U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR15 G protein-coupled receptor 15 [ Homo sapiens (human) ]

Gene ID: 2838, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
GPR15provided by HGNC
Official Full Name
G protein-coupled receptor 15provided by HGNC
Primary source
HGNC:HGNC:4469
See related
Ensembl:ENSG00000154165 MIM:601166; AllianceGenome:HGNC:4469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOB
Summary
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98531978..98534681)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101235662..101238365)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98250822..98253525)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20137 Neighboring gene claudin domain containing 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:98247209-98247752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14557 Neighboring gene RPL38 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20138 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:98274627-98275826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14559 Neighboring gene coproporphyrinogen oxidase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20144 Neighboring gene ribosomal protein L19 pseudogene 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease. Zhao J, et al. Biomolecules, 2022 Dec 18. PMID 36551327, Free PMC Article
  2. GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium. Fernández-Ruiz JC, et al. J Leukoc Biol, 2022 Nov. PMID 36164808
  3. Clonally expanded, GPR15-expressing pathogenic effector T(H)2 cells are associated with eosinophilic esophagitis. Morgan DM, et al. Sci Immunol, 2021 Aug 13. PMID 34389613, Free PMC Article
  4. GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer. Adamczyk A, et al. Cancer Res, 2021 Jun 1. PMID 33727229
  5. Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking. Andersen AM, et al. J Psychosom Res, 2021 Feb. PMID 33310155, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.
    Title: Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.
  2. Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease.
    Title: Elevated Expression and Activation of GPR15 in Immune Cells in Graves' Disease.
  3. GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium.
    Title: GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium.
  4. Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis.
    Title: Clonally expanded, GPR15-expressing pathogenic effector T(H)2 cells are associated with eosinophilic esophagitis.
  5. The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15.
    Title: The aryl hydrocarbon receptor regulates expression of mucosal trafficking receptor GPR15.
  6. GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer.
    Title: GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer.
  7. Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.
    Title: Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.
  8. Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking.
    Title: Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking.
  9. Ahr-Foxp3-RORgammat axis controls gut homing of CD4(+) T cells by regulating GPR15.
    Title: Ahr-Foxp3-RORγt axis controls gut homing of CD4(+) T cells by regulating GPR15.
  10. Cigarette and Cannabis Smoking Effects on GPR15+ Helper T Cell Levels in Peripheral Blood: Relationships with Epigenetic Biomarkers.
    Title: Cigarette and Cannabis Smoking Effects on GPR15+ Helper T Cell Levels in Peripheral Blood: Relationships with Epigenetic Biomarkers.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 ZP6248 T/F virus efficiently uses an alternative coreceptor GPR15 to establish clinical infection, and gp120 G306A, V307A, E314A, K315A, V316A, Y317A, F318A and S322A mutations significantly reduce or abolish the replication capacity in GPR15+ cells PubMed
env HIV gp120-induced calcium signaling, microtubule loss, and physiological changes on HT-29 cells are inhibited by anti-Bob/GPR15 neutralizing antibodies, suggesting that gp120-induced Bob/GRP15 activation is a plausible cause of HIV enteropathy PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC126828, MGC126830

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 15
Names
brother of Bonzo

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005290.4 → NP_005281.1  G-protein coupled receptor 15

    See identical proteins and their annotated locations for NP_005281.1

    Status: REVIEWED

    Source sequence(s)
    AA687817, AC021660, AK313375, BC101779
    Consensus CDS
    CCDS2931.1
    UniProtKB/Swiss-Prot
    P49685, Q3MIL4, Q6ISN6
    UniProtKB/TrEMBL
    B2R8H6, B6V9G9
    Related
    ENSP00000284311.3, ENST00000284311.5
    Conserved Domains (1) summary
    cd15194
    Location:34 → 313
    7tmA_GPR15; G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    98531978..98534681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    101235662..101238365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49685.1 GenPept UniProtKB/Swiss-Prot:P49685

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous