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GPR19 G protein-coupled receptor 19 [ Homo sapiens (human) ]

Gene ID: 2842, updated on 3-Apr-2024

Summary

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Official Symbol
GPR19provided by HGNC
Official Full Name
G protein-coupled receptor 19provided by HGNC
Primary source
HGNC:HGNC:4473
See related
Ensembl:ENSG00000183150 MIM:602927; AllianceGenome:HGNC:4473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
12p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12660890..12717246, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12533185..12589333, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12813824..12849117, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene cAMP responsive element binding protein like 2 Neighboring gene Sharpr-MPRA regulatory region 2795 Neighboring gene uncharacterized LOC124902880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:12796246-12797445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:12829332-12830160 Neighboring gene MPRA-validated peak1575 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12870680-12870868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6029 Neighboring gene uncharacterized LOC105369663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4265 Neighboring gene cyclin dependent kinase inhibitor 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process. Maudsley S, et al. Int J Mol Sci, 2023 May 9. PMID 37239845, Free PMC Article
  2. G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. Rao A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28476646
  3. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. Kastner S, et al. Mol Cancer Res, 2012 Oct. PMID 22912338
  4. Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells. Montpetit A, et al. Hum Genet, 1999 Jul-Aug. PMID 10480372
  5. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. O'Dowd BF, et al. FEBS Lett, 1996 Oct 7. PMID 8830667

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
    Title: Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
  2. GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.
    Title: GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.
  3. GPR19 overexpression drives MDA-MB-231 cells towards an epithelial phenotype. GPR19 upregulates E-cadherin via MAPK/ERK1/2 pathway.
    Title: G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells.
  4. G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
    Title: Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 19
Names
GPR-NGA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006143.3 → NP_006134.2  probable G-protein coupled receptor 19

    Status: VALIDATED

    Source sequence(s)
    AC008115
    Consensus CDS
    CCDS8652.1
    UniProtKB/Swiss-Prot
    Q15760
    UniProtKB/TrEMBL
    B9EK41
    Related
    ENSP00000498976.1, ENST00000651487.1
    Conserved Domains (1) summary
    cd15008
    Location:67 → 341
    7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    12660890..12717246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428742.1 → XP_047284698.1  probable G-protein coupled receptor 19 isoform X2

    UniProtKB/Swiss-Prot
    Q15760

  2. XM_011520623.4 → XP_011518925.1  probable G-protein coupled receptor 19 isoform X1

    See identical proteins and their annotated locations for XP_011518925.1

    UniProtKB/TrEMBL
    B9EK41
    Conserved Domains (2) summary
    pfam00001
    Location:101 → 349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91 → 277
    7tm_4; Olfactory receptor

  3. XM_011520624.3 → XP_011518926.1  probable G-protein coupled receptor 19 isoform X1

    See identical proteins and their annotated locations for XP_011518926.1

    UniProtKB/TrEMBL
    B9EK41
    Conserved Domains (2) summary
    pfam00001
    Location:101 → 349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91 → 277
    7tm_4; Olfactory receptor

  4. XM_047428741.1 → XP_047284697.1  probable G-protein coupled receptor 19 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    12533185..12589333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371850.1 → XP_054227825.1  probable G-protein coupled receptor 19 isoform X1

  2. XM_054371851.1 → XP_054227826.1  probable G-protein coupled receptor 19 isoform X1

  3. XM_054371849.1 → XP_054227824.1  probable G-protein coupled receptor 19 isoform X1

  4. XM_054371852.1 → XP_054227827.1  probable G-protein coupled receptor 19 isoform X2

    UniProtKB/TrEMBL
    Q6IBH2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15760.2 GenPept UniProtKB/Swiss-Prot:Q15760

Gene LinkOut

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