U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FUT3 fucosyltransferase 3 (Lewis blood group) [ Homo sapiens (human) ]

Gene ID: 2525, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
FUT3provided by HGNC
Official Full Name
fucosyltransferase 3 (Lewis blood group)provided by HGNC
Primary source
HGNC:HGNC:4014
See related
Ensembl:ENSG00000171124 MIM:111100; AllianceGenome:HGNC:4014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LE; Les; FT3B; CD174; FucT-III
Summary
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
Annotation information
Annotation category: suggests misassembly
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5842888..5857122, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5830330..5844569, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5842899..5857133, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene fucosyltransferase 6 Neighboring gene uncharacterized LOC101928844 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5855126-5855513 Neighboring gene Sharpr-MPRA regulatory region 2774 Neighboring gene Sharpr-MPRA regulatory region 10376 Neighboring gene fucosyltransferase 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5892267-5893073 Neighboring gene MPRA-validated peak3300 silencer Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene Sharpr-MPRA regulatory region 9916

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Correlations of FUT3 gene polymorphisms with colon polyps. Hu X, et al. Cell Cycle, 2022 Jan. PMID 34936845, Free PMC Article
  2. Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3. Soejima M, et al. Vox Sang, 2022 Feb. PMID 34156094
  3. Associations between fucosyltransferase 3 gene polymorphisms and ankylosing spondylitis: A case-control study of an east Chinese population. Jiang G, et al. PLoS One, 2020. PMID 32764781, Free PMC Article
  4. The landscape of host genetic factors involved in immune response to common viral infections. Kachuri L, et al. medRxiv, 2020 Sep 5. PMID 32511533, Free PMC Article
  5. More on 'Association between ABO blood groups and risk of SARS-CoV-2 pneumonia'. O'Sullivan JM, et al. Br J Haematol, 2020 Jul. PMID 32420611, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-kappaB pathway.
    Title: FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.
  2. Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
    Title: Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
  3. Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
    Title: Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
  4. Correlations of FUT3 gene polymorphisms with colon polyps.
    Title: Correlations of FUT3 gene polymorphisms with colon polyps.
  5. Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
    Title: Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
  6. Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
    Title: Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
  7. Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
    Title: Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
  8. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
    Title: FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
  9. High FUT3 expression is a marker of lower overall survival of breast cancer patients.
    Title: High FUT3 expression is a marker of lower overall survival of breast cancer patients.
  10. Systematic sequence analysis of the FUT3 gene identifies 11 novel alleles in the Sindhi and Punjabi populations from Pakistan.
    Title: Systematic sequence analysis of the FUT3 gene identifies 11 novel alleles in the Sindhi and Punjabi populations from Pakistan.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Blood group, lewis system
MedGen: C0023595 OMIM: 618983 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
EBI GWAS Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC131739

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity TAS
Traceable Author Statement
more info
  
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
  
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell recognition IC
Inferred by Curator
more info
 PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macromolecule glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
Lewis FT
alpha-(1,3/1,4)-fucosyltransferase
alpha-3-fucosyltransferase FUT3
blood group Lewis alpha-4-fucosyltransferase
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
fucosyltransferase III
galactoside 3(4)-L-fucosyltransferase
NP_000140.1
NP_001091108.3
NP_001091109.3
NP_001091110.3
NP_001361669.1
NP_001369673.1
NP_001369674.1
NP_001369675.1
NP_001369676.1
NP_001369677.1
NP_001369678.1
NP_001369679.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007482.2 RefSeqGene

    Range
    10674..19235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_800

mRNA and Protein(s)

  1. NM_000149.4 → NP_000140.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    See identical proteins and their annotated locations for NP_000140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as minor I, represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000305603.5, ENST00000303225.12
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. NM_001097639.3 → NP_001091108.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as major II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000465804.1, ENST00000589620.6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. NM_001097640.3 → NP_001091109.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as major I, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000468123.1, ENST00000589918.5
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  4. NM_001097641.3 → NP_001091110.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as minor II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000416443.1, ENST00000458379.7
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  5. NM_001374740.1 → NP_001361669.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  6. NM_001382744.1 → NP_001369673.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  7. NM_001382745.1 → NP_001369674.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  8. NM_001382746.1 → NP_001369675.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  9. NM_001382747.1 → NP_001369676.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  10. NM_001382748.2 → NP_001369677.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  11. NM_001382749.2 → NP_001369678.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  12. NM_001382750.2 → NP_001369679.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    5842888..5857122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791810.1 Reference GRCh38.p14 PATCHES

    Range
    16467..30706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    5830330..5844569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21217.2 GenPept UniProtKB/Swiss-Prot:P21217

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous