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STK36 serine/threonine kinase 36 [ Homo sapiens (human) ]

Gene ID: 27148, updated on 7-Apr-2024

Summary

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Official Symbol
STK36provided by HGNC
Official Full Name
serine/threonine kinase 36provided by HGNC
Primary source
HGNC:HGNC:17209
See related
Ensembl:ENSG00000163482 MIM:607652; AllianceGenome:HGNC:17209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FU; CILD46
Summary
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 24.8), gall bladder (RPKM 6.4) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See STK36 in Genome Data Viewer
Location:
2q35
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218672086..218702717)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219158642..219189274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219536809..219567440)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17128 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:219563769-219564269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17129 Neighboring gene uncharacterized LOC124907983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12326 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:219584289-219584586 Neighboring gene tubulin tyrosine ligase like 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:219609538-219610737 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:219611731-219612930 Neighboring gene cytochrome P450 family 27 subfamily A member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect. Edelbusch C, et al. Hum Mutat, 2017 Aug. PMID 28543983
  2. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner NC, et al. EMBO J, 2008 May 7. PMID 18388863, Free PMC Article
  3. The FU gene and its possible protein isoforms. Østerlund T, et al. BMC Genomics, 2004 Jul 22. PMID 15268766, Free PMC Article
  4. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Katoh Y, et al. Int J Mol Med, 2006 Dec. PMID 17089004
  5. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, et al. J Cell Commun Signal, 2007 Dec. PMID 18600476, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer.
    Title: Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer.
  2. Data identified homozygous loss-of-function mutations in STK36 in one PCD-affected individual with situs solitus. Transmission electron microscopy analysis demonstrates that STK36 is required for cilia orientation in human respiratory epithelial cells, with a probable localization of STK36 between the RS and CP. STK36 screening can now be included for this rare and difficult to diagnose PCD subgroup.
    Title: Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.
  3. Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A protein complex with GLI3 activity control
    Title: The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
  4. The FU gene and its genomic structure was identified.
    Title: The FU gene and its possible protein isoforms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Ciliary dyskinesia, primary, 46
MedGen: C5543646 OMIM: 619436 GeneReviews: Not available
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EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1278, DKFZp434N0223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transcription corepressor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in post-embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 36
Names
fused homolog
testicular tissue protein Li 188
NP_001230242.1
NP_001356352.1
NP_056505.2
XP_011509261.1
XP_016859293.2
XP_047299887.1
XP_047299888.1
XP_054197357.1
XP_054197358.1
XP_054197359.1
XP_054197360.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029739.1 RefSeqGene

    Range
    5061..35690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243313.2 → NP_001230242.1  serine/threonine-protein kinase 36 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2, also known as L-FUdelta24) that is shorter than isoform 1.
    Source sequence(s)
    AA524236, AB033104
    Consensus CDS
    CCDS58750.1
    UniProtKB/Swiss-Prot
    Q9NRP7
    Related
    ENSP00000375954.3, ENST00000392105.7
    Conserved Domains (2) summary
    smart00220
    Location:4 → 254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

  2. NM_001369423.1 → NP_001356352.1  serine/threonine-protein kinase 36 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009974
    Consensus CDS
    CCDS2421.1
    UniProtKB/Swiss-Prot
    B7WPM3, Q8TC32, Q9H9N9, Q9NRP7, Q9UF35, Q9ULE2
    UniProtKB/TrEMBL
    A0A140VJW1
    Related
    ENSP00000394095.1, ENST00000440309.5
    Conserved Domains (1) summary
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

  3. NM_015690.5 → NP_056505.2  serine/threonine-protein kinase 36 isoform 1

    See identical proteins and their annotated locations for NP_056505.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as long form or L-FU).
    Source sequence(s)
    AA524236, AB033104, AF200815, DB062910
    Consensus CDS
    CCDS2421.1
    UniProtKB/Swiss-Prot
    B7WPM3, Q8TC32, Q9H9N9, Q9NRP7, Q9UF35, Q9ULE2
    UniProtKB/TrEMBL
    A0A140VJW1
    Related
    ENSP00000295709.3, ENST00000295709.8
    Conserved Domains (1) summary
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218672086..218702717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510959.3 → XP_011509261.1  serine/threonine-protein kinase 36 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:4 → 254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

  2. XM_047443932.1 → XP_047299888.1  serine/threonine-protein kinase 36 isoform X2

  3. XM_047443931.1 → XP_047299887.1  serine/threonine-protein kinase 36 isoform X1

  4. XM_017003804.3 → XP_016859293.2  serine/threonine-protein kinase 36 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219158642..219189274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341382.1 → XP_054197357.1  serine/threonine-protein kinase 36 isoform X1

  2. XM_054341384.1 → XP_054197359.1  serine/threonine-protein kinase 36 isoform X2

  3. XM_054341383.1 → XP_054197358.1  serine/threonine-protein kinase 36 isoform X1

  4. XM_054341385.1 → XP_054197360.1  serine/threonine-protein kinase 36 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRP7.2 GenPept UniProtKB/Swiss-Prot:Q9NRP7

Gene LinkOut

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