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KIF4A kinesin family member 4A [ Homo sapiens (human) ]

Gene ID: 24137, updated on 7-Apr-2024

Summary

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Official Symbol
KIF4Aprovided by HGNC
Official Full Name
kinesin family member 4Aprovided by HGNC
Primary source
HGNC:HGNC:13339
See related
Ensembl:ENSG00000090889 MIM:300521; AllianceGenome:HGNC:13339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF4; TMDI; KIF4G1; MRX100; XLID100
Summary
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Expression
Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
Xq13.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70290104..70420886)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68723423..68854206)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69509954..69640736)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20889 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11 Neighboring gene TRAPPC2L pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69622427-69622649 Neighboring gene RNY4 pseudogene 23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69642130-69643118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69643119-69644107 Neighboring gene uncharacterized LOC105373244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69655249-69655749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69664203-69664989 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene discs large MAGUK scaffold protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells. Zhang C, et al. Cancer Med, 2023 Jun. PMID 37039264, Free PMC Article
  2. Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients. Wu J, et al. Curr Med Sci, 2022 Dec. PMID 36260268
  3. KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of P21 in lung cancer cells. Zhang D, et al. Chem Biol Drug Des, 2023 May. PMID 36217900
  4. Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response. Zhang R, et al. Acta Biochim Biophys Sin (Shanghai), 2022 May 25. PMID 35882623, Free PMC Article
  5. The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro. Gad SA, et al. PLoS Pathog, 2022 Mar. PMID 35312737, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
    Title: Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
  2. KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of P21 in lung cancer cells.
    Title: KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of P21 in lung cancer cells.
  3. DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.
    Title: DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.
  4. KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
    Title: KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
  5. Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients.
    Title: Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients.
  6. Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
    Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
  7. Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.
    Title: Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.
  8. KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment.
    Title: KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment.
  9. The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.
    Title: The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.
  10. EZH2 suppresses insulinoma development by epigenetically reducing KIF4A expression via H3K27me3 modification.
    Title: EZH2 suppresses insulinoma development by epigenetically reducing KIF4A expression via H3K27me3 modification.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, X-linked 100
MedGen: C3890167 OMIM: 300923 GeneReviews: Not available
Compare labs
Taurodontism, microdontia, and dens invaginatus
MedGen: C1839235 OMIM: 313490 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed
matrix gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Binding of HIV-1 Matrix to KIF-4 may play a role in HIV-1 Gag polyprotein relocalize from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Matrix is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12530, FLJ12655, FLJ14204, FLJ20631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in spindle microtubule TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
chromosome-associated kinesin KIF4A
Names
chromokinesin KIF4A
chromokinesin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016799.2 RefSeqGene

    Range
    5002..135784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012310.5 → NP_036442.3  chromosome-associated kinesin KIF4A

    See identical proteins and their annotated locations for NP_036442.3

    Status: REVIEWED

    Source sequence(s)
    AL139398, AL357752
    Consensus CDS
    CCDS14401.1
    UniProtKB/Swiss-Prot
    B2R7V5, D3DVU4, O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3
    UniProtKB/TrEMBL
    Q59HG1
    Related
    ENSP00000363524.3, ENST00000374403.4
    Conserved Domains (4) summary
    COG1196
    Location:558 → 918
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:375 → 714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01372
    Location:8 → 337
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:1078 → 1120
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    70290104..70420886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    68723423..68854206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95239.3 GenPept UniProtKB/Swiss-Prot:O95239

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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