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CCDC197 coiled-coil domain containing 197 [ Homo sapiens (human) ]

Gene ID: 256369, updated on 7-Apr-2024

Summary

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Official Symbol
CCDC197provided by HGNC
Official Full Name
coiled-coil domain containing 197provided by HGNC
Primary source
HGNC:HGNC:19860
See related
Ensembl:ENSG00000175699 AllianceGenome:HGNC:19860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf48; c14_5713; LINC00521
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.2) See more
Orthologs
all
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Genomic context

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See CCDC197 in Genome Data Viewer
Location:
14q32.12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (93987225..94011695)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88214540..88239010)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94463616..94478041)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene FAM181A antisense RNA 1 Neighboring gene family with sequence similarity 181 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94407532-94408032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94408033-94408533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94420244-94421221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94421332-94422038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94422039-94422743 Neighboring gene ankyrin repeat and SOCS box containing 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:94425411-94426610 Neighboring gene microRNA 4506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94428828-94429328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94429329-94429829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94441397-94441968 Neighboring gene uncharacterized LOC107984663 Neighboring gene uncharacterized LOC124903368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94482885-94483384 Neighboring gene Sharpr-MPRA regulatory region 4126 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94518750-94519679 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:94526511-94527710 Neighboring gene DEAD-box helicase 24 Neighboring gene interferon alpha inducible protein 27 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Namciu SJ, et al. Mamm Genome, 2004 Mar. PMID 15014966
  2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33356, DKFZp434O1910

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein CCDC197
Names
coiled-coil domain-containing protein 197
long intergenic non-protein coding RNA 521

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351596.2 → NP_001338525.1  uncharacterized protein CCDC197 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL079302
    Consensus CDS
    CCDS86426.1
    UniProtKB/TrEMBL
    A0A1B0GUF5
    Related
    ENSP00000490086.1, ENST00000636493.2
    Conserved Domains (1) summary
    pfam13863
    Location:18 → 59
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_001411045.1 → NP_001397974.1  uncharacterized protein CCDC197 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL079302
    Consensus CDS
    CCDS91922.1
    UniProtKB/TrEMBL
    A0A1W2PPK9
    Related
    ENSP00000491594.1, ENST00000640978.1

RNA

  1. NR_024182.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA412651, AL079302, BC031252, DB446670
    Related
    ENST00000444118.5

  2. NR_024183.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA412651, AK097741, AL157489

  3. NR_024184.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA412651, AK097741, BC021728
    Related
    ENST00000359253.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    93987225..94011695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431194.1 → XP_047287150.1  uncharacterized protein CCDC197 isoform X1

  2. XM_047431188.1 → XP_047287144.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  3. XM_047431193.1 → XP_047287149.1  uncharacterized protein CCDC197 isoform X4

  4. XM_024449525.2 → XP_024305293.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5
    Conserved Domains (1) summary
    pfam13863
    Location:18 → 59
    DUF4200; Domain of unknown function (DUF4200)

  5. XM_047431185.1 → XP_047287141.1  uncharacterized protein CCDC197 isoform X1

  6. XM_047431183.1 → XP_047287139.1  uncharacterized protein CCDC197 isoform X1

  7. XM_047431191.1 → XP_047287147.1  uncharacterized protein CCDC197 isoform X4

  8. XM_047431186.1 → XP_047287142.1  uncharacterized protein CCDC197 isoform X1

  9. XM_024449524.2 → XP_024305292.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5
    Conserved Domains (1) summary
    pfam13863
    Location:18 → 59
    DUF4200; Domain of unknown function (DUF4200)

  10. XM_047431184.1 → XP_047287140.1  uncharacterized protein CCDC197 isoform X1

  11. XM_047431189.1 → XP_047287145.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  12. XM_047431187.1 → XP_047287143.1  uncharacterized protein CCDC197 isoform X1

  13. XM_047431192.1 → XP_047287148.1  uncharacterized protein CCDC197 isoform X5

  14. XM_047431190.1 → XP_047287146.1  uncharacterized protein CCDC197 isoform X3

  15. XM_047431196.1 → XP_047287152.1  uncharacterized protein CCDC197 isoform X6

  16. XM_047431197.1 → XP_047287153.1  uncharacterized protein CCDC197 isoform X7

RNA

  1. XR_007063999.1 RNA Sequence

  2. XR_007064000.1 RNA Sequence

  3. XR_007064001.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1101787..1126257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328970.1 → XP_054184945.1  uncharacterized protein CCDC197 isoform X1

  2. XM_054328964.1 → XP_054184939.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  3. XM_054328969.1 → XP_054184944.1  uncharacterized protein CCDC197 isoform X4

  4. XM_054328962.1 → XP_054184937.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  5. XM_054328959.1 → XP_054184934.1  uncharacterized protein CCDC197 isoform X1

  6. XM_054328958.1 → XP_054184933.1  uncharacterized protein CCDC197 isoform X1

  7. XM_054328965.1 → XP_054184940.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  8. XM_054328961.1 → XP_054184936.1  uncharacterized protein CCDC197 isoform X1

  9. XM_054328957.1 → XP_054184932.1  uncharacterized protein CCDC197 isoform X1

  10. XM_054328967.1 → XP_054184942.1  uncharacterized protein CCDC197 isoform X4

  11. XM_054328960.1 → XP_054184935.1  uncharacterized protein CCDC197 isoform X1

  12. XM_054328963.1 → XP_054184938.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  13. XM_054328968.1 → XP_054184943.1  uncharacterized protein CCDC197 isoform X5

  14. XM_054328966.1 → XP_054184941.1  uncharacterized protein CCDC197 isoform X3

  15. XM_054328971.1 → XP_054184946.1  uncharacterized protein CCDC197 isoform X6

  16. XM_054328972.1 → XP_054184947.1  uncharacterized protein CCDC197 isoform X7

RNA

  1. XR_008485615.1 RNA Sequence

  2. XR_008485616.1 RNA Sequence

  3. XR_008485617.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    88214540..88239010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375763.1 → XP_054231738.1  uncharacterized protein CCDC197 isoform X1

  2. XM_054375757.1 → XP_054231732.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  3. XM_054375762.1 → XP_054231737.1  uncharacterized protein CCDC197 isoform X4

  4. XM_054375755.1 → XP_054231730.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  5. XM_054375752.1 → XP_054231727.1  uncharacterized protein CCDC197 isoform X1

  6. XM_054375751.1 → XP_054231726.1  uncharacterized protein CCDC197 isoform X1

  7. XM_054375758.1 → XP_054231733.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  8. XM_054375754.1 → XP_054231729.1  uncharacterized protein CCDC197 isoform X1

  9. XM_054375750.1 → XP_054231725.1  uncharacterized protein CCDC197 isoform X1

  10. XM_054375760.1 → XP_054231735.1  uncharacterized protein CCDC197 isoform X4

  11. XM_054375753.1 → XP_054231728.1  uncharacterized protein CCDC197 isoform X1

  12. XM_054375756.1 → XP_054231731.1  uncharacterized protein CCDC197 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GUF5

  13. XM_054375761.1 → XP_054231736.1  uncharacterized protein CCDC197 isoform X5

  14. XM_054375759.1 → XP_054231734.1  uncharacterized protein CCDC197 isoform X3

  15. XM_054375764.1 → XP_054231739.1  uncharacterized protein CCDC197 isoform X6

  16. XM_054375765.1 → XP_054231740.1  uncharacterized protein CCDC197 isoform X7

RNA

  1. XR_008488848.1 RNA Sequence

  2. XR_008488849.1 RNA Sequence

  3. XR_008488850.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152777.2: Suppressed sequence

    Description
    NM_152777.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein, and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCU1.2 GenPept UniProtKB/Swiss-Prot:Q8NCU1

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