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KAT6B lysine acetyltransferase 6B [ Homo sapiens (human) ]

Gene ID: 23522, updated on 11-Apr-2024

Summary

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Official Symbol
KAT6Bprovided by HGNC
Official Full Name
lysine acetyltransferase 6Bprovided by HGNC
Primary source
HGNC:HGNC:17582
See related
Ensembl:ENSG00000156650 MIM:605880; AllianceGenome:HGNC:17582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
qkf; MORF; MOZ2; GTPTS; MYST4; ZC2HC6B; querkopf
Summary
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in ovary (RPKM 9.9), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q22.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (74824936..75032624)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75698186..75906154)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76585013..76792382)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3598 Neighboring gene VISTA enhancer hs1500 Neighboring gene family with sequence similarity 32 member C, pseudogene Neighboring gene MPRA-validated peak1017 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76555535-76556121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76584665-76585436 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76585437-76586208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2504 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76615828-76616038 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76630209-76630443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3601 Neighboring gene MPRA-validated peak1019 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3602 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76776654-76776821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76789883-76790382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3604 Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms. Yabumoto M, et al. Mol Genet Genomic Med, 2021 Oct. PMID 34519438, Free PMC Article
  2. Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma. Jiang J, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 34464167, Free PMC Article
  3. Novel Approach of Mandibular Distraction to Avoid Tracheostomy in KAT6B-related Gene Disorders. Bacos J, et al. J Craniofac Surg, 2020 Nov-Dec. PMID 33136874
  4. High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis. Wu Y, et al. J Transl Med, 2020 May 24. PMID 32448279, Free PMC Article
  5. Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants. Zhang LX, et al. Genet Med, 2020 Aug. PMID 32424177, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical heterogeneity of polish patients with KAT6B-related disorder.
    Title: Clinical heterogeneity of polish patients with KAT6B-related disorder.
  2. Clinical features and underlying mechanisms of KAT6B disease in a Chinese boy.
    Title: Clinical features and underlying mechanisms of KAT6B disease in a Chinese boy.
  3. Novel variant in the KAT6B gene associated with Say Barber Biesecker Young Simpson.
    Title: Novel variant in the KAT6B gene associated with Say Barber Biesecker Young Simpson.
  4. MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
    Title: MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
  5. XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-kappaB signalling.
    Title: XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signalling.
  6. Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.
    Title: Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.
  7. Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms.
    Title: Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms.
  8. Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
    Title: Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
  9. High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.
    Title: High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.
  10. CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis.
    Title: CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-04-25)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2018-04-25)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90335, KIAA0383, DKFZp313G1618

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase KAT6B
Names
K(lysine) acetyltransferase 6B
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
MOZ-related factor
MYST histone acetyltransferase (monocytic leukemia) 4
MYST-4
histone acetyltransferase MORF
histone acetyltransferase MOZ2
histone acetyltransferase MYST4
monocytic leukemia zinc finger protein-related factor
NP_001243397.1
NP_001243398.1
NP_001357061.1
NP_001357062.1
NP_001357063.1
NP_001357064.1
NP_001357065.1
NP_001357066.1
NP_001357067.1
NP_001357068.1
NP_001357069.1
NP_001357070.1
NP_001357071.1
NP_001357072.1
NP_001357073.1
NP_036462.2
XP_005269721.1
XP_016871493.1
XP_047280867.1
XP_047280868.1
XP_047280869.1
XP_047280871.1
XP_047280872.1
XP_047280873.1
XP_047280874.1
XP_047280875.1
XP_047280876.1
XP_047280877.1
XP_047280878.1
XP_047280879.1
XP_047280880.1
XP_047280882.1
XP_047280883.1
XP_047280884.1
XP_047280885.1
XP_054187567.1
XP_054187568.1
XP_054187569.1
XP_054187570.1
XP_054187571.1
XP_054187572.1
XP_054187573.1
XP_054187574.1
XP_054187575.1
XP_054187576.1
XP_054187577.1
XP_054187578.1
XP_054187579.1
XP_054187580.1
XP_054187581.1
XP_054187582.1
XP_054187583.1
XP_054187584.1
XP_054187585.1
XP_054221326.1
XP_054221327.1
XP_054221328.1
XP_054221329.1
XP_054221330.1
XP_054221331.1
XP_054221332.1
XP_054221333.1
XP_054221334.1
XP_054221335.1
XP_054221336.1
XP_054221337.1
XP_054221338.1
XP_054221339.1
XP_054221340.1
XP_054221341.1
XP_054221342.1
XP_054221343.1
XP_054221344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032048.1 RefSeqGene

    Range
    5188..211212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256468.2 → NP_001243397.1  histone acetyltransferase KAT6B isoform 2

    See identical proteins and their annotated locations for NP_001243397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AC018511, AF119230, AF217500, BC150618, DA488537
    Consensus CDS
    CCDS58085.1
    UniProtKB/TrEMBL
    A7E2B6
    Related
    ENSP00000361809.2, ENST00000372724.6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:538 → 806
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:212 → 270
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    pfam05466
    Location:1252 → 1381
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  2. NM_001256469.2 → NP_001243398.1  histone acetyltransferase KAT6B isoform 3

    See identical proteins and their annotated locations for NP_001243398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3 and 11-14 all encode the same isoform (3).
    Source sequence(s)
    AC018511, AF113514, AF217500, BC150618, DA488537
    Consensus CDS
    CCDS58084.1
    UniProtKB/TrEMBL
    A7E2B6
    Related
    ENSP00000497048.1, ENST00000648892.1
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 697
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    NF033845
    Location:1203 → 1459
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  3. NM_001370132.1 → NP_001357061.1  histone acetyltransferase KAT6B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC018511, AC063962
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 643
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1089 → 1218
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  4. NM_001370133.1 → NP_001357062.1  histone acetyltransferase KAT6B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC018511, AC063962
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (4) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    cd15618
    Location:212 → 269
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:872 → 1001
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam01853
    Location:283 → 390
    MOZ_SAS; MOZ/SAS family

  5. NM_001370134.1 → NP_001357063.1  histone acetyltransferase KAT6B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC018511, AC063962
    Conserved Domains (2) summary
    PLN00104
    Location:80 → 294
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam05466
    Location:740 → 869
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  6. NM_001370135.1 → NP_001357064.1  histone acetyltransferase KAT6B isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC018511, AC063962
    Conserved Domains (2) summary
    pfam05466
    Location:654 → 783
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam01853
    Location:65 → 172
    MOZ_SAS; MOZ/SAS family

  7. NM_001370136.1 → NP_001357065.1  histone acetyltransferase KAT6B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 9, encodes isoform 1.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS7345.1
    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
    UniProtKB/TrEMBL
    B2RWN8
    Related
    ENSP00000497166.1, ENST00000649463.1
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:212 → 269
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1435 → 1564
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  8. NM_001370137.1 → NP_001357066.1  histone acetyltransferase KAT6B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1 and 8, encodes isoform 1.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS7345.1
    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
    UniProtKB/TrEMBL
    B2RWN8
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:212 → 269
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1435 → 1564
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  9. NM_001370138.1 → NP_001357067.1  histone acetyltransferase KAT6B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS58085.1
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:538 → 806
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:212 → 270
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    pfam05466
    Location:1252 → 1381
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  10. NM_001370139.1 → NP_001357068.1  histone acetyltransferase KAT6B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 3 and 12-14, encodes isoform 3.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS58084.1
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 697
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    NF033845
    Location:1203 → 1459
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  11. NM_001370140.1 → NP_001357069.1  histone acetyltransferase KAT6B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3, 11, 13, and 14, encodes isoform 3.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS58084.1
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 697
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    NF033845
    Location:1203 → 1459
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  12. NM_001370141.1 → NP_001357070.1  histone acetyltransferase KAT6B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3, 11, 12, and 14, encodes isoform 3.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS58084.1
    UniProtKB/TrEMBL
    A7E2B6
    Related
    ENSP00000361810.1, ENST00000372725.6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 697
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    NF033845
    Location:1203 → 1459
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  13. NM_001370142.1 → NP_001357071.1  histone acetyltransferase KAT6B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3 and 11-13, encodes isoform 3.
    Source sequence(s)
    AC018511, AC063962
    Consensus CDS
    CCDS58084.1
    UniProtKB/TrEMBL
    A7E2B6
    Related
    ENSP00000361799.1, ENST00000372714.6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:429 → 697
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    NF033845
    Location:1203 → 1459
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  14. NM_001370143.1 → NP_001357072.1  histone acetyltransferase KAT6B isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 8.
    Source sequence(s)
    AC018511, AC063962
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:366 → 634
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 309
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1080 → 1209
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  15. NM_001370144.1 → NP_001357073.1  histone acetyltransferase KAT6B isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 8.
    Source sequence(s)
    AC018511, AC063962
    UniProtKB/TrEMBL
    A7E2B6
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:366 → 634
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 309
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1080 → 1209
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl22851
    Location:212 → 270
    PHD_SF; PHD finger superfamily

  16. NM_012330.4 → NP_036462.2  histone acetyltransferase KAT6B isoform 1

    See identical proteins and their annotated locations for NP_036462.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 8, and 9 all encode the same isoform (1).
    Source sequence(s)
    AC018511, AF217500, BC014143, BC150618, DA488537
    Consensus CDS
    CCDS7345.1
    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
    UniProtKB/TrEMBL
    B2RWN8
    Related
    ENSP00000287239.4, ENST00000287239.10
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:212 → 269
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1435 → 1564
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    74824936..75032624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424912.1 → XP_047280868.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  2. XM_047424919.1 → XP_047280875.1  histone acetyltransferase KAT6B isoform X3

  3. XM_047424927.1 → XP_047280883.1  histone acetyltransferase KAT6B isoform X5

  4. XM_005269664.3 → XP_005269721.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_005269721.1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
    UniProtKB/TrEMBL
    B2RWN8
    Related
    ENSP00000497841.1, ENST00000648725.1
    Conserved Domains (5) summary
    smart00526
    Location:113 → 167
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:271 → 317
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:212 → 269
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam05466
    Location:1435 → 1564
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

  5. XM_047424913.1 → XP_047280869.1  histone acetyltransferase KAT6B isoform X2

  6. XM_047424916.1 → XP_047280872.1  histone acetyltransferase KAT6B isoform X3

  7. XM_047424923.1 → XP_047280879.1  histone acetyltransferase KAT6B isoform X5

  8. XM_047424929.1 → XP_047280885.1  histone acetyltransferase KAT6B isoform X6

  9. XM_047424911.1 → XP_047280867.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  10. XM_047424918.1 → XP_047280874.1  histone acetyltransferase KAT6B isoform X3

  11. XM_047424922.1 → XP_047280878.1  histone acetyltransferase KAT6B isoform X4

  12. XM_047424924.1 → XP_047280880.1  histone acetyltransferase KAT6B isoform X5

  13. XM_017016004.3 → XP_016871493.1  histone acetyltransferase KAT6B isoform X2

    UniProtKB/TrEMBL
    B2RWN8

  14. XM_047424920.1 → XP_047280876.1  histone acetyltransferase KAT6B isoform X4

  15. XM_047424928.1 → XP_047280884.1  histone acetyltransferase KAT6B isoform X6

  16. XM_047424917.1 → XP_047280873.1  histone acetyltransferase KAT6B isoform X3

  17. XM_047424926.1 → XP_047280882.1  histone acetyltransferase KAT6B isoform X5

  18. XM_047424915.1 → XP_047280871.1  histone acetyltransferase KAT6B isoform X2

  19. XM_047424921.1 → XP_047280877.1  histone acetyltransferase KAT6B isoform X4

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646202.1 Reference GRCh38.p14 PATCHES

    Range
    29342..237300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331598.1 → XP_054187573.1  histone acetyltransferase KAT6B isoform X3

  2. XM_054331592.1 → XP_054187567.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  3. XM_054331596.1 → XP_054187571.1  histone acetyltransferase KAT6B isoform X2

  4. XM_054331605.1 → XP_054187580.1  histone acetyltransferase KAT6B isoform X5

  5. XM_054331610.1 → XP_054187585.1  histone acetyltransferase KAT6B isoform X6

  6. XM_054331593.1 → XP_054187568.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  7. XM_054331600.1 → XP_054187575.1  histone acetyltransferase KAT6B isoform X3

  8. XM_054331608.1 → XP_054187583.1  histone acetyltransferase KAT6B isoform X5

  9. XM_054331594.1 → XP_054187569.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  10. XM_054331601.1 → XP_054187576.1  histone acetyltransferase KAT6B isoform X3

  11. XM_054331604.1 → XP_054187579.1  histone acetyltransferase KAT6B isoform X4

  12. XM_054331606.1 → XP_054187581.1  histone acetyltransferase KAT6B isoform X5

  13. XM_054331595.1 → XP_054187570.1  histone acetyltransferase KAT6B isoform X2

  14. XM_054331602.1 → XP_054187577.1  histone acetyltransferase KAT6B isoform X4

  15. XM_054331609.1 → XP_054187584.1  histone acetyltransferase KAT6B isoform X6

  16. XM_054331599.1 → XP_054187574.1  histone acetyltransferase KAT6B isoform X3

  17. XM_054331607.1 → XP_054187582.1  histone acetyltransferase KAT6B isoform X5

  18. XM_054331597.1 → XP_054187572.1  histone acetyltransferase KAT6B isoform X2

  19. XM_054331603.1 → XP_054187578.1  histone acetyltransferase KAT6B isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    75698186..75906154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365357.1 → XP_054221332.1  histone acetyltransferase KAT6B isoform X3

  2. XM_054365351.1 → XP_054221326.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  3. XM_054365355.1 → XP_054221330.1  histone acetyltransferase KAT6B isoform X2

  4. XM_054365364.1 → XP_054221339.1  histone acetyltransferase KAT6B isoform X5

  5. XM_054365369.1 → XP_054221344.1  histone acetyltransferase KAT6B isoform X6

  6. XM_054365352.1 → XP_054221327.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  7. XM_054365359.1 → XP_054221334.1  histone acetyltransferase KAT6B isoform X3

  8. XM_054365367.1 → XP_054221342.1  histone acetyltransferase KAT6B isoform X5

  9. XM_054365353.1 → XP_054221328.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/Swiss-Prot
    O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

  10. XM_054365360.1 → XP_054221335.1  histone acetyltransferase KAT6B isoform X3

  11. XM_054365363.1 → XP_054221338.1  histone acetyltransferase KAT6B isoform X4

  12. XM_054365365.1 → XP_054221340.1  histone acetyltransferase KAT6B isoform X5

  13. XM_054365354.1 → XP_054221329.1  histone acetyltransferase KAT6B isoform X2

  14. XM_054365361.1 → XP_054221336.1  histone acetyltransferase KAT6B isoform X4

  15. XM_054365368.1 → XP_054221343.1  histone acetyltransferase KAT6B isoform X6

  16. XM_054365358.1 → XP_054221333.1  histone acetyltransferase KAT6B isoform X3

  17. XM_054365366.1 → XP_054221341.1  histone acetyltransferase KAT6B isoform X5

  18. XM_054365356.1 → XP_054221331.1  histone acetyltransferase KAT6B isoform X2

  19. XM_054365362.1 → XP_054221337.1  histone acetyltransferase KAT6B isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WYB5.3 GenPept UniProtKB/Swiss-Prot:Q8WYB5

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