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FRA6E fragile site, aphidicolin type, common, fra(6)(q26) [ Homo sapiens (human) ]

Gene ID: 2405, updated on 24-Mar-2019

Summary

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Official Symbol
FRA6Eprovided by HGNC
Official Full Name
fragile site, aphidicolin type, common, fra(6)(q26)provided by HGNC
Primary source
HGNC:HGNC:3916
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
not in current annotation release
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Genomic context

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Location:
6q26

Bibliography

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Related articles in PubMed

  1. Replication dynamics at common fragile site FRA6E. Palumbo E, et al. Chromosoma, 2010 Dec. PMID 20585795
  2. Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Denison SR, et al. Genes Chromosomes Cancer, 2003 Sep. PMID 12874785
  3. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Cesari R, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12719539, Free PMC Article
  4. Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer. Letessier A, et al. Oncogene, 2007 Jan 11. PMID 16819513

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. At FRA6E the replication process is not impaired per se, but chromosome breakages occur at an early/late replication transition zone.
    Title: Replication dynamics at common fragile site FRA6E.
  2. Chromosome break at FRA6E is associated with breast cancer
    Title: Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.
  3. FRA6E shares many similarities with FRA3B (3p14.2) and FRA16D (16q23.2) in representing a large region of genomic instability and containing an extremely large gene that may play a role in the development of ovarian and many other cancers.
    Title: Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer.
Submit: New GeneRIF Correction

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