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GNG7 G protein subunit gamma 7 [ Homo sapiens (human) ]

Gene ID: 2788, updated on 5-Mar-2024

Summary

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Official Symbol
GNG7provided by HGNC
Official Full Name
G protein subunit gamma 7provided by HGNC
Primary source
HGNC:HGNC:4410
See related
Ensembl:ENSG00000176533 MIM:604430; AllianceGenome:HGNC:4410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3B
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 18.8), heart (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2511219..2702694, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2487421..2678899, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2511217..2702692, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2494323-2495030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2511755-2512265 Neighboring gene uncharacterized LOC124904789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13697 Neighboring gene RNA, U6 small nuclear 993, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2518390-2519062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13698 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2540747-2541566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2541567-2542386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2543207-2544026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544027-2544846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544847-2545665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2546759-2547703 Neighboring gene elongin C pseudogene 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2556671-2557284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2559714-2560214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567191-2567718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567719-2568246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2575316-2575816 Neighboring gene HNF4 motif-containing MPRA enhancer 50 Neighboring gene Sharpr-MPRA regulatory region 4130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2587299-2588242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2592455-2592956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2603289-2604055 Neighboring gene RNA, 7SL, cytoplasmic 121, pseudogene Neighboring gene H3K4me1 hESC enhancers GRCh37_chr19:2607315-2608169 and GRCh37_chr19:2608170-2609023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9803 Neighboring gene Sharpr-MPRA regulatory region 3019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13710 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:2626979-2628178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2643435-2643934 Neighboring gene microRNA 7850 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2650512-2650687 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene MPRA-validated peak3237 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2678080-2678228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2723575-2724487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2734868-2735368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2735369-2735869 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2739111-2739378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9805 Neighboring gene DIRAS family GTPase 1 Neighboring gene solute carrier family 39 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments. Duan H, et al. Aging (Albany NY), 2023 Feb 24. PMID 36863706, Free PMC Article
  2. G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1. Zheng H, et al. Int J Biol Macromol, 2021 Jul 1. PMID 33864871
  3. G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma. Xu S, et al. J Cell Physiol, 2019 Nov. PMID 30945310, Free PMC Article
  4. Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. Demokan S, et al. Int J Oncol, 2013 Apr. PMID 23403885, Free PMC Article
  5. Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck. Hartmann S, et al. J Appl Genet, 2012 May. PMID 22183866, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
    Title: Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments.
  2. Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
    Title: Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis.
  3. MicroRNA miR-19b-3p mediated G protein gamma subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
    Title: MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling.
  4. GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
    Title: GNG7 and ADCY1 as diagnostic and prognostic biomarkers for pancreatic adenocarcinoma through bioinformatic-based analyses.
  5. G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
    Title: G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.
  6. Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
    Title: Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia.
  7. GNG7 is a tumor suppressor gene in Clear cell renal cell carcinoma progression.
    Title: G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma.
  8. GNG7 is a highly specific promoter methylated gene associated with head and neck cancer.
    Title: Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.
  9. Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation.
    Title: Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.
  10. Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC.
    Title: Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Names
guanine nucleotide binding protein (G protein), gamma 7
heterotrimeric guanine nucleotide-binding protein 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052847.3 → NP_443079.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

    See identical proteins and their annotated locations for NP_443079.1

    Status: VALIDATED

    Source sequence(s)
    AC005512, BC014466, BC053630, DA247608
    Consensus CDS
    CCDS12091.1
    UniProtKB/Swiss-Prot
    B2R496, O60262
    Related
    ENSP00000371594.2, ENST00000382159.8
    Conserved Domains (1) summary
    smart00224
    Location:7 → 68
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2511219..2702694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438629.1 → XP_047294585.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    B2R496, O60262

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2487421..2678899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320580.1 → XP_054176555.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    B2R496, O60262

  2. XM_054320581.1 → XP_054176556.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

    UniProtKB/Swiss-Prot
    B2R496, O60262
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60262.1 GenPept UniProtKB/Swiss-Prot:O60262

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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