HS6ST3 heparan sulfate 6-O-sulfotransferase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HS6ST3provided by HGNC
Official Full Name: heparan sulfate 6-O-sulfotransferase 3provided by HGNC
Primary source: HGNC:HGNC:19134
See related: Ensembl:ENSG00000185352 MIM:609401; AllianceGenome:HGNC:19134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HS6ST-3
Summary: Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in brain (RPKM 5.5), urinary bladder (RPKM 1.6) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (96090107..96839562)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (95294349..96043658)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (96742361..97491816)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing HS6ST3 diminished tumor cell growth and progression in breast cancer cells. Silencing HS6ST3 down-regulated IGF1R and up-regulated XAF1.
Title: Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1.
Single-nucleotide polymorphisms within the HS6ST3 gene are associated with obesity and triglyceride levels. [Meta-analysis]
Title: Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of diabetic retinopathy in a Taiwanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-68276 (e-PCR)
- UniSTS:100616

D13S1280 (e-PCR), detects polymorphism
- UniSTS:18488

SHGC-146476 (e-PCR)
- UniSTS:172616

SHGC-146494 (e-PCR)
- UniSTS:172620

G44302 (e-PCR)
- UniSTS:95096

RH77922 (e-PCR)
- UniSTS:383

SHGC-8118 (e-PCR)
- UniSTS:75393

Hs6st3 (e-PCR), detects polymorphism
- UniSTS:532612

G17704 (e-PCR)
- UniSTS:14981

SHGC-149555 (e-PCR)
- UniSTS:182698

WI-14918 (e-PCR)
- UniSTS:53163

SHGC-155001 (e-PCR)
- UniSTS:182717

D13S254 (e-PCR)
- UniSTS:69566

A002U05 (e-PCR)
- UniSTS:41693

D13S132 (e-PCR)
- UniSTS:79589

RH78584 (e-PCR)
- UniSTS:2283

G60459 (e-PCR)
- UniSTS:137715

D13S877E (e-PCR)
- UniSTS:151540

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heparan sulfate 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan-sulfate 6-O-sulfotransferase 3

NP_703157.2

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.