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EPHA10 EPH receptor A10 [ Homo sapiens (human) ]

Gene ID: 284656, updated on 11-Apr-2024

Summary

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Official Symbol
EPHA10provided by HGNC
Official Full Name
EPH receptor A10provided by HGNC
Primary source
HGNC:HGNC:19987
See related
Ensembl:ENSG00000183317 MIM:611123; AllianceGenome:HGNC:19987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNA88
Summary
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 7.0), colon (RPKM 2.9) and 7 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37713880..37765120, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37578599..37629649, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38181648..38230792, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38157950-38158460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38158461-38158969 Neighboring gene cell division cycle associated 8 Neighboring gene MPRA-validated peak183 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191191-38191692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191693-38192192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192280-38192780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192781-38193281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38201025-38201524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 677 Neighboring gene uncharacterized LOC105378650 Neighboring gene actinin alpha 4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans. Huang S, et al. Hum Mol Genet, 2023 Feb 19. PMID 36048850
  2. EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma. Zhao W, et al. Int Immunopharmacol, 2022 Sep. PMID 35839564
  3. Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex. Li Y, et al. Oncotarget, 2017 May 2. PMID 28427223, Free PMC Article
  4. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. Nagano K, et al. J Control Release, 2014 Sep 10. PMID 24946238
  5. Eph receptor A10 has a potential as a target for a prostate cancer therapy. Nagano K, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24924629

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
    Title: A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
  2. EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
    Title: EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
  3. Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
    Title: Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
  4. Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
    Title: Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
  5. Cataloguing the dead: breathing new life into pseudokinase research.
    Title: Cataloguing the dead: breathing new life into pseudokinase research.
  6. we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage.
    Title: Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex.
  7. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.
    Title: EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.
  8. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers
    Title: Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers.
  9. Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here.
    Title: Eph receptor A10 has a potential as a target for a prostate cancer therapy.
  10. EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression.
    Title: Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hearing loss, autosomal dominant 88
MedGen: C5830355 OMIM: 620283 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16103, FLJ33655, MGC43817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 10
Names
EphA10s protein
NP_001092909.1
NP_775912.2
XP_016856569.1
XP_016856570.1
XP_047274347.1
XP_047274359.1
XP_054192110.1
XP_054192111.1
XP_054192112.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099439.2 → NP_001092909.1  ephrin type-A receptor 10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001092909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
    Source sequence(s)
    AC104336, AJ872185, BC039363, BC041360
    Consensus CDS
    CCDS41305.1
    UniProtKB/Swiss-Prot
    A4FU89, J3KPB5, Q5JZY3, Q6NW42
    UniProtKB/TrEMBL
    J3KQG3
    Related
    ENSP00000362139.4, ENST00000373048.9
    Conserved Domains (8) summary
    cd05064
    Location:639 → 904
    PTKc_EphR_A10; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
    smart00454
    Location:932 → 997
    SAM; Sterile alpha motif
    cd00063
    Location:451 → 531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339 → 431
    fn3; Fibronectin type III domain
    pfam07714
    Location:645 → 900
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:573 → 640
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl15755
    Location:929 → 998
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_173641.3 → NP_775912.2  ephrin type-A receptor 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_775912.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains only the first three exons and some of the third intron compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AJ781169, AK090974, BC067734
    Consensus CDS
    CCDS425.1
    UniProtKB/TrEMBL
    Q8N289
    Related
    ENSP00000316395.6, ENST00000319637.6
    Conserved Domains (1) summary
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    37713880..37765120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001080.1 → XP_016856569.1  ephrin type-A receptor 10 isoform X1

    UniProtKB/TrEMBL
    Q6ZNH1
    Related
    ENST00000446149.6

  2. XM_047418403.1 → XP_047274359.1  ephrin type-A receptor 10 isoform X4

    Related
    ENSP00000431389.1, ENST00000534097.5

  3. XM_017001081.2 → XP_016856570.1  ephrin type-A receptor 10 isoform X3

  4. XM_047418391.1 → XP_047274347.1  ephrin type-A receptor 10 isoform X2

RNA

  1. XR_946610.2 RNA Sequence

  2. XR_001737124.2 RNA Sequence

  3. XR_946613.3 RNA Sequence

  4. XR_001737123.2 RNA Sequence

  5. XR_001737125.3 RNA Sequence

  6. XR_001737127.1 RNA Sequence

  7. XR_001737126.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    37578599..37629649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336135.1 → XP_054192110.1  ephrin type-A receptor 10 isoform X1

  2. XM_054336137.1 → XP_054192112.1  ephrin type-A receptor 10 isoform X4

  3. XM_054336136.1 → XP_054192111.1  ephrin type-A receptor 10 isoform X3

RNA

  1. XR_008486004.1 RNA Sequence

  2. XR_008486003.1 RNA Sequence

  3. XR_008486001.1 RNA Sequence

  4. XR_008486002.1 RNA Sequence

  5. XR_008486005.1 RNA Sequence

  6. XR_008486007.1 RNA Sequence

  7. XR_008486006.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004338.2: Suppressed sequence

    Description
    NM_001004338.2: This RefSeq was permanently suppressed because the encoded protein is partial, and it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JZY3.2 GenPept UniProtKB/Swiss-Prot:Q5JZY3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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