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C3orf33 chromosome 3 open reading frame 33 [ Homo sapiens (human) ]

Gene ID: 285315, updated on 5-Mar-2024

Summary

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Official Symbol
C3orf33provided by HGNC
Official Full Name
chromosome 3 open reading frame 33provided by HGNC
Primary source
HGNC:HGNC:26434
See related
Ensembl:ENSG00000174928 MIM:619654; AllianceGenome:HGNC:26434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC3-33
Summary
Involved in negative regulation of ERK1 and ERK2 cascade and regulation of DNA-binding transcription factor activity. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.9), adrenal (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q25.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (155762617..155806278, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (158536490..158580161, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155480406..155524067, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipase C eta 1 Neighboring gene ribosomal protein L6 pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155462097-155462718 Neighboring gene ribosomal protein L7a pseudogene 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:155507600-155507774 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:155508647-155509846 Neighboring gene MPRA-validated peak4874 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14833 Neighboring gene solute carrier family 33 member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20722 Neighboring gene uncharacterized LOC105374174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Analysis of AC3-33 gene expression in multiple organ cancer and adjacent normal tissue by RNA in situ hybridization. Hu F, et al. Oncol Lett, 2015 Jun. PMID 26137149, Free PMC Article
  2. Prokaryotic expression and characterization of human AC3-33 protein. Zhang X, et al. Front Biosci (Elite Ed), 2010 Jun 1. PMID 20515784
  3. [Molecular cloning and preliminary function study of a novel human gene AC3-33 related to suppress AP-1 activity]. Liu P, et al. Yi Chuan, 2008 May. PMID 18487146
  4. AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway. Hao D, et al. Mol Biol Rep, 2011 Feb. PMID 20680465
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AC3-33 is a novel member of the secretory family and inhibits Elk1 transcriptional activity via ERK1/2 MAP
    Title: AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway.
  2. The preliminary results showed that AC3-33 is an important novel gene related to supress AP-1 activity.
    Title: [Molecular cloning and preliminary function study of a novel human gene AC3-33 related to suppress AP-1 activity].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein C3orf33
Names
AP-1 activity suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308229.2 → NP_001295158.1  protein C3orf33 isoform 1

    See identical proteins and their annotated locations for NP_001295158.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC104472, AF115515, DA275323
    Consensus CDS
    CCDS77843.1
    UniProtKB/Swiss-Prot
    A8K1H5, Q6P1S2, Q86YE6, Q8IXA7, Q96NB5
    Related
    ENSP00000342512.2, ENST00000340171.7

  2. NM_173657.3 → NP_775928.1  protein C3orf33 isoform 2

    See identical proteins and their annotated locations for NP_775928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104472, AK055701, DA275323
    Consensus CDS
    CCDS54659.1
    UniProtKB/Swiss-Prot
    Q6P1S2
    Related
    ENSP00000445446.1, ENST00000534941.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    155762617..155806278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512710.3 → XP_011511012.1  protein C3orf33 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    158536490..158580161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346300.1 → XP_054202275.1  protein C3orf33 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1S2.2 GenPept UniProtKB/Swiss-Prot:Q6P1S2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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