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CKAP2 cytoskeleton associated protein 2 [ Homo sapiens (human) ]

Gene ID: 26586, updated on 3-Apr-2024

Summary

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Official Symbol
CKAP2provided by HGNC
Official Full Name
cytoskeleton associated protein 2provided by HGNC
Primary source
HGNC:HGNC:1990
See related
Ensembl:ENSG00000136108 MIM:611569; AllianceGenome:HGNC:1990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LB1; TMAP; se20-10
Summary
This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Expression
Broad expression in bone marrow (RPKM 15.6), testis (RPKM 14.9) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
13q14.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52455478..52476627)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51670301..51692112)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53029613..53050762)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53024355-53024935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7791 Neighboring gene CKAP2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene TPTE2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 15313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma. Zhang S, et al. Medicine (Baltimore), 2022 Jul 29. PMID 35905213, Free PMC Article
  2. Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells. Zhang S, et al. Biomed Pharmacother, 2018 Oct. PMID 30119212
  3. CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma. Wang K, et al. Oncol Rep, 2018 Oct. PMID 30066946, Free PMC Article
  4. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Guo QS, et al. Sci Rep, 2017 May 18. PMID 28522860, Free PMC Article
  5. Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer. Kim HS, et al. PLoS One, 2014. PMID 24887265, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
    Title: CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
  2. Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
    Title: Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2.
  3. LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
    Title: LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
  4. Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
    Title: Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
  5. CKAP2 acts as a functional oncogene in cervical carcinoma development and may exert its function by targeting FAK-ERK2 signaling pathway.
    Title: Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines.
  6. Knockdown of CKAP2 expression effectively suppressed the proliferation and induced the apoptosis by inhibiting the phosphorylation of JAK2/STAT3 of osteosarcoma cells.
    Title: Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells.
  7. High CKAP2 expression is associated with highgrade glioma.
    Title: CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma.
  8. High CKAP2 expression is associated with Ovarian Cancer.
    Title: CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway.
  9. Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.
    Title: Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer.
  10. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.
    Title: RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10749, DKFZp686L1238

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoskeleton-associated protein 2
Names
CTCL tumor antigen se20-10
tumor- and microtubule-associated protein
tumor-associated microtubule-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098525.3 → NP_001091995.1  cytoskeleton-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001091995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AI499799, AY062261, EC439890, Y15758
    Consensus CDS
    CCDS41893.1
    UniProtKB/Swiss-Prot
    A2BDE0, A5YM58, B4DR35, E9PD90, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q8WWK9, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4
    UniProtKB/TrEMBL
    B2RMQ4
    Related
    ENSP00000367276.4, ENST00000378037.9
    Conserved Domains (1) summary
    pfam15297
    Location:326 → 673
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  2. NM_001286686.2 → NP_001273615.1  cytoskeleton-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI499799, AK299083, AY062261, EC439890
    Consensus CDS
    CCDS66557.1
    UniProtKB/TrEMBL
    B2RMQ4
    Related
    ENSP00000417830.1, ENST00000490903.5
    Conserved Domains (1) summary
    pfam15297
    Location:277 → 624
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  3. NM_001286687.2 → NP_001273616.1  cytoskeleton-associated protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001273616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as CKAP2-s) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA308726, AY062262
    Consensus CDS
    CCDS73578.1
    UniProtKB/Swiss-Prot
    Q8WWK9
    Related
    ENSP00000367273.2, ENST00000378034.7
    Conserved Domains (1) summary
    pfam15297
    Location:325 → 492
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  4. NM_018204.5 → NP_060674.3  cytoskeleton-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060674.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI499799, AK022982, AY062261, EC439890
    Consensus CDS
    CCDS9435.1
    UniProtKB/TrEMBL
    B2RMQ4
    Related
    ENSP00000258607.5, ENST00000258607.10
    Conserved Domains (1) summary
    pfam15297
    Location:325 → 672
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    52455478..52476627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266344.5 → XP_005266401.1  cytoskeleton-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RMQ4
    Conserved Domains (1) summary
    pfam15297
    Location:278 → 625
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  2. XM_047430268.1 → XP_047286224.1  cytoskeleton-associated protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    51670301..51692112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374449.1 → XP_054230424.1  cytoskeleton-associated protein 2 isoform X1

  2. XM_054374450.1 → XP_054230425.1  cytoskeleton-associated protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWK9.1 GenPept UniProtKB/Swiss-Prot:Q8WWK9

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