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SLC9C2 solute carrier family 9 member C2 (putative) [ Homo sapiens (human) ]

Gene ID: 284525, updated on 3-Apr-2024

Summary

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Official Symbol
SLC9C2provided by HGNC
Official Full Name
solute carrier family 9 member C2 (putative)provided by HGNC
Primary source
HGNC:HGNC:28664
See related
Ensembl:ENSG00000162753 MIM:620338; AllianceGenome:HGNC:28664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHE11; SLC9A11
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 4.6) See more
Orthologs
mouse all
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Genomic context

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Location:
1q25.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173500460..173603072, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (172858618..172961223, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173469599..173572211, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 4 Neighboring gene uncharacterized LOC100506023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2111 Neighboring gene Sharpr-MPRA regulatory region 8886 Neighboring gene PRDX6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2112 Neighboring gene Sharpr-MPRA regulatory region 679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173429231-173429730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173445479-173446015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2113 Neighboring gene uncharacterized LOC124904456 Neighboring gene MPRA-validated peak459 silencer Neighboring gene Sharpr-MPRA regulatory region 4744 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173473949-173475148 Neighboring gene peroxiredoxin 6 Neighboring gene uncharacterized LOC105371619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173610829-173612028 Neighboring gene ankyrin repeat domain 45 Neighboring gene small nucleolar RNA U13 Neighboring gene testis expressed 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Traditional and emerging roles for the SLC9 Na+/H+ exchangers. Fuster DG, et al. Pflugers Arch, 2014 Jan. PMID 24337822
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • MGC43026

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 11
Names
NHE-11
Na(+)/H(+) exchanger 11
solute carrier family 9, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178527.4 → NP_848622.2  sodium/hydrogen exchanger 11

    See identical proteins and their annotated locations for NP_848622.2

    Status: VALIDATED

    Source sequence(s)
    AK128104, AL139142, BC042592, DB071569
    Consensus CDS
    CCDS1308.1
    UniProtKB/Swiss-Prot
    Q5TAH2, Q86UF3
    UniProtKB/TrEMBL
    B3KXW8
    Related
    ENSP00000356687.3, ENST00000367714.4
    Conserved Domains (3) summary
    cd00038
    Location:873 → 980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638 → 731
    Ion_trans; Ion transport protein
    cl01133
    Location:98 → 380
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173500460..173603072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418170.1 → XP_047274126.1  sodium/hydrogen exchanger 11 isoform X6

  2. XM_017001074.2 → XP_016856563.1  sodium/hydrogen exchanger 11 isoform X5

    UniProtKB/TrEMBL
    B3KXW8

  3. XM_047418169.1 → XP_047274125.1  sodium/hydrogen exchanger 11 isoform X6

  4. XM_017001073.2 → XP_016856562.1  sodium/hydrogen exchanger 11 isoform X5

    UniProtKB/TrEMBL
    B3KXW8

  5. XM_017001071.2 → XP_016856560.1  sodium/hydrogen exchanger 11 isoform X3

    UniProtKB/TrEMBL
    B3KXW8

  6. XM_017001070.2 → XP_016856559.1  sodium/hydrogen exchanger 11 isoform X2

    UniProtKB/TrEMBL
    B3KXW8

  7. XM_017001066.2 → XP_016856555.1  sodium/hydrogen exchanger 11 isoform X1

    UniProtKB/TrEMBL
    B3KXW8
    Conserved Domains (3) summary
    cd00038
    Location:873 → 980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638 → 731
    Ion_trans; Ion transport protein
    cl01133
    Location:98 → 380
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  8. XM_017001069.3 → XP_016856558.1  sodium/hydrogen exchanger 11 isoform X2

    UniProtKB/TrEMBL
    B3KXW8

  9. XM_017001065.3 → XP_016856554.1  sodium/hydrogen exchanger 11 isoform X1

    UniProtKB/TrEMBL
    B3KXW8
    Conserved Domains (3) summary
    cd00038
    Location:873 → 980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638 → 731
    Ion_trans; Ion transport protein
    cl01133
    Location:98 → 380
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  10. XM_017001072.3 → XP_016856561.1  sodium/hydrogen exchanger 11 isoform X4

    UniProtKB/TrEMBL
    B3KXW8

  11. XM_017001068.3 → XP_016856557.1  sodium/hydrogen exchanger 11 isoform X2

    UniProtKB/TrEMBL
    B3KXW8

  12. XM_011509426.3 → XP_011507728.1  sodium/hydrogen exchanger 11 isoform X1

    UniProtKB/TrEMBL
    B3KXW8
    Conserved Domains (3) summary
    cd00038
    Location:873 → 980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638 → 731
    Ion_trans; Ion transport protein
    cl01133
    Location:98 → 380
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  13. XM_017001075.2 → XP_016856564.1  sodium/hydrogen exchanger 11 isoform X7

    Related
    ENST00000466087.1

  14. XM_017001076.2 → XP_016856565.1  sodium/hydrogen exchanger 11 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    172858618..172961223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336120.1 → XP_054192095.1  sodium/hydrogen exchanger 11 isoform X6

  2. XM_054336118.1 → XP_054192093.1  sodium/hydrogen exchanger 11 isoform X5

  3. XM_054336119.1 → XP_054192094.1  sodium/hydrogen exchanger 11 isoform X6

  4. XM_054336117.1 → XP_054192092.1  sodium/hydrogen exchanger 11 isoform X5

  5. XM_054336115.1 → XP_054192090.1  sodium/hydrogen exchanger 11 isoform X3

  6. XM_054336113.1 → XP_054192088.1  sodium/hydrogen exchanger 11 isoform X2

  7. XM_054336110.1 → XP_054192085.1  sodium/hydrogen exchanger 11 isoform X1

  8. XM_054336114.1 → XP_054192089.1  sodium/hydrogen exchanger 11 isoform X2

  9. XM_054336111.1 → XP_054192086.1  sodium/hydrogen exchanger 11 isoform X1

  10. XM_054336116.1 → XP_054192091.1  sodium/hydrogen exchanger 11 isoform X4

  11. XM_054336112.1 → XP_054192087.1  sodium/hydrogen exchanger 11 isoform X2

  12. XM_054336109.1 → XP_054192084.1  sodium/hydrogen exchanger 11 isoform X1

  13. XM_054336121.1 → XP_054192096.1  sodium/hydrogen exchanger 11 isoform X7

  14. XM_054336122.1 → XP_054192097.1  sodium/hydrogen exchanger 11 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TAH2.1 GenPept UniProtKB/Swiss-Prot:Q5TAH2

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