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FETUB fetuin B [ Homo sapiens (human) ]

Gene ID: 26998, updated on 5-Mar-2024

Summary

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Official Symbol
FETUBprovided by HGNC
Official Full Name
fetuin Bprovided by HGNC
Primary source
HGNC:HGNC:3658
See related
Ensembl:ENSG00000090512 MIM:605954; AllianceGenome:HGNC:3658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
16G2; Gugu; IRL685
Summary
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 42.7) See more
Orthologs
mouse all
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Genomic context

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Location:
3q27.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (186635969..186653141)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (189451683..189468852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186353758..186370930)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9080 Neighboring gene PET100 pseudogene 1 Neighboring gene alpha 2-HS glycoprotein Neighboring gene HRG and FETUB antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:186375416-186375935 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:186380938-186381618 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:186386725-186387924 Neighboring gene histidine rich glycoprotein Neighboring gene HRG pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathway. Zhan K, et al. Biomed Pharmacother, 2020 Nov. PMID 32892030
  2. Fetuin-B regulates vascular plaque rupture via TGF-β receptor-mediated Smad pathway in vascular smooth muscle cells. Jung SH, et al. Pflugers Arch, 2020 May. PMID 32382986
  3. Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults. Li Z, et al. J Atheroscler Thromb, 2020 May 1. PMID 31527322, Free PMC Article
  4. Serum and follicular fluid fetuin-B levels are correlated with fertilization rates in conventional IVF cycles. Fang L, et al. J Assist Reprod Genet, 2019 Jun. PMID 31073723, Free PMC Article
  5. Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes. El-Ashmawy HM, et al. Eur J Gastroenterol Hepatol, 2019 Jul. PMID 30601337

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-kappaB Signaling Pathway.
    Title: Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway.
  2. Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity.
    Title: Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity.
  3. Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.
    Title: Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.
  4. Fetuin-B regulates vascular plaque rupture via TGF-beta receptor-mediated Smad pathway in vascular smooth muscle cells.
    Title: Fetuin-B regulates vascular plaque rupture via TGF-β receptor-mediated Smad pathway in vascular smooth muscle cells.
  5. Fetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathway.
    Title: Fetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathway.
  6. The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
    Title: The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
  7. Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes.
    Title: Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes.
  8. Serum fetuin-B level is correlated with fertilization rate in conventional IVF and it may be used as a predictive marker of fertilization in IVF treatment.
    Title: Serum and follicular fluid fetuin-B levels are correlated with fertilization rates in conventional IVF cycles.
  9. High Fetuin B expression is associated with vitamin D deficiency and pediatric obesity.
    Title: Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D.
  10. Fetuin-B links nonalcoholic fatty liver disease (NAFLD) to type 2 diabetes (T2D) via inducing insulin resistance, and NAFLD contributes to the pathogenesis of T2D via multiple mechanisms.
    Title: Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 binds to the natural glycoprotein fetuin PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fetuin-B
Names
fetuin-like protein IRL685

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308077.4 → NP_001295006.1  fetuin-B isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS82884.1
    UniProtKB/TrEMBL
    Q5J875
    Related
    ENSP00000371571.3, ENST00000382136.3
    Conserved Domains (1) summary
    smart00043
    Location:113 → 218
    CY; Cystatin-like domain

  2. NM_001308079.4 → NP_001295008.1  fetuin-B isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS77871.1
    UniProtKB/TrEMBL
    E9PG08, Q5J875
    Related
    ENSP00000371569.3, ENST00000382134.7
    Conserved Domains (1) summary
    smart00043
    Location:85 → 190
    CY; Cystatin-like domain

  3. NM_001375587.2 → NP_001362516.1  fetuin-B isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Consensus CDS
    CCDS3279.1
    UniProtKB/Swiss-Prot
    B2RCW6, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9UGM5, Q9Y6Z0
    UniProtKB/TrEMBL
    Q5J875
    Related
    ENSP00000404288.1, ENST00000450521.5
    Conserved Domains (1) summary
    smart00043
    Location:150 → 255
    CY; Cystatin-like domain

  4. NM_001375588.2 → NP_001362517.1  fetuin-B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC068631
    Conserved Domains (1) summary
    smart00043
    Location:45 → 150
    CY; Cystatin-like domain

  5. NM_001375589.2 → NP_001362518.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    UniProtKB/TrEMBL
    B7Z8T3
    Conserved Domains (1) summary
    smart00043
    Location:2 → 107
    CY; Cystatin-like domain

  6. NM_001375590.2 → NP_001362519.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    UniProtKB/TrEMBL
    B7Z8T3
    Conserved Domains (1) summary
    smart00043
    Location:2 → 107
    CY; Cystatin-like domain

  7. NM_001375591.2 → NP_001362520.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    UniProtKB/TrEMBL
    B7Z8T3
    Conserved Domains (1) summary
    smart00043
    Location:2 → 107
    CY; Cystatin-like domain

  8. NM_001375592.2 → NP_001362521.1  fetuin-B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068631
    UniProtKB/TrEMBL
    B7Z8T3
    Conserved Domains (1) summary
    smart00043
    Location:2 → 107
    CY; Cystatin-like domain

  9. NM_014375.3 → NP_055190.2  fetuin-B isoform 1 precursor

    See identical proteins and their annotated locations for NP_055190.2

    Status: REVIEWED

    Source sequence(s)
    AC068631, AJ242928, BC069670, BX115543
    Consensus CDS
    CCDS3279.1
    UniProtKB/Swiss-Prot
    B2RCW6, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9UGM5, Q9Y6Z0
    UniProtKB/TrEMBL
    Q5J875
    Related
    ENSP00000265029.3, ENST00000265029.8
    Conserved Domains (1) summary
    smart00043
    Location:150 → 255
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    186635969..186653141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    189451683..189468852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGM5.2 GenPept UniProtKB/Swiss-Prot:Q9UGM5

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