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PART1 prostate androgen-regulated transcript 1 [ Homo sapiens (human) ]

Gene ID: 25859, updated on 13-Nov-2023

Summary

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Official Symbol
PART1provided by HGNC
Official Full Name
prostate androgen-regulated transcript 1provided by HGNC
Primary source
HGNC:HGNC:17263
See related
Ensembl:ENSG00000152931 MIM:604991; AllianceGenome:HGNC:17263
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRNA00206
Summary
This gene is induced by androgen in prostate adenocarcinoma cells. Multiple alternatively transcript variants have been described for this gene, none of which are predicted to encode a protein product. [provided by RefSeq, Sep 2009]
Expression
Biased expression in brain (RPKM 4.1), prostate (RPKM 3.9) and 5 other tissues See more
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Genomic context

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See PART1 in Genome Data Viewer
Location:
5q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (60487713..60547657)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (61306025..61365980)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (59783540..59843484)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22587 Neighboring gene Sharpr-MPRA regulatory region 9229 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene Sharpr-MPRA regulatory region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16038 Neighboring gene uncharacterized LOC124900982 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non‑coding RNA PART1: dual role in cancer. Ran R, et al. Hum Cell, 2022 Sep. PMID 35864416
  2. The Role of Tumor-related LncRNA PART1 in Cancer. Chen J, et al. Curr Pharm Des, 2021. PMID 34225608
  3. YY1-Induced lncRNA PART1 Enhanced Resistance of Ovarian Cancer Cells to Cisplatin by Regulating miR-512-3p/CHRAC1 Axis. Yang H, et al. DNA Cell Biol, 2021 Jun. PMID 34030482
  4. LncRNA PART1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking EZH2 degradation. Yu Q, et al. J Biochem, 2021 Sep 7. PMID 33725092
  5. Silencing of lncRNA PART1 inhibits proliferation, invasion and migration of breast cancer cells and promotes the efficacy of cisplatin in breast cancer cells. Zhang L, et al. Gen Physiol Biophys, 2020 Jul. PMID 32700682

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis.
    Title: LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis.
  2. Exosome-mediated long noncoding RNA (lncRNA) PART1 suppresses malignant progression of oral squamous cell carcinoma via miR-17-5p/SOCS6 axis.
    Title: Exosome-mediated long noncoding RNA (lncRNA) PART1 suppresses malignant progression of oral squamous cell carcinoma via miR-17-5p/SOCS6 axis.
  3. Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.
    Title: Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.
  4. Long noncoding RNA PART1: dual role in cancer.
    Title: Long non‑coding RNA PART1: dual role in cancer.
  5. LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
    Title: LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
  6. LncRNA PART1/miR-185-5p/RUNX3 feedback loop modulates osteogenic differentiation of bone marrow mesenchymal stem cells.
    Title: LncRNA PART1/miR-185-5p/RUNX3 feedback loop modulates osteogenic differentiation of bone marrow mesenchymal stem cells.
  7. The Role of Tumor-related LncRNA PART1 in Cancer.
    Title: The Role of Tumor-related LncRNA PART1 in Cancer.
  8. PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
    Title: PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
  9. lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR18a5p/SOX6 signaling axis.
    Title: lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis.
  10. LncRNA PART1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking EZH2 degradation.
    Title: LncRNA PART1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking EZH2 degradation.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • prostate androgen-regulated transcript 1 (non-protein coding)
  • prostate-specific and androgen-regulated cDNA 14D7 protein

Clone Names

  • DKFZp586D0823

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024617.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains different segments for its 3' end, compared to variant 3.
    Source sequence(s)
    AK094518, AK312071, BC069304

  2. NR_028508.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 3' end, compared to variant 3.
    Source sequence(s)
    AF163475, BQ898163
    Related
    ENST00000515734.2

  3. NR_028509.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript.
    Source sequence(s)
    AC016591, AF070547, AF163475
    Related
    ENST00000661844.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    60487713..60547657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    61306025..61365980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039499.1: Suppressed sequence

    Description
    NM_001039499.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001040639.1: Suppressed sequence

    Description
    NM_001040639.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version

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