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P2RY8 P2Y receptor family member 8 [ Homo sapiens (human) ]

Gene ID: 286530, updated on 11-Apr-2024

Summary

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Official Symbol
P2RY8provided by HGNC
Official Full Name
P2Y receptor family member 8provided by HGNC
Primary source
HGNC:HGNC:15524
See related
Ensembl:ENSG00000182162 Ensembl:ENSG00000292333 MIM:300525; AllianceGenome:HGNC:15524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y8
Summary
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 13.9), spleen (RPKM 8.9) and 14 other tissues See more
Orthologs
all
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Genomic context

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Location:
X;Y
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1462581..1537185, complement)
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1462581..1537185, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1304499..1339638, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1325951..1401516, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1581474..1656078, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1531474..1606078, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance. He Y, et al. J Exp Med, 2022 Jan 3. PMID 34889940, Free PMC Article
  2. S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Lu E, et al. Nature, 2019 Mar. PMID 30842656, Free PMC Article
  3. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. Fujiwara S, et al. Leuk Lymphoma, 2007 May. PMID 17487742
  4. [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement]. Zheng YZ, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Apr. PMID 33812392
  5. Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia. Dou H, et al. Genes Chromosomes Cancer, 2017 Feb. PMID 27637012

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
    Title: P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
  2. [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
    Title: [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
  3. S-Geranylgeranyl-L-glutathione(GGG) is identified as an intercellular signalling molecule that is involved in organizing and controlling germinal-centre responses; as the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, GGG might have organizing and growth-regulatory roles in multiple human tissues
    Title: S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.
  4. P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia.
    Title: Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia.
  5. P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.
    Title: The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
  6. P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.
    Title: Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL.
  7. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
    Title: Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
  8. Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement.
    Title: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.
  9. SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma
    Title: Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.
  10. P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia
    Title: Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC50878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 8
Names
G-protein coupled purinergic receptor P2Y8
purinergic receptor P2Y, G-protein coupled, 8
purinergic receptor P2Y8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013252.1 RefSeqGene

    Range
    4960..79564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001424186.1 → NP_001411115.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  2. NM_001424187.1 → NP_001411116.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  3. NM_001424188.1 → NP_001411117.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  4. NM_001424189.1 → NP_001411118.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  5. NM_001424190.1 → NP_001411119.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  6. NM_001424191.1 → NP_001411120.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  7. NM_001424192.1 → NP_001411121.1  P2Y purinoceptor 8

    Status: REVIEWED

    Source sequence(s)
    AL683870
    UniProtKB/Swiss-Prot
    Q86VZ1

  8. NM_178129.5 → NP_835230.1  P2Y purinoceptor 8

    See identical proteins and their annotated locations for NP_835230.1

    Status: REVIEWED

    Source sequence(s)
    AI476104, AK092956, AL683870, AL833184, BC043610, BE245848
    Consensus CDS
    CCDS14115.1
    UniProtKB/Swiss-Prot
    Q86VZ1
    Related
    ENSP00000370697.4, ENSP00000518611.1, ENST00000381297.10, ENST00000711216.1
    Conserved Domains (1) summary
    cd15368
    Location:24 → 304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1462581..1537185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274429.4 → XP_005274486.1  P2Y purinoceptor 8 isoform X1

    See identical proteins and their annotated locations for XP_005274486.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24 → 304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1462581..1537185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274778.4 → XP_005274835.1  P2Y purinoceptor 8 isoform X1

    See identical proteins and their annotated locations for XP_005274835.1

    UniProtKB/Swiss-Prot
    Q86VZ1
    Conserved Domains (1) summary
    cd15368
    Location:24 → 304
    7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    1304499..1339638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1325951..1401516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328280.1 → XP_054184255.1  P2Y purinoceptor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q86VZ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VZ1.1 GenPept UniProtKB/Swiss-Prot:Q86VZ1

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