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POLL DNA polymerase lambda [ Homo sapiens (human) ]

Gene ID: 27343, updated on 3-Apr-2024

Summary

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Official Symbol
POLLprovided by HGNC
Official Full Name
DNA polymerase lambdaprovided by HGNC
Primary source
HGNC:HGNC:9184
See related
Ensembl:ENSG00000166169 MIM:606343; AllianceGenome:HGNC:9184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BETAN; POLKAPPA
Summary
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in testis (RPKM 14.9), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See POLL in Genome Data Viewer
Location:
10q24.32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101578882..101588270, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102462924..102472307, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103338639..103348027, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U2 small nuclear 59, pseudogene Neighboring gene beta-transducin repeat containing E3 ubiquitin protein ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103201016-103201516 Neighboring gene VISTA enhancer hs326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103320958-103321458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3913 Neighboring gene NANOG hESC enhancer GRCh37_chr10:103356755-103357323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2722 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103367960-103368675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103371133-103371633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103372791-103373324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103373325-103373858 Neighboring gene microRNA 3158-1 Neighboring gene microRNA 3158-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103378239-103379151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103379197-103379698 Neighboring gene deleted in primary ciliary dyskinesia homolog (mouse) Neighboring gene RNA, U6 small nuclear 1165, pseudogene Neighboring gene F-box and WD repeat domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis. van Loon B, et al. Chem Res Toxicol, 2017 Nov 20. PMID 28841305
  2. Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein. Nemec AA, et al. Mol Cancer Res, 2016 Nov. PMID 27621267, Free PMC Article
  3. A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG. Burak MJ, et al. EMBO J, 2016 Sep 15. PMID 27481934, Free PMC Article
  4. Unlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase λ is responsible for a significant part of Fapy·dG-induced G → T mutations in human cells. Pande P, et al. Biochemistry, 2015 Mar 17. PMID 25741586, Free PMC Article
  5. Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λ. Vyas R, et al. Proc Natl Acad Sci U S A, 2014 Jul 29. PMID 25015085, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sustained pigmentation causes DNA damage and invokes translesion polymerase Polkappa for repair in melanocytes.
    Title: Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.
  2. A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres.
    Title: A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
  3. PAXX, XLF and XRCC4 synergise in the efficient DNA double-strand breaks recruitment, substrate recognition and stimulation of Pol lambda enzymatic activity during nonhomologous end joining DNA repair.
    Title: PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.
  4. Bond formation and cleavage reactions catalyzed by base excision repair DNA polymerases beta and lambda has been described.
    Title: Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.
  5. When mutated or deregulated, DNA polymerase lambda can also be a source of genetic instability. Its multiple roles in DNA damage tolerance and its ability in promoting tumor progression make it also a possible target for novel anticancer approaches. [review]
    Title: Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.
  6. Data suggest that individuals who carry the rs3730477 POLL germline variant have an increased risk of estrogen-associated breast cancer.
    Title: Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.
  7. T204 was identified as a main target for ATM/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.
    Title: Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.
  8. The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conformation. Importantly, we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step and identify the residue responsible for this selectivity.
    Title: A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.
  9. Pol beta, to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.
    Title: Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.
  10. Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta, but not by the related enzyme Pol lambda.
    Title: Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2011-12-21)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2011-12-21)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-deoxyribose-5-phosphate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in base-excision repair, gap-filling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
  
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in somatic hypermutation of immunoglobulin genes NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase lambda
Names
DNA polymerase beta-2
DNA polymerase beta-N
DNA polymerase kappa
polymerase (DNA directed), lambda
polymerase (DNA) lambda
NP_001167555.1
NP_001167556.1
NP_001295311.1
NP_037406.1
XP_006717838.1
XP_006717840.1
XP_011537952.1
XP_011537953.1
XP_011537956.1
XP_011537957.1
XP_011537958.1
XP_011537959.1
XP_011537964.1
XP_011537966.1
XP_016871573.1
XP_016871574.1
XP_016871577.1
XP_016871579.1
XP_016871580.1
XP_024303710.1
XP_024303711.1
XP_024303713.2
XP_047281042.1
XP_047281043.1
XP_047281044.1
XP_047281045.1
XP_047281046.1
XP_047281047.1
XP_047281048.1
XP_047281049.1
XP_047281050.1
XP_047281051.1
XP_047281052.1
XP_047281053.1
XP_047281054.1
XP_054221561.1
XP_054221562.1
XP_054221563.1
XP_054221564.1
XP_054221565.1
XP_054221566.1
XP_054221567.1
XP_054221568.1
XP_054221569.1
XP_054221570.1
XP_054221571.1
XP_054221572.1
XP_054221573.1
XP_054221574.1
XP_054221575.1
XP_054221576.1
XP_054221577.1
XP_054221578.1
XP_054221579.1
XP_054221580.1
XP_054221581.1
XP_054221582.1
XP_054221583.1
XP_054221584.1
XP_054221585.1
XP_054221586.1
XP_054221587.1
XP_054221588.1
XP_054221589.1
XP_054221590.1
XP_054221591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017063.1 RefSeqGene

    Range
    5014..14389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174084.2 → NP_001167555.1  DNA polymerase lambda isoform a

    See identical proteins and their annotated locations for NP_001167555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AJ131890, BC068529, DC296090
    Consensus CDS
    CCDS7513.1
    UniProtKB/Swiss-Prot
    D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
    UniProtKB/TrEMBL
    Q9HAJ3
    Related
    ENSP00000359181.3, ENST00000370162.8
    Conserved Domains (2) summary
    cd00141
    Location:255 → 573
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:251 → 574
    POLXc; DNA polymerase X family

  2. NM_001174085.2 → NP_001167556.1  DNA polymerase lambda isoform b

    See identical proteins and their annotated locations for NP_001167556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform b, also known as lambda2), compared to isoform a.
    Source sequence(s)
    AK292225, BC068529, DC409528
    UniProtKB/TrEMBL
    A8K860, Q5QJV5
    Conserved Domains (1) summary
    cd00141
    Location:202 → 481
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  3. NM_001308382.2 → NP_001295311.1  DNA polymerase lambda isoform c

    See identical proteins and their annotated locations for NP_001295311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three exons in the 5' coding region, compared to variant 1. This results in the use of an alternate start codon and a frameshifted 5' coding region. The encoded isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF161019, BI906881, DA107389
    Consensus CDS
    CCDS76332.1
    UniProtKB/TrEMBL
    Q5JQP4
    Related
    ENSP00000485885.1, ENST00000628479.2
    Conserved Domains (1) summary
    cd00141
    Location:22 → 298
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  4. NM_013274.4 → NP_037406.1  DNA polymerase lambda isoform a

    See identical proteins and their annotated locations for NP_037406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AJ131890, BC068529, DC409528
    Consensus CDS
    CCDS7513.1
    UniProtKB/Swiss-Prot
    D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
    UniProtKB/TrEMBL
    Q9HAJ3
    Related
    ENSP00000299206.4, ENST00000299206.8
    Conserved Domains (2) summary
    cd00141
    Location:255 → 573
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:251 → 574
    POLXc; DNA polymerase X family

RNA

  1. NR_033406.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK022476, BC068529, DC379162

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101578882..101588270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425090.1 → XP_047281046.1  DNA polymerase lambda isoform X15

  2. XM_047425094.1 → XP_047281050.1  DNA polymerase lambda isoform X19

  3. XM_047425092.1 → XP_047281048.1  DNA polymerase lambda isoform X17

  4. XM_047425088.1 → XP_047281044.1  DNA polymerase lambda isoform X10

    UniProtKB/TrEMBL
    Q5JQP8
    Related
    ENSP00000359191.1, ENST00000370172.5

  5. XM_047425087.1 → XP_047281043.1  DNA polymerase lambda isoform X9

  6. XM_024447945.2 → XP_024303713.2  DNA polymerase lambda isoform X23

    UniProtKB/TrEMBL
    B4DE17

  7. XM_017016090.2 → XP_016871579.1  DNA polymerase lambda isoform X13

    Conserved Domains (1) summary
    cl00038
    Location:61 → 127
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

  8. XM_017016088.3 → XP_016871577.1  DNA polymerase lambda isoform X11

    Conserved Domains (1) summary
    cl00038
    Location:61 → 127
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

  9. XM_047425086.1 → XP_047281042.1  DNA polymerase lambda isoform X8

  10. XM_011539656.2 → XP_011537958.1  DNA polymerase lambda isoform X6

    UniProtKB/TrEMBL
    Q5QJV5
    Conserved Domains (1) summary
    cd00141
    Location:188 → 474
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  11. XM_011539655.2 → XP_011537957.1  DNA polymerase lambda isoform X4

    See identical proteins and their annotated locations for XP_011537957.1

    UniProtKB/TrEMBL
    A8K860, Q5QJV5
    Conserved Domains (1) summary
    cd00141
    Location:202 → 481
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  12. XM_011539654.2 → XP_011537956.1  DNA polymerase lambda isoform X3

    UniProtKB/TrEMBL
    Q5QJV5
    Related
    ENSP00000400676.1, ENST00000415897.5
    Conserved Domains (1) summary
    cd00141
    Location:202 → 488
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  13. XM_017016085.2 → XP_016871574.1  DNA polymerase lambda isoform X7

  14. XM_017016084.2 → XP_016871573.1  DNA polymerase lambda isoform X5

  15. XM_011539651.2 → XP_011537953.1  DNA polymerase lambda isoform X2

    See identical proteins and their annotated locations for XP_011537953.1

    UniProtKB/Swiss-Prot
    D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
    UniProtKB/TrEMBL
    Q9HAJ3
    Related
    ENSP00000359188.1, ENST00000370169.5
    Conserved Domains (2) summary
    cd00141
    Location:255 → 573
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:251 → 574
    POLXc; DNA polymerase X family

  16. XM_011539650.2 → XP_011537952.1  DNA polymerase lambda isoform X1

    See identical proteins and their annotated locations for XP_011537952.1

    UniProtKB/TrEMBL
    Q9HAJ3
    Conserved Domains (2) summary
    cd00141
    Location:255 → 580
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:251 → 581
    POLXc; DNA polymerase X family

  17. XM_011539657.2 → XP_011537959.1  DNA polymerase lambda isoform X9

    See identical proteins and their annotated locations for XP_011537959.1

    UniProtKB/TrEMBL
    Q9HAJ3
    Conserved Domains (1) summary
    cd00141
    Location:167 → 492
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  18. XM_047425095.1 → XP_047281051.1  DNA polymerase lambda isoform X20

  19. XM_047425093.1 → XP_047281049.1  DNA polymerase lambda isoform X18

  20. XM_047425091.1 → XP_047281047.1  DNA polymerase lambda isoform X16

  21. XM_024447943.2 → XP_024303711.1  DNA polymerase lambda isoform X10

    UniProtKB/TrEMBL
    Q5JQP8, Q9HAJ3
    Conserved Domains (1) summary
    cd00141
    Location:167 → 485
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  22. XM_024447942.2 → XP_024303710.1  DNA polymerase lambda isoform X9

    UniProtKB/TrEMBL
    Q9HAJ3
    Conserved Domains (1) summary
    cd00141
    Location:167 → 492
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  23. XM_006717777.3 → XP_006717840.1  DNA polymerase lambda isoform X28

    See identical proteins and their annotated locations for XP_006717840.1

    UniProtKB/TrEMBL
    Q5JQP4
    Related
    ENSP00000343102.3, ENST00000339310.7
    Conserved Domains (1) summary
    cd00141
    Location:22 → 298
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  24. XM_011539664.3 → XP_011537966.1  DNA polymerase lambda isoform X26

    See identical proteins and their annotated locations for XP_011537966.1

    UniProtKB/TrEMBL
    Q5JQP4
    Conserved Domains (1) summary
    cd00141
    Location:22 → 305
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  25. XM_006717775.3 → XP_006717838.1  DNA polymerase lambda isoform X25

    See identical proteins and their annotated locations for XP_006717838.1

    UniProtKB/TrEMBL
    B4DEF5
    Conserved Domains (1) summary
    cd00141
    Location:33 → 312
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  26. XM_011539662.3 → XP_011537964.1  DNA polymerase lambda isoform X24

    See identical proteins and their annotated locations for XP_011537964.1

    UniProtKB/TrEMBL
    B4DEF5
    Conserved Domains (1) summary
    cd00141
    Location:33 → 319
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

  27. XM_017016091.3 → XP_016871580.1  DNA polymerase lambda isoform X14

  28. XM_047425089.1 → XP_047281045.1  DNA polymerase lambda isoform X12

  29. XM_047425098.1 → XP_047281054.1  DNA polymerase lambda isoform X27

  30. XM_047425096.1 → XP_047281052.1  DNA polymerase lambda isoform X21

    Related
    ENSP00000400517.1, ENST00000413344.5

  31. XM_047425097.1 → XP_047281053.1  DNA polymerase lambda isoform X22

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102462924..102472307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365603.1 → XP_054221578.1  DNA polymerase lambda isoform X15

  2. XM_054365607.1 → XP_054221582.1  DNA polymerase lambda isoform X19

  3. XM_054365605.1 → XP_054221580.1  DNA polymerase lambda isoform X17

  4. XM_054365598.1 → XP_054221573.1  DNA polymerase lambda isoform X10

  5. XM_054365595.1 → XP_054221570.1  DNA polymerase lambda isoform X9

  6. XM_054365611.1 → XP_054221586.1  DNA polymerase lambda isoform X23

    UniProtKB/TrEMBL
    B4DE17

  7. XM_054365601.1 → XP_054221576.1  DNA polymerase lambda isoform X13

  8. XM_054365599.1 → XP_054221574.1  DNA polymerase lambda isoform X11

  9. XM_054365593.1 → XP_054221568.1  DNA polymerase lambda isoform X8

  10. XM_054365591.1 → XP_054221566.1  DNA polymerase lambda isoform X6

  11. XM_054365589.1 → XP_054221564.1  DNA polymerase lambda isoform X4

    UniProtKB/TrEMBL
    A8K860

  12. XM_054365588.1 → XP_054221563.1  DNA polymerase lambda isoform X3

  13. XM_054365592.1 → XP_054221567.1  DNA polymerase lambda isoform X7

  14. XM_054365590.1 → XP_054221565.1  DNA polymerase lambda isoform X5

  15. XM_054365587.1 → XP_054221562.1  DNA polymerase lambda isoform X2

  16. XM_054365586.1 → XP_054221561.1  DNA polymerase lambda isoform X1

  17. XM_054365596.1 → XP_054221571.1  DNA polymerase lambda isoform X9

  18. XM_054365608.1 → XP_054221583.1  DNA polymerase lambda isoform X20

  19. XM_054365606.1 → XP_054221581.1  DNA polymerase lambda isoform X18

  20. XM_054365604.1 → XP_054221579.1  DNA polymerase lambda isoform X16

  21. XM_054365597.1 → XP_054221572.1  DNA polymerase lambda isoform X10

  22. XM_054365594.1 → XP_054221569.1  DNA polymerase lambda isoform X9

  23. XM_054365616.1 → XP_054221591.1  DNA polymerase lambda isoform X28

  24. XM_054365614.1 → XP_054221589.1  DNA polymerase lambda isoform X26

  25. XM_054365613.1 → XP_054221588.1  DNA polymerase lambda isoform X25

  26. XM_054365612.1 → XP_054221587.1  DNA polymerase lambda isoform X24

  27. XM_054365602.1 → XP_054221577.1  DNA polymerase lambda isoform X14

  28. XM_054365600.1 → XP_054221575.1  DNA polymerase lambda isoform X12

  29. XM_054365615.1 → XP_054221590.1  DNA polymerase lambda isoform X27

  30. XM_054365609.1 → XP_054221584.1  DNA polymerase lambda isoform X21

  31. XM_054365610.1 → XP_054221585.1  DNA polymerase lambda isoform X22

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGP5.1 GenPept UniProtKB/Swiss-Prot:Q9UGP5

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