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GAPVD1 GTPase activating protein and VPS9 domains 1 [ Homo sapiens (human) ]

Gene ID: 26130, updated on 7-Apr-2024

Summary

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Official Symbol
GAPVD1provided by HGNC
Official Full Name
GTPase activating protein and VPS9 domains 1provided by HGNC
Primary source
HGNC:HGNC:23375
See related
Ensembl:ENSG00000165219 MIM:611714; AllianceGenome:HGNC:23375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAP6; GAPEX5; GAPex-5
Summary
Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 9.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See GAPVD1 in Genome Data Viewer
Location:
9q33.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (125261826..125367207)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137460127..137566391)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (128024105..128129486)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:128003252-128003756 and GRCh37_chr9:128003757-128004261 Neighboring gene Sharpr-MPRA regulatory region 12295 Neighboring gene HSPA5 divergent transcript Neighboring gene heat shock protein family A (Hsp70) member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128020420-128020678 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128024002-128024183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:128029981-128030481 Neighboring gene ribosomal protein S10 pseudogene 17 Neighboring gene RNA, U6 small nuclear 1020, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128115126-128115299 Neighboring gene Sharpr-MPRA regulatory region 13338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128133357-128133857 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:128152293-128153032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:128169974-128170568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29002 Neighboring gene uncharacterized LOC101929014 Neighboring gene uncharacterized LOC112268055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128186118-128186618 Neighboring gene RNA, U5B small nuclear 5, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis. Khademi B, et al. J Neuroimmunol, 2021 Apr 15. PMID 33548618
  2. Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation. Ibrahim H, et al. Int J Mol Sci, 2021 Apr 6. PMID 33917494, Free PMC Article
  3. Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. Hunker CM, et al. Biochem Biophys Res Commun, 2006 Feb 17. PMID 16410077
  4. Interaction of Plasmodium falciparum casein kinase 1 with components of host cell protein trafficking machinery. Batty MB, et al. IUBMB Life, 2020 Jun. PMID 32356940
  5. CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1. Guillen RX, et al. Sci Rep, 2020 Apr 22. PMID 32321936, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
    Title: An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
  2. Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
    Title: Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
  3. CRISPR-mediated gene targeting of CK1delta/epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.
    Title: CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.
  4. The findings suggest that SPIN90, as an adaptor protein, simultaneously binds inactive Rab5 and Gapex5, thereby altering their spatial proximity and facilitating Rab5 activation.
    Title: SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis.
  5. EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation
    Title: GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of GAPVD1 PubMed
Knockdown of GTPase activating protein and VPS9 domains 1 (GAPVD1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1521, MGC138847, MGC138848, DKFZp434C212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activating protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
GTPase-activating protein and VPS9 domain-containing protein 1
Names
Rab5 exchange factor
Rab5-activating protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282679.2 → NP_001269608.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001269608.1

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65132.1
    UniProtKB/Swiss-Prot
    A8MYK3, B0QZ62, B0QZ63, B0QZ64, Q14C76, Q14C86, Q2Q1W1, Q8ND92, Q8WU86, Q96CZ4, Q9NXQ1, Q9P207, Q9Y4N0
    Related
    ENSP00000419063.1, ENST00000495955.5
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1374 → 1475
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1263 → 1326
    DUF5601; Domain of unknown function (DUF5601)

  2. NM_001282680.3 → NP_001269609.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001269609.1

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Related
    ENSP00000297933.6, ENST00000297933.11
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  3. NM_001282681.3 → NP_001269610.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001269610.1

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65130.1
    UniProtKB/Swiss-Prot
    Q14C86
    Related
    ENSP00000309582.9, ENST00000312123.13
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1335 → 1436
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1224 → 1287
    DUF5601; Domain of unknown function (DUF5601)

  4. NM_001330777.3 → NP_001317706.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS83413.1
    UniProtKB/TrEMBL
    F8W9S7
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1308 → 1409
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1197 → 1260
    DUF5601; Domain of unknown function (DUF5601)

  5. NM_001330778.3 → NP_001317707.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS83414.1
    Related
    ENSP00000419767.1, ENST00000470056.5
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1329 → 1430
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1218 → 1281
    DUF5601; Domain of unknown function (DUF5601)

  6. NM_001354293.2 → NP_001341222.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AA683411, AL354710, BC110990
    Consensus CDS
    CCDS87689.1
    UniProtKB/TrEMBL
    B0QZ65
    Related
    ENSP00000377646.1, ENST00000394084.5
    Conserved Domains (1) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6

  7. NM_001354294.2 → NP_001341223.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  8. NM_001354295.2 → NP_001341224.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  9. NM_001354296.2 → NP_001341225.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  10. NM_001354297.2 → NP_001341226.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65130.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1335 → 1436
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1224 → 1287
    DUF5601; Domain of unknown function (DUF5601)

  11. NM_001354298.2 → NP_001341227.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  12. NM_001354299.2 → NP_001341228.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  13. NM_001354300.2 → NP_001341229.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65130.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1335 → 1436
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1224 → 1287
    DUF5601; Domain of unknown function (DUF5601)

  14. NM_001354301.2 → NP_001341230.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS65131.1
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  15. NM_015635.4 → NP_056450.2  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_056450.2

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223
    Consensus CDS
    CCDS35138.1
    Related
    ENSP00000377665.2, ENST00000394105.6
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1383 → 1484
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1272 → 1335
    DUF5601; Domain of unknown function (DUF5601)

RNA

  1. NR_148732.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223

  2. NR_148733.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL354710, AL627223

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    125261826..125367207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423183.1 → XP_047279139.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  2. XM_047423204.1 → XP_047279160.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  3. XM_047423182.1 → XP_047279138.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  4. XM_047423193.1 → XP_047279149.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  5. XM_047423205.1 → XP_047279161.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  6. XM_047423200.1 → XP_047279156.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  7. XM_047423180.1 → XP_047279136.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  8. XM_047423189.1 → XP_047279145.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  9. XM_047423194.1 → XP_047279150.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  10. XM_047423207.1 → XP_047279163.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7

  11. XM_047423181.1 → XP_047279137.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  12. XM_047423202.1 → XP_047279158.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  13. XM_047423186.1 → XP_047279142.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  14. XM_047423195.1 → XP_047279151.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  15. XM_047423208.1 → XP_047279164.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7

  16. XM_047423179.1 → XP_047279135.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  17. XM_047423190.1 → XP_047279146.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  18. XM_047423196.1 → XP_047279152.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  19. XM_047423177.1 → XP_047279133.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  20. XM_047423201.1 → XP_047279157.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  21. XM_047423187.1 → XP_047279143.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  22. XM_011518500.3 → XP_011516802.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516802.1

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1383 → 1484
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1272 → 1335
    DUF5601; Domain of unknown function (DUF5601)

  23. XM_047423192.1 → XP_047279148.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

  24. XM_017014609.2 → XP_016870098.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1329 → 1430
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1218 → 1281
    DUF5601; Domain of unknown function (DUF5601)

  25. XM_047423185.1 → XP_047279141.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  26. XM_047423198.1 → XP_047279154.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

  27. XM_017014606.2 → XP_016870095.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q14C86
    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1335 → 1436
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1224 → 1287
    DUF5601; Domain of unknown function (DUF5601)

  28. XM_011518499.3 → XP_011516801.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516801.1

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1383 → 1484
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1272 → 1335
    DUF5601; Domain of unknown function (DUF5601)

  29. XM_011518507.3 → XP_011516809.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1356 → 1457
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1245 → 1308
    DUF5601; Domain of unknown function (DUF5601)

  30. XM_005251904.4 → XP_005251961.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    See identical proteins and their annotated locations for XP_005251961.1

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1329 → 1430
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1218 → 1281
    DUF5601; Domain of unknown function (DUF5601)

  31. XM_011518506.3 → XP_011516808.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    cd05129
    Location:84 → 449
    RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
    pfam02204
    Location:1362 → 1463
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    pfam18151
    Location:1251 → 1314
    DUF5601; Domain of unknown function (DUF5601)

  32. XM_047423178.1 → XP_047279134.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  33. XM_047423191.1 → XP_047279147.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  34. XM_047423203.1 → XP_047279159.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  35. XM_047423188.1 → XP_047279144.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  36. XM_047423197.1 → XP_047279153.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  37. XM_047423209.1 → XP_047279165.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7

  38. XM_047423184.1 → XP_047279140.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  39. XM_047423199.1 → XP_047279155.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

  40. XM_047423206.1 → XP_047279162.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7
    Related
    ENSP00000377645.2, ENST00000394083.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    137460127..137566391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362667.1 → XP_054218642.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  2. XM_054362666.1 → XP_054218641.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  3. XM_054362678.1 → XP_054218653.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  4. XM_054362693.1 → XP_054218668.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  5. XM_054362686.1 → XP_054218661.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  6. XM_054362664.1 → XP_054218639.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  7. XM_054362673.1 → XP_054218648.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  8. XM_054362680.1 → XP_054218655.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  9. XM_054362695.1 → XP_054218670.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7

  10. XM_054362665.1 → XP_054218640.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  11. XM_054362691.1 → XP_054218666.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  12. XM_054362671.1 → XP_054218646.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  13. XM_054362681.1 → XP_054218656.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  14. XM_054362696.1 → XP_054218671.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7

  15. XM_054362663.1 → XP_054218638.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  16. XM_054362674.1 → XP_054218649.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  17. XM_054362682.1 → XP_054218657.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  18. XM_054362661.1 → XP_054218636.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  19. XM_054362690.1 → XP_054218665.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  20. XM_054362672.1 → XP_054218647.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  21. XM_054362687.1 → XP_054218662.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  22. XM_054362660.1 → XP_054218635.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  23. XM_054362677.1 → XP_054218652.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

  24. XM_054362688.1 → XP_054218663.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  25. XM_054362670.1 → XP_054218645.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  26. XM_054362684.1 → XP_054218659.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

  27. XM_054362679.1 → XP_054218654.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  28. XM_054362659.1 → XP_054218634.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  29. XM_054362676.1 → XP_054218651.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

  30. XM_054362689.1 → XP_054218664.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  31. XM_054362668.1 → XP_054218643.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  32. XM_054362662.1 → XP_054218637.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

  33. XM_054362675.1 → XP_054218650.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

  34. XM_054362692.1 → XP_054218667.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

  35. XM_054362683.1 → XP_054218658.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

  36. XM_054362669.1 → XP_054218644.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

  37. XM_054362685.1 → XP_054218660.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

  38. XM_054362694.1 → XP_054218669.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    F8W9S7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14C86.2 GenPept UniProtKB/Swiss-Prot:Q14C86

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