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ARMC8 armadillo repeat containing 8 [ Homo sapiens (human) ]

Gene ID: 25852, updated on 3-Apr-2024

Summary

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Official Symbol
ARMC8provided by HGNC
Official Full Name
armadillo repeat containing 8provided by HGNC
Primary source
HGNC:HGNC:24999
See related
Ensembl:ENSG00000114098 MIM:618521; AllianceGenome:HGNC:24999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GID5; VID28; S863-2; HSPC056
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 8.0), thyroid (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q22.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138187248..138298389)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (140927839..141038955)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137906090..138017231)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene OCT4 hESC enhancer GRCh37_chr3:137879291-137879792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20601 Neighboring gene debranching RNA lariats 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20602 Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC124909438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:138066933-138067888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:138078932-138079766 Neighboring gene MPRA-validated peak4844 silencer Neighboring gene muscle RAS oncogene homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells. Jiang F, et al. Oncol Res, 2016. PMID 27712595, Free PMC Article
  2. Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex. Zhao Y, et al. Tumour Biol, 2016 Aug. PMID 26944057
  3. A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer. Jiang G, et al. Hum Pathol, 2015 Oct. PMID 26232863
  4. ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells. Jiang G, et al. Tumour Biol, 2015 Nov. PMID 26081621
  5. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. Fan C, et al. Tumour Biol, 2014 Nov. PMID 25119601

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-455-3p inhibits gastric cancer progression by repressing Wnt/beta-catenin signaling through binding to ARMC8.
    Title: MiR-455-3p inhibits gastric cancer progression by repressing Wnt/β-catenin signaling through binding to ARMC8.
  2. Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/beta-catenin pathway and EMT in cutaneous squamous cell carcinomas.
    Title: Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas.
  3. Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.
    Title: Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.
  4. Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial-mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells.
    Title: Armadillo Repeat-Containing Protein 8 (ARMC8) Silencing Inhibits Proliferation and Invasion in Osteosarcoma Cells.
  5. results indicate that Armc8 may be a potential cancer marker in hepatocellular carcinoma
    Title: Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex.
  6. invasiveness and migration capacity of HT29 cells transfected with ARMc8 were significantly greater than those of control cells (p < 0.001), while ARMc8 siRNA treatment significantly reduced cell invasion and migration in LoVo cells
    Title: ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells.
  7. ARMc8 may enhance the invasion and metastasis of ovarian cancer cells
    Title: A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer.
  8. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.
    Title: Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma.
  9. Data suggest that armadillo repeat containing protein 8 (ARMC8) might serve as a therapeutic target in non-small cell lung cancer (NSCLC).
    Title: ARMC8α promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway.
  10. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells
    Title: RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4880, MGC10058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
armadillo repeat-containing protein 8
Names
GID complex subunit 5, VID28 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267041.2 → NP_001253970.1  armadillo repeat-containing protein 8 isoform 3

    See identical proteins and their annotated locations for NP_001253970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK296837, AK299769, AL096748, BQ014283, HY004298
    Consensus CDS
    CCDS58854.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    UniProtKB/TrEMBL
    B7Z637
    Related
    ENSP00000441592.1, ENST00000538260.5
    Conserved Domains (4) summary
    COG5064
    Location:22 → 181
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:343 → 576
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:522 → 552
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  2. NM_001267042.3 → NP_001253971.1  armadillo repeat-containing protein 8 isoform 4

    See identical proteins and their annotated locations for NP_001253971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK296757, AL096748, BQ014283, CX167429
    Consensus CDS
    CCDS58853.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000420706.1, ENST00000461822.5
    Conserved Domains (4) summary
    COG5064
    Location:28 → 414
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:307 → 540
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:486 → 516
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  3. NM_001282342.2 → NP_001269271.1  armadillo repeat-containing protein 8 isoform 5

    See identical proteins and their annotated locations for NP_001269271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of a downstream start codon, compared to variant 1. The encoded isoform (5) is longer and has a shorter N-terminus and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK299769, AL096748, BQ014283
    Consensus CDS
    CCDS75020.1
    UniProtKB/TrEMBL
    B7Z5P0, B7Z637
    Related
    ENSP00000417049.1, ENST00000485396.5
    Conserved Domains (4) summary
    COG5064
    Location:3 → 139
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:301 → 534
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:480 → 510
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  4. NM_001363941.2 → NP_001350870.1  armadillo repeat-containing protein 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022337, AC068777
    Consensus CDS
    CCDS87139.1
    UniProtKB/Swiss-Prot
    A8K0L2, B7Z441, B7Z453, D3DNE6, F5GWK4, Q6PIL2, Q8IUR7, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9
    Related
    ENSP00000419413.1, ENST00000469044.6
    Conserved Domains (4) summary
    COG5064
    Location:49 → 212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:374 → 607
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:553 → 583
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:57 → 90
    ARM; armadillo repeat [structural motif]

  5. NM_001363942.1 → NP_001350871.1  armadillo repeat-containing protein 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC022337, AC068777
    Consensus CDS
    CCDS87140.1
    UniProtKB/TrEMBL
    B7Z5P0
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  6. NM_014154.4 → NP_054873.2  armadillo repeat-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_054873.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK289577, BC013424, DC342329, HY004298
    Consensus CDS
    CCDS3098.1
    UniProtKB/TrEMBL
    G5E9V6
    Related
    ENSP00000420440.1, ENST00000471453.5
    Conserved Domains (2) summary
    COG5064
    Location:35 → 198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:43 → 76
    ARM; armadillo repeat [structural motif]

  7. NM_015396.6 → NP_056211.2  armadillo repeat-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_056211.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes multiple additional exons in the coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL096748, BC041699, BQ014283, HY004298
    Consensus CDS
    CCDS54646.1
    UniProtKB/TrEMBL
    B7Z5P0
    Related
    ENSP00000420333.1, ENST00000481646.5
    Conserved Domains (4) summary
    COG5064
    Location:35 → 198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:360 → 593
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:539 → 569
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:43 → 76
    ARM; armadillo repeat [structural motif]

  8. NM_213654.3 → NP_998819.1  armadillo repeat-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_998819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC013424, HY004298
    Consensus CDS
    CCDS3098.1
    UniProtKB/TrEMBL
    G5E9V6
    Related
    ENSP00000351221.2, ENST00000358441.6
    Conserved Domains (2) summary
    COG5064
    Location:35 → 198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:43 → 76
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    138187248..138298389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713565.3 → XP_006713628.1  armadillo repeat-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006713628.1

    UniProtKB/TrEMBL
    B7Z5P0
    Conserved Domains (4) summary
    COG5064
    Location:35 → 198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:360 → 593
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:539 → 569
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:43 → 76
    ARM; armadillo repeat [structural motif]

  2. XM_024453441.2 → XP_024309209.1  armadillo repeat-containing protein 8 isoform X3

    Conserved Domains (4) summary
    COG5369
    Location:329 → 562
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:508 → 538
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:43 → 76
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:8 → 167
    Arm_3; Atypical Arm repeat

  3. XM_011512632.2 → XP_011510934.1  armadillo repeat-containing protein 8 isoform X2

    See identical proteins and their annotated locations for XP_011510934.1

    UniProtKB/TrEMBL
    B7Z5P0
    Related
    ENSP00000417304.1, ENST00000491704.5
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  4. XM_006713566.5 → XP_006713629.1  armadillo repeat-containing protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006713629.1

    UniProtKB/TrEMBL
    B7Z5P0
    Conserved Domains (4) summary
    COG5064
    Location:7 → 170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332 → 565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511 → 541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:15 → 48
    ARM; armadillo repeat [structural motif]

  5. XM_047447900.1 → XP_047303856.1  armadillo repeat-containing protein 8 isoform X4

  6. XM_017006100.3 → XP_016861589.1  armadillo repeat-containing protein 8 isoform X5

  7. XM_047447902.1 → XP_047303858.1  armadillo repeat-containing protein 8 isoform X7

    Related
    ENSP00000418405.1, ENST00000470821.5

  8. XM_047447901.1 → XP_047303857.1  armadillo repeat-containing protein 8 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    140927839..141038955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346018.1 → XP_054201993.1  armadillo repeat-containing protein 8 isoform X1

  2. XM_054346021.1 → XP_054201996.1  armadillo repeat-containing protein 8 isoform X3

  3. XM_054346020.1 → XP_054201995.1  armadillo repeat-containing protein 8 isoform X2

  4. XM_054346019.1 → XP_054201994.1  armadillo repeat-containing protein 8 isoform X2

  5. XM_054346022.1 → XP_054201997.1  armadillo repeat-containing protein 8 isoform X4

  6. XM_054346023.1 → XP_054201998.1  armadillo repeat-containing protein 8 isoform X5

  7. XM_054346025.1 → XP_054202000.1  armadillo repeat-containing protein 8 isoform X7

  8. XM_054346024.1 → XP_054201999.1  armadillo repeat-containing protein 8 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IUR7.2 GenPept UniProtKB/Swiss-Prot:Q8IUR7

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