IL17C interleukin 17C [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL17Cprovided by HGNC
Official Full Name: interleukin 17Cprovided by HGNC
Primary source: HGNC:HGNC:5983
See related: Ensembl:ENSG00000124391 MIM:604628; AllianceGenome:HGNC:5983
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CX2; IL-17C
Summary: The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
Expression: Biased expression in endometrium (RPKM 1.7), gall bladder (RPKM 0.2) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (88638572..88640468)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (94706451..94708347)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (88704980..88706876)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-17C neutralization protects the kidney against acute injury and chronic injury.
Title: IL-17C neutralization protects the kidney against acute injury and chronic injury.
Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.
Title: Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.
Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
Title: Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
IL-17C expression and its correlation with pediatric adenoids: a preliminary study.
Title: IL-17C expression and its correlation with pediatric adenoids: a preliminary study.
Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.
Title: Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.
IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
Title: IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer.
Patients with acute Anti-neutrophil cytoplasmatic antibody (ANCA)-associated crescentic glomerulonephritis (GN) had significantly elevated serum levels of IL-17C.
Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
Study utilizing human skin samples, cultured primary human and mouse keratinocytes, and mouse disease models indicates that IL-17C is a central mediator of skin inflammation beyond psoriasis and is relevant in particular in atopic dermatitis.
Title: Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480908

NoName (e-PCR)
- UniSTS:485821

IL17C_1855 (e-PCR)
- UniSTS:280778

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-17C

Names: cytokine CX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.