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SRPK3 SRSF protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 26576, updated on 5-Mar-2024

Summary

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Official Symbol
SRPK3provided by HGNC
Official Full Name
SRSF protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:11402
See related
Ensembl:ENSG00000184343 MIM:301002; AllianceGenome:HGNC:11402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSSK1; STK23; MSSK-1
Summary
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues See more
Orthologs
mouse all
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Genomic context

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See SRPK3 in Genome Data Viewer
Location:
Xq28
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153781041..153785730)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152054705..152059393)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153046496..153051185)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905226 Neighboring gene ATP binding cassette subfamily D member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153005935-153006435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153008185-153008886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153008887-153009586 Neighboring gene PLXNB3 antisense RNA 1 Neighboring gene plexin B3 Neighboring gene uncharacterized LOC124905227 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153059193-153059920 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene CRISPRi-validated cis-regulatory element chrX.2654 Neighboring gene signal sequence receptor subunit 4 Neighboring gene PDZ domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21072 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:153092379-153092957

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells. Zhang M, et al. J Biol Chem, 2015 Jan 2. PMID 25404735, Free PMC Article
  2. Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. Grunau C, et al. Hum Mol Genet, 2000 Nov 1. PMID 11063724
  3. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa O, et al. Genes Dev, 2005 Sep 1. PMID 16140986, Free PMC Article
  4. Regulation of alternative splicing by SRrp86 and its interacting proteins. Li J, et al. Mol Cell Biol, 2003 Nov. PMID 14559993, Free PMC Article
  5. Human gingiva transcriptome during wound healing. Wang Y, et al. J Clin Periodontol, 2017 Apr. PMID 28005267

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRPK3 expression is significantly downregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  2. Alternative splicing of the alpha-exon of MEF2C regulates myogenesis. Loss of SRPK3 in rhabdomyosarcoma cells inhibits this splicing and blocks differentiation.
    Title: Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of SRSF protein kinase 3 (SRPK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PLXNB3

Homology

Clone Names

  • MGC102944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SRSF protein kinase 3
Names
SFRS protein kinase 3
SR-protein-specific kinase 3
muscle-specific serine kinase 1
serine arginine rich protein-specific kinase 3
serine/threonine kinase 23
serine/threonine-protein kinase 23
serine/threonine-protein kinase SRPK3
NP_001164231.1
NP_001164232.1
NP_055185.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016329.1 RefSeqGene

    Range
    5041..9730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170760.2 → NP_001164231.1  SRSF protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001164231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    BC117124, U52111
    Consensus CDS
    CCDS55538.1
    UniProtKB/TrEMBL
    A8MPY5
    Related
    ENSP00000359122.1, ENST00000370104.5
    Conserved Domains (1) summary
    cd14218
    Location:68 → 564
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

  2. NM_001170761.2 → NP_001164232.1  SRSF protein kinase 3 isoform 3

    See identical proteins and their annotated locations for NP_001164232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AF027406, U52111
    Consensus CDS
    CCDS55537.1
    UniProtKB/TrEMBL
    A8MPY5
    Related
    ENSP00000377376.3, ENST00000393786.7
    Conserved Domains (2) summary
    smart00220
    Location:79 → 531
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:68 → 531
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

  3. NM_014370.4 → NP_055185.2  SRSF protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_055185.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC092416, U52111
    Consensus CDS
    CCDS35441.1
    UniProtKB/Swiss-Prot
    Q13583, Q4F970, Q562F5, Q9UM62, Q9UPE1
    UniProtKB/TrEMBL
    A8MPY5
    Related
    ENSP00000359119.3, ENST00000370101.8
    Conserved Domains (2) summary
    smart00220
    Location:79 → 565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:68 → 565
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    153781041..153785730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152054705..152059393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPE1.2 GenPept UniProtKB/Swiss-Prot:Q9UPE1

Gene LinkOut

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