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ANAPC13 anaphase promoting complex subunit 13 [ Homo sapiens (human) ]

Gene ID: 25847, updated on 5-Mar-2024

Summary

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Official Symbol
ANAPC13provided by HGNC
Official Full Name
anaphase promoting complex subunit 13provided by HGNC
Primary source
HGNC:HGNC:24540
See related
Ensembl:ENSG00000129055 MIM:614484; AllianceGenome:HGNC:24540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWM1; APC13
Summary
This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in thyroid (RPKM 36.9), kidney (RPKM 32.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ANAPC13 in Genome Data Viewer
Location:
3q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134477704..134486023, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137222876..137231191, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134196546..134204865, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134124670-134125376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134126084-134126789 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:134145749-134146948 Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:134181408-134182134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134183586-134184310 Neighboring gene microRNA 4788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20563 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134205013-134205831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20565 Neighboring gene centrosomal protein 63 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134245816-134246316 Neighboring gene DPPA4 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 9743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134338253-134338753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134361872-134362713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134362971-134363635 Neighboring gene kyphoscoliosis peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Castro A, et al. Oncogene, 2005 Jan 13. PMID 15678131
  2. Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. Holzmann J, et al. J Proteome Res, 2011 Feb 4. PMID 21043528, Free PMC Article
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. Chang L, et al. Nature, 2015 Jun 25. PMID 26083744, Free PMC Article
  4. Molecular mechanism of APC/C activation by mitotic phosphorylation. Zhang S, et al. Nature, 2016 May 12. PMID 27120157, Free PMC Article
  5. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. Yamaguchi M, et al. J Mol Biol, 2015 Apr 24. PMID 25490258, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 20 loci that influence adult height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp566D193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
anaphase-promoting complex subunit 13
Names
cyclosome subunit 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242374.1 → NP_001229303.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_001229303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC010207, AK290761, AV682398, BU627217
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18, Q9Y3V0
    UniProtKB/TrEMBL
    A6NJK6, A8K3Z6, D3DND5
    Related
    ENSP00000421842.1, ENST00000510994.5
    Conserved Domains (1) summary
    pfam05839
    Location:1 → 74
    Apc13p; Apc13p protein

  2. NM_001242375.1 → NP_001229304.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_001229304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC010207, AV682398, BU627217, CN258858
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18, Q9Y3V0
    UniProtKB/TrEMBL
    A6NJK6, A8K3Z6, D3DND5
    Related
    ENSP00000427327.1, ENST00000514612.5
    Conserved Domains (1) summary
    pfam05839
    Location:1 → 74
    Apc13p; Apc13p protein

  3. NM_015391.4 → NP_056206.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_056206.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK026550, BC005398
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18, Q9Y3V0
    UniProtKB/TrEMBL
    A6NJK6, A8K3Z6, D3DND5
    Related
    ENSP00000346987.5, ENST00000354910.10
    Conserved Domains (1) summary
    pfam05839
    Location:1 → 74
    Apc13p; Apc13p protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    134477704..134486023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    137222876..137231191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BS18.1 GenPept UniProtKB/Swiss-Prot:Q9BS18

Gene LinkOut

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