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TMEM184B transmembrane protein 184B [ Homo sapiens (human) ]

Gene ID: 25829, updated on 11-Apr-2024

Summary

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Official Symbol
TMEM184Bprovided by HGNC
Official Full Name
transmembrane protein 184Bprovided by HGNC
Primary source
HGNC:HGNC:1310
See related
Ensembl:ENSG00000198792 AllianceGenome:HGNC:1310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FM08; HS5O6A; C22orf5; HSPC256; SLC51C2
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 20.3), fat (RPKM 18.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38216395..38273010, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38680395..38737356, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38615298..38669016, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38510521-38511423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38518609-38519118 Neighboring gene phospholipase A2 group VI Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38538756-38539256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38559728-38560228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38560229-38560729 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38561911 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38570189 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38572440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18996 Neighboring gene Sharpr-MPRA regulatory region 6169 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38580917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13709 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38600595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13710 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38603571 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607237 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607534 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38608227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38609813-38610394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13712 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:38614213-38615412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38618750-38619250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38620666-38621166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38624990-38625720 Neighboring gene TMEM184B antisense RNA 1 Neighboring gene MAF bZIP transcription factor F Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13713 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38659892-38660392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38667767-38668476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38679509-38680035 Neighboring gene TPTEP2-CSNK1E readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685261-38685970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685971-38686678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38694325-38695524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38706687-38707466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13715 Neighboring gene casein kinase 1 epsilon Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38714878-38715782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38718279-38719070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38720450-38720962 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38720963-38721473 Neighboring gene Sharpr-MPRA regulatory region 8587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38723521-38724032 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38737560-38737744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38740513-38741012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38743105-38744002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13716 Neighboring gene TPTE pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38793649-38794432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13717

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. Larsen EG, et al. Pain, 2022 May 1. PMID 34629389, Free PMC Article
  2. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, et al. J Neurosci, 2016 Apr 27. PMID 27122027, Free PMC Article
  3. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Fukumoto I, et al. Br J Cancer, 2015 Mar 3. PMID 25668004, Free PMC Article
  4. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Lindström S, et al. Nat Commun, 2014 Oct 24. PMID 25342443, Free PMC Article
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data shows that miR-26a and miR-26b were significantly downregulated and their direct target, TMEM184B significantly up-regulated in oral squamous cell carcinoma cells.
    Title: MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.
  2. C22orf5 (FM08) represents a novel gene found during a screening of gene that activate the MAPK pathway.
    Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp586A1024, DKFZp686N1150, DKFZp686F07174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 184B
Names
putative MAPK-activating protein FM08

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195071.1 → NP_001182000.1  transmembrane protein 184B isoform a

    See identical proteins and their annotated locations for NP_001182000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AL020993, AL021977, BQ004586, BX648345
    Consensus CDS
    CCDS13969.2
    UniProtKB/Swiss-Prot
    A8K9D7, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5, Q9Y519
    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Related
    ENSP00000354441.4, ENST00000361684.8
    Conserved Domains (1) summary
    pfam03619
    Location:48 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  2. NM_001195072.2 → NP_001182001.1  transmembrane protein 184B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The predicted protein (isoform b) has a shorter N-terminus when it is compared to isoform a.
    Source sequence(s)
    AK292652, BC012983, BI197128, BQ004586, CR749859
    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Conserved Domains (1) summary
    pfam03619
    Location:1 → 251
    Solute_trans_a; Organic solute transporter Ostalpha

  3. NM_012264.5 → NP_036396.2  transmembrane protein 184B isoform a

    See identical proteins and their annotated locations for NP_036396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the most frequently occurring transcript variant. The resulting protein (isoform a) is the longer protein. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292652, BC012983, BQ004586
    Consensus CDS
    CCDS13969.2
    UniProtKB/Swiss-Prot
    A8K9D7, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5, Q9Y519
    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Related
    ENSP00000355210.3, ENST00000361906.8
    Conserved Domains (1) summary
    pfam03619
    Location:48 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38216395..38273010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441319.1 → XP_047297275.1  transmembrane protein 184B isoform X11

  2. XM_047441316.1 → XP_047297272.1  transmembrane protein 184B isoform X9

  3. XM_017028759.2 → XP_016884248.1  transmembrane protein 184B isoform X5

    UniProtKB/TrEMBL
    A0A0J9YYJ3

  4. XM_011530113.2 → XP_011528415.1  transmembrane protein 184B isoform X4

    See identical proteins and their annotated locations for XP_011528415.1

    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  5. XM_017028756.2 → XP_016884245.1  transmembrane protein 184B isoform X6

    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Related
    ENSP00000488878.1, ENST00000633438.1
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  6. XM_017028755.2 → XP_016884244.1  transmembrane protein 184B isoform X3

  7. XM_017028754.2 → XP_016884243.1  transmembrane protein 184B isoform X1

  8. XM_011530112.3 → XP_011528414.2  transmembrane protein 184B isoform X2

  9. XM_047441320.1 → XP_047297276.1  transmembrane protein 184B isoform X5

  10. XM_011530114.2 → XP_011528416.1  transmembrane protein 184B isoform X4

    See identical proteins and their annotated locations for XP_011528416.1

    UniProtKB/TrEMBL
    A0A0J9YYJ3
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  11. XM_011530115.4 → XP_011528417.1  transmembrane protein 184B isoform X7

    Conserved Domains (1) summary
    pfam03619
    Location:96 → 293
    Solute_trans_a; Organic solute transporter Ostalpha

  12. XM_017028757.2 → XP_016884246.1  transmembrane protein 184B isoform X8

  13. XM_047441315.1 → XP_047297271.1  transmembrane protein 184B isoform X4

  14. XM_047441317.1 → XP_047297273.1  transmembrane protein 184B isoform X10

  15. XM_047441318.1 → XP_047297274.1  transmembrane protein 184B isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38680395..38737356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325503.1 → XP_054181478.1  transmembrane protein 184B isoform X11

  2. XM_054325500.1 → XP_054181475.1  transmembrane protein 184B isoform X9

  3. XM_054325496.1 → XP_054181471.1  transmembrane protein 184B isoform X5

  4. XM_054325497.1 → XP_054181472.1  transmembrane protein 184B isoform X6

  5. XM_054325492.1 → XP_054181467.1  transmembrane protein 184B isoform X3

  6. XM_054325491.1 → XP_054181466.1  transmembrane protein 184B isoform X2

  7. XM_054325504.1 → XP_054181479.1  transmembrane protein 184B isoform X5

  8. XM_054325499.1 → XP_054181474.1  transmembrane protein 184B isoform X8

  9. XM_054325493.1 → XP_054181468.1  transmembrane protein 184B isoform X4

  10. XM_054325490.1 → XP_054181465.1  transmembrane protein 184B isoform X1

  11. XM_054325494.1 → XP_054181469.1  transmembrane protein 184B isoform X4

  12. XM_054325498.1 → XP_054181473.1  transmembrane protein 184B isoform X7

  13. XM_054325495.1 → XP_054181470.1  transmembrane protein 184B isoform X4

  14. XM_054325501.1 → XP_054181476.1  transmembrane protein 184B isoform X10

  15. XM_054325502.1 → XP_054181477.1  transmembrane protein 184B isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y519.2 GenPept UniProtKB/Swiss-Prot:Q9Y519

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