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SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 [ Homo sapiens (human) ]

Gene ID: 23380, updated on 3-Apr-2024

Summary

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Official Symbol
SRGAP2provided by HGNC
Official Full Name
SLIT-ROBO Rho GTPase activating protein 2provided by HGNC
Primary source
HGNC:HGNC:19751
See related
Ensembl:ENSG00000266028 MIM:606524; AllianceGenome:HGNC:19751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FNBP2; SRGAP3; SRGAP2A; ARHGAP34
Summary
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in skin (RPKM 12.4), spleen (RPKM 10.1) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1q32.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206203541..206464436)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205467727..205728612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206516197..206637776)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372869 Neighboring gene AVPR1B divergent transcript Neighboring gene uncharacterized LOC105372873 Neighboring gene ribosomal protein L22 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:206137267-206137987 Neighboring gene family with sequence similarity 72 member A Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:206105690-206106456 Neighboring gene Sharpr-MPRA regulatory region 15698 duplicate 3 Neighboring gene Sharpr-MPRA regulatory region 356 duplicate 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206553913-206554820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206628023-206628694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206640325-206641190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206641191-206642054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206642729-206643366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2401 Neighboring gene microRNA 6769b Neighboring gene IKBKE antisense RNA 1 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer. Li C, et al. Theranostics, 2023. PMID 36593959, Free PMC Article
  2. SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity. Tang Y, et al. Hum Cell, 2022 Nov. PMID 36059022
  3. The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits. Miao L, et al. Sci Rep, 2017 Sep 14. PMID 28912560, Free PMC Article
  4. Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. Sporny M, et al. Acta Crystallogr D Struct Biol, 2016 Dec 1. PMID 27917825
  5. Rapid and accurate large-scale genotyping of duplicated genes and discovery of interlocus gene conversions. Nuttle X, et al. Nat Methods, 2013 Sep. PMID 23892896, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer.
    Title: Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer.
  2. Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
    Title: Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
  3. SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity.
    Title: SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity.
  4. Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.
    Title: Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.
  5. These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels.
    Title: The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits.
  6. Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.
    Title: Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
  7. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.
    Title: Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function.
  8. The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.
    Title: Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain.
  9. human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance
    Title: SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.
  10. This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.
    Title: The role of human-specific gene duplications during brain development and evolution.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33003, FLJ42565, KIAA0456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendritic spine development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inhibitory synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lamellipodium assembly involved in ameboidal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SLIT-ROBO Rho GTPase-activating protein 2
Names
SLIT-ROBO GAP2
formin-binding protein 2
rho GTPase-activating protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033804.1 RefSeqGene

    Range
    2869..263764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170637.4 → NP_001164108.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform c

    See identical proteins and their annotated locations for NP_001164108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB007925, AC244034, AC244035, AK294060, BC063527, BC144343, DA110905
    Consensus CDS
    CCDS76262.1
    UniProtKB/TrEMBL
    B7ZM87, Q5VZB5
    Related
    ENSP00000485517.1, ENST00000624873.3
    Conserved Domains (4) summary
    cd07682
    Location:26 → 288
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    PHA03269
    Location:962 → 1064
    PHA03269; envelope glycoprotein C; Provisional
    cd11955
    Location:731 → 783
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:486 → 673
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  2. NM_001300952.2 → NP_001287881.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform d

    See identical proteins and their annotated locations for NP_001287881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and differs in the 3' exon structure, result in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC244023, AC244035, AK057565, AK295845, BC041635, CA447513, DA110905
    Consensus CDS
    CCDS76261.1
    UniProtKB/TrEMBL
    A0A075B7B5, B7Z3G4
    Related
    ENSP00000473954.1, ENST00000605610.5
    Conserved Domains (3) summary
    cd11955
    Location:731 → 783
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:486 → 673
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26 → 288
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001377444.1 → NP_001364373.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC244023, AC244034, AC244035
    UniProtKB/TrEMBL
    A0A1S5UZH8, B7Z3G4
    Conserved Domains (3) summary
    cd11955
    Location:732 → 784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487 → 674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26 → 289
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_001377445.1 → NP_001364374.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC244023, AC244034, AC244035
    UniProtKB/TrEMBL
    B7Z3G4
    Conserved Domains (3) summary
    cd11955
    Location:732 → 784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487 → 674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26 → 289
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. NM_001377446.1 → NP_001364375.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC244023, AC244034, AC244035
    UniProtKB/TrEMBL
    B7Z3G4
    Conserved Domains (3) summary
    cd11955
    Location:731 → 783
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:486 → 673
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26 → 288
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. NM_001377447.1 → NP_001364376.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC244023, AC244034, AC244035
    UniProtKB/TrEMBL
    B7Z3G4
    Conserved Domains (3) summary
    cd11955
    Location:732 → 784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487 → 674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26 → 289
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. NM_015326.5 → NP_056141.2  SLIT-ROBO Rho GTPase-activating protein 2 isoform a

    See identical proteins and their annotated locations for NP_056141.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB007925, AC244034, AC244035, AK294060, BC063527, DA110905
    Consensus CDS
    CCDS73017.1
    UniProtKB/Swiss-Prot
    A2RUF3, O75044
    UniProtKB/TrEMBL
    Q5VZB5
    Related
    ENSP00000459615.2, ENST00000573034.8
    Conserved Domains (4) summary
    cd07682
    Location:26 → 289
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    PHA03269
    Location:963 → 1065
    PHA03269; envelope glycoprotein C; Provisional
    cd11955
    Location:732 → 784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487 → 674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206203541..206464436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509354.3 → XP_011507656.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    Q5VZB5
    Conserved Domains (4) summary
    cd07682
    Location:26 → 289
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    cd11955
    Location:732 → 784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487 → 674
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam03867
    Location:953 → 1077
    FTZ; Fushi tarazu (FTZ), N-terminal region

  2. XM_011509355.3 → XP_011507657.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    Q5VZB5
    Conserved Domains (4) summary
    cd07682
    Location:26 → 288
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    cd11955
    Location:731 → 783
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:486 → 673
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam03867
    Location:952 → 1076
    FTZ; Fushi tarazu (FTZ), N-terminal region

  3. XM_047416530.1 → XP_047272486.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X4

  4. XM_047416531.1 → XP_047272487.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X5

  5. XM_047416533.1 → XP_047272489.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

  6. XM_024446014.2 → XP_024301782.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    Q5VZB5
    Conserved Domains (4) summary
    cd11955
    Location:701 → 753
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:456 → 643
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:1 → 258
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28111
    Location:945 → 1047
    Marek_A; Marek's disease glycoprotein A

  7. XM_024446015.2 → XP_024301783.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

    UniProtKB/TrEMBL
    Q5VZB5
    Conserved Domains (4) summary
    cd11955
    Location:701 → 753
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:456 → 643
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:1 → 258
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl28111
    Location:945 → 1047
    Marek_A; Marek's disease glycoprotein A

  8. XM_047416534.1 → XP_047272490.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X7

  9. XM_047416532.1 → XP_047272488.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

  10. XM_047416535.1 → XP_047272491.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X8

  11. XM_047416536.1 → XP_047272492.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X9

    Related
    ENSP00000397990.3, ENST00000419187.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205467727..205728612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335616.1 → XP_054191591.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

  2. XM_054335617.1 → XP_054191592.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X2

  3. XM_054335620.1 → XP_054191595.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X4

  4. XM_054335621.1 → XP_054191596.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X5

  5. XM_054335623.1 → XP_054191598.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

  6. XM_054335618.1 → XP_054191593.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

  7. XM_054335619.1 → XP_054191594.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

  8. XM_054335625.1 → XP_054191600.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X7

  9. XM_054335622.1 → XP_054191597.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

  10. XM_054335626.1 → XP_054191601.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X8

  11. XM_054335627.1 → XP_054191602.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X9

  12. XM_054335624.1 → XP_054191599.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042758.1: Suppressed sequence

    Description
    NM_001042758.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75044.3 GenPept UniProtKB/Swiss-Prot:O75044

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