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GPR18 G protein-coupled receptor 18 [ Homo sapiens (human) ]

Gene ID: 2841, updated on 11-Apr-2024

Summary

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Official Symbol
GPR18provided by HGNC
Official Full Name
G protein-coupled receptor 18provided by HGNC
Primary source
HGNC:HGNC:4472
See related
Ensembl:ENSG00000125245 MIM:602042; AllianceGenome:HGNC:4472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRV2
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPR18 in Genome Data Viewer
Location:
13q32.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (99254739..99258379, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98464982..98489443, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99906993..99910633, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99857838-99858338 Neighboring gene RN7SK pseudogene 9 Neighboring gene UBA domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7932 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene uncharacterized LOC124903198 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99914553-99914775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99955752-99956300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99956301-99956847 Neighboring gene G protein-coupled receptor 183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain. Fabisiak A, et al. Neurogastroenterol Motil, 2021 Mar. PMID 33058313
  2. Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity. Sotudeh N, et al. Int J Mol Sci, 2019 May 9. PMID 31075933, Free PMC Article
  3. GPR18 expression on PMNs as biomarker for outcome in patient with sepsis. Zhang L, et al. Life Sci, 2019 Jan 15. PMID 30503722
  4. Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease. Pirault J, et al. Front Pharmacol, 2018. PMID 30487747, Free PMC Article
  5. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Flegel C, et al. Sci Rep, 2016 Aug 30. PMID 27572937, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
    Title: The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
  2. Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
    Title: Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
  3. molecular dynamics simulations of wild-type (WT) GPR18 and the A3.39N mutant in fully hydrated (POPC) phophatidylcholine lipid bilayers, are reported.
    Title: Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.
  4. GPR18 interacts with cannabinoid CB2 but not with CB1 receptors.
    Title: Molecular and functional interaction between GPR18 and cannabinoid CB(2) G-protein-coupled receptors. Relevance in neurodegenerative diseases.
  5. Lipopolysaccharides-Toll-like receptor (TLR)4 signaling mediated the GPR18 expression on polymorphonuclear neutrophils. These results indicate that decreased percentage GPR18-positive polymorphonuclear neutrophils is associated with increased severity and poorer outcome of sepsis.
    Title: GPR18 expression on PMNs as biomarker for outcome in patient with sepsis.
  6. Results indicate that G protein-coupled receptor 18 (GPR18) might be involved in physiological processes of spermatozoa, suggesting GPR18 to be a potential player in sperm physiology.
    Title: Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.
  7. A novel RvD2-GPR18 resolution axis stimulates human and mouse phagocyte functions to control bacterial infections and promote organ protection.
    Title: Identification of resolvin D2 receptor mediating resolution of infections and organ protection.
  8. the results presented herein provide further evidence for GPR18 as a candidate cannabinoid receptor
    Title: Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.
  9. REVIEW: functional properties and in vivo biology
    Title: EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
  10. GPR18, the most abundantly overexpressed orphan G-protein-coupled receptor in all melanoma metastases, is constitutively active and inhibits apoptosis, indicating an important role for GPR18 in tumor cell survival.
    Title: Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta intraepithelial T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in CD8-positive, gamma-delta intraepithelial T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
N-arachidonyl glycine receptor
Names
NAGly receptor
resolvin D2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098200.2 → NP_001091670.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_001091670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA825595, BC008569
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330, Q6GTM3, Q96HI6, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380610.2, ENST00000397470.5
    Conserved Domains (1) summary
    cd15166
    Location:23 → 297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_005292.4 → NP_005283.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_005283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL160155, BC050646, BI770379
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330, Q6GTM3, Q96HI6, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380613.2, ENST00000397473.7
    Conserved Domains (1) summary
    cd15166
    Location:23 → 297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    99254739..99258379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    98464982..98489443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374477.1 → XP_054230452.1  N-arachidonyl glycine receptor isoform X1

    UniProtKB/Swiss-Prot
    Q14330, Q6GTM3, Q96HI6, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1

  2. XM_054374478.1 → XP_054230453.1  N-arachidonyl glycine receptor isoform X1

    UniProtKB/Swiss-Prot
    Q14330, Q6GTM3, Q96HI6, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1

  3. XM_054374479.1 → XP_054230454.1  N-arachidonyl glycine receptor isoform X1

    UniProtKB/Swiss-Prot
    Q14330, Q6GTM3, Q96HI6, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14330.2 GenPept UniProtKB/Swiss-Prot:Q14330

Gene LinkOut

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