00000156802 MIM:611941; AllianceGenome:HGNC:30123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANCCA; CT137; PRO2000
Summary
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues See more
Orthologs
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Genomic context

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See ATAD2 in Genome Data Viewer
Location:
8q24.13
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123319850..123416350, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124450947..124547457, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124332090..124408687, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124285783-124286150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27871 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1385 Neighboring gene RNA, U6 small nuclear 875, pseudogene Neighboring gene microRNA 548aa-1 Neighboring gene microRNA 548d-1 Neighboring gene deoxyuridine triphosphatase pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124405259-124405759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19498 Neighboring gene Sharpr-MPRA regulatory region 2006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124422560-124423060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124423061-124423561 Neighboring gene MPRA-validated peak7156 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19499 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124429186-124429780 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene uncharacterized LOC124902105 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491440-124491940 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:124491941-124492441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:124518725-124519269 Neighboring gene F-box protein 32 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:124539974-124541173 Neighboring gene MPRA-validated peak7157 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration. Wang C, et al. Dis Markers, 2022. PMID 36479043, Free PMC Article
  2. Tumor-Promoting ATAD2 and Its Preclinical Challenges. Liu H, et al. Biomolecules, 2022 Jul 28. PMID 36008934, Free PMC Article
  3. Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. Evans CM, et al. Int J Mol Sci, 2021 Aug 24. PMID 34502039, Free PMC Article
  4. Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain. Nayak A, et al. J Biomol Struct Dyn, 2022 Aug. PMID 33438526
  5. Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma. Meng X, et al. Biomed Res Int, 2020. PMID 32462022, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
    Title: Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
  2. MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
    Title: MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
  3. ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
    Title: ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
  4. Tumor-Promoting ATAD2 and Its Preclinical Challenges.
    Title: Tumor-Promoting ATAD2 and Its Preclinical Challenges.
  5. Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
    Title: Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
  6. Effect of chronic intermittent hypoxia-induced HIF-1alpha/ATAD2 expression on lung cancer stemness.
    Title: Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.
  7. ATAD2 controls chromatin-bound HIRA turnover.
    Title: ATAD2 controls chromatin-bound HIRA turnover.
  8. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
    Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
  9. ATAD2 interacts with C/EBPbeta to promote esophageal squamous cell carcinoma metastasis via TGF-beta1/Smad3 signaling.
    Title: ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
  10. Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
    Title: Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5254, MGC29843, MGC131938, MGC142216, DKFZp667N1320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATPase family AAA domain-containing protein 2
Names
AAA nuclear coregulator cancer-associated protein
NP_054828.2
XP_011515296.1
XP_011515297.1
XP_011515298.1
XP_047277678.1
XP_047277679.1
XP_047277680.1
XP_047277681.1
XP_054216337.1
XP_054216338.1
XP_054216339.1
XP_054216340.1
XP_054216341.1
XP_054216342.1
XP_054216343.1
XP_054216344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014109.4 → NP_054828.2  ATPase family AAA domain-containing protein 2

    See identical proteins and their annotated locations for NP_054828.2

    Status: REVIEWED

    Source sequence(s)
    BC113656, BP314109, CA441499, CB159561
    Consensus CDS
    CCDS6343.1
    UniProtKB/Swiss-Prot
    Q14CR1, Q658P2, Q68CQ0, Q6PJV6, Q6PL18, Q8N890, Q9UHS5
    Related
    ENSP00000287394.5, ENST00000287394.10
    Conserved Domains (4) summary
    cd05528
    Location:987 → 1097
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:459 → 600
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:915 → 1153
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:464 → 598
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    123319850..123416350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421723.1 → XP_047277679.1  ATPase family AAA domain-containing protein 2 isoform X2

  2. XM_047421722.1 → XP_047277678.1  ATPase family AAA domain-containing protein 2 isoform X2

  3. XM_011516994.4 → XP_011515296.1  ATPase family AAA domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:987 → 1097
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:459 → 600
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:915 → 1160
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:464 → 598
    AAA; ATPase family associated with various cellular activities (AAA)

  4. XM_011516996.4 → XP_011515298.1  ATPase family AAA domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0B4J211
    Related
    ENSP00000429213.1, ENST00000521903.5
    Conserved Domains (2) summary
    cd05528
    Location:446 → 556
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    cl21455
    Location:17 → 57
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_047421724.1 → XP_047277680.1  ATPase family AAA domain-containing protein 2 isoform X5

  6. XM_011516995.4 → XP_011515297.1  ATPase family AAA domain-containing protein 2 isoform X3

    Related
    ENST00000521496.5
    Conserved Domains (2) summary
    smart00382
    Location:459 → 600
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:464 → 598
    AAA; ATPase family associated with various cellular activities (AAA)

  7. XM_047421725.1 → XP_047277681.1  ATPase family AAA domain-containing protein 2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    124450947..124547457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360364.1 → XP_054216339.1  ATPase family AAA domain-containing protein 2 isoform X2

  2. XM_054360363.1 → XP_054216338.1  ATPase family AAA domain-containing protein 2 isoform X2

  3. XM_054360362.1 → XP_054216337.1  ATPase family AAA domain-containing protein 2 isoform X1

  4. XM_054360365.1 → XP_054216340.1  ATPase family AAA domain-containing protein 2 isoform X2

  5. XM_054360367.1 → XP_054216342.1  ATPase family AAA domain-containing protein 2 isoform X4

  6. XM_054360368.1 → XP_054216343.1  ATPase family AAA domain-containing protein 2 isoform X5

  7. XM_054360366.1 → XP_054216341.1  ATPase family AAA domain-containing protein 2 isoform X3

  8. XM_054360369.1 → XP_054216344.1  ATPase family AAA domain-containing protein 2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PL18.1 GenPept UniProtKB/Swiss-Prot:Q6PL18

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