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CXCL17 C-X-C motif chemokine ligand 17 [ Homo sapiens (human) ]

Gene ID: 284340, updated on 31-Mar-2024

Summary

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Official Symbol
CXCL17provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 17provided by HGNC
Primary source
HGNC:HGNC:19232
See related
Ensembl:ENSG00000189377 MIM:611387; AllianceGenome:HGNC:19232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMC; VCC1; Dcip1; VCC-1; UNQ473
Summary
The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in stomach (RPKM 182.1), lung (RPKM 72.2) and 3 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42428278..42442946, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45247666..45262340, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42932430..42947098, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42901001-42901684 Neighboring gene uncharacterized LOC101930071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42901685-42902368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42910752-42911558 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14718 Neighboring gene lipase E, hormone sensitive type Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42969789-42970289 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42975464-42976444 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42977425-42978405 Neighboring gene MPRA-validated peak3491 silencer Neighboring gene RNA, U4 small nuclear 60, pseudogene Neighboring gene AN1-type zinc finger protein 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation. Gowhari Shabgah A, et al. Cell Biol Int, 2022 Oct. PMID 35811438
  2. Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17. Liu W, et al. Cell Oncol (Dordr), 2020 Apr. PMID 31832986
  3. CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1-AMPK pathway in hepatocellular carcinoma. Wang L, et al. Gene, 2019 Mar 30. PMID 30597237
  4. Lymph node CXCL17 messenger RNA: A new prognostic biomarker for colon cancer. Rashad Y, et al. Tumour Biol, 2018 Sep. PMID 30198422
  5. CXCL17 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma. Li L, et al. PLoS One, 2014. PMID 25303284, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
    Title: Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
  2. Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression.
    Title: Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression.
  3. A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation.
    Title: A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation.
  4. THUMPD3-AS1 Is Correlated with Gastric Cancer and Regulates Cell Function through miR-1252-3p and CXCL17.
    Title: THUMPD3-AS1 Is Correlated with Gastric Cancer and Regulates Cell Function through miR-1252-3p and CXCL17.
  5. Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
    Title: Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
  6. CXCL17 Is Dispensable during Hypervirulent Mycobacterium tuberculosis HN878 Infection in Mice.
    Title: CXCL17 Is Dispensable during Hypervirulent Mycobacterium tuberculosis HN878 Infection in Mice.
  7. MiR-325-3p mediate the CXCL17/CXCR8 axis to regulate angiogenesis in hepatocellular carcinoma.
    Title: MiR-325-3p mediate the CXCL17/CXCR8 axis to regulate angiogenesis in hepatocellular carcinoma.
  8. The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
    Title: The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
  9. CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis.
    Title: CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis.
  10. Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17.
    Title: Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
C-X-C motif chemokine 17
Names
6-Cys CXCL17
VEGF co-regulated chemokine 1
VEGF coregulated chemokine 1
chemokine (C-X-C motif) ligand 17
dendritic cell and monocyte chemokine-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198477.3 → NP_940879.1  C-X-C motif chemokine 17 precursor

    See identical proteins and their annotated locations for NP_940879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC011497, AY358433, BU684368
    Consensus CDS
    CCDS12608.1
    UniProtKB/Swiss-Prot
    A8KAC0, Q6UXB2
    Related
    ENSP00000472467.1, ENST00000601181.6
    Conserved Domains (1) summary
    pfam15211
    Location:23 → 111
    CXCL17; VEGF co-regulated chemokine 1

RNA

  1. NR_133910.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011497, AY358433, AY598464, BM978124, BU684368

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42428278..42442946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45247666..45262340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXB2.1 GenPept UniProtKB/Swiss-Prot:Q6UXB2

Gene LinkOut

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