U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ICOSLG inducible T cell costimulator ligand [ Homo sapiens (human) ]

Gene ID: 23308, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ICOSLGprovided by HGNC
Official Full Name
inducible T cell costimulator ligandprovided by HGNC
Primary source
HGNC:HGNC:17087
See related
Ensembl:ENSG00000160223 MIM:605717; AllianceGenome:HGNC:17087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Summary
Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
21q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44216981..44240943, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42571002..42595008, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45642874..45660826, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45595498-45596144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45596145-45596790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45600775-45601276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45601277-45601776 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45616066-45616566 to GRCh37_chr21:45616069-45616569 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45616946-45617124 Neighboring gene uncharacterized LOC105372832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45621734-45622497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45622498-45623260 Neighboring gene uncharacterized LOC102725065 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:45626388-45627587 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG regulatory elements GRCh37_chr21:45627759-45628259 and GRCh37_chr21:45627787-45628287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45628433-45629348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45633361-45633860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45642723-45643224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45643225-45643724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45645682-45646182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45646183-45646683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45659303-45660081 Neighboring gene CRISPRi-FlowFISH-validated ICOSLG and IFNGR2 regulatory element GRCh37_chr21:45660637-45661636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45662586-45663124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45667417-45668358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669258-45669773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45669774-45670290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45670291-45670805 Neighboring gene DNMT3L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45676001-45676989 Neighboring gene DNA methyltransferase 3 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:45677884-45678384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45681495-45682054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45685919-45686548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45686549-45687178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45691192-45691798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18564 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:45702827-45703430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45703431-45704032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704033-45704636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45704637-45705238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18567 Neighboring gene autoimmune regulator

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity. Zhang G, et al. Biomed Res Int, 2020. PMID 31998801, Free PMC Article
  2. Loss of human ICOSL results in combined immunodeficiency. Roussel L, et al. J Exp Med, 2018 Dec 3. PMID 30498080, Free PMC Article
  3. Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells. Han Y, et al. Front Immunol, 2018. PMID 30319662, Free PMC Article
  4. Expression of B7-H2 on CD8(+) T cells in colorectal cancer microenvironment and its clinical significance. Cao Y, et al. Int Immunopharmacol, 2018 Mar. PMID 29414642
  5. Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele. Hedl M, et al. Immunity, 2014 May 15. PMID 24837102, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma.
    Title: Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma.
  2. ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells.
    Title: ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells.
  3. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
    Title: Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
  4. Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
    Title: Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
  5. Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
    Title: Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
  6. Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-alpha-B7-H2-dependent pathway in human gastric cancer.
    Title: Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-α-B7-H2-dependent pathway in human gastric cancer.
  7. Dysregulated NF-kappaB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
    Title: Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
  8. [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
    Title: [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
  9. Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.
    Title: Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.
  10. The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity.
    Title: The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in hyperosmotic response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of activated T cell proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ICOS ligand
Names
B7 homolog 2
B7 homologue 2
B7-like protein Gl50
B7-related protein 1
transmembrane protein B7-H2 ICOS ligand

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283050.2 → NP_001269979.1  ICOS ligand isoform b precursor

    See identical proteins and their annotated locations for NP_001269979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
    Source sequence(s)
    AA781960, AF199028, DC365972
    Consensus CDS
    CCDS63379.1
    UniProtKB/TrEMBL
    A0A8V8TQ42
    Related
    ENSP00000339477.4, ENST00000344330.9
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 225
    Ig; Immunoglobulin domain

  2. NM_001283051.2 → NP_001269980.1  ICOS ligand isoform c precursor

    See identical proteins and their annotated locations for NP_001269980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK090492, AP001058, BQ005303
    Consensus CDS
    CCDS63377.1
    UniProtKB/Swiss-Prot
    O75144
    Related
    ENSP00000383228.3, ENST00000400377.4
    Conserved Domains (1) summary
    cl11960
    Location:36 → 108
    Ig; Immunoglobulin domain

  3. NM_001283052.2 → NP_001269981.1  ICOS ligand isoform d

    See identical proteins and their annotated locations for NP_001269981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK294031, AP001058, BQ005303
    Consensus CDS
    CCDS93102.1
    UniProtKB/TrEMBL
    B7Z1W8, B7ZA28, B7ZA61
    Related
    ENSP00000514960.1, ENST00000700358.1
    Conserved Domains (1) summary
    cl11960
    Location:68 → 140
    Ig; Immunoglobulin domain

  4. NM_001365759.2 → NP_001352688.1  ICOS ligand isoform e

    Status: VALIDATED

    Source sequence(s)
    AP001058, AP001059
    UniProtKB/TrEMBL
    A0A8V8TQ42
    Conserved Domains (1) summary
    cl11960
    Location:2 → 104
    Ig; Immunoglobulin domain

  5. NM_001395918.1 → NP_001382847.1  ICOS ligand isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AP001058, AP001059
    Consensus CDS
    CCDS93104.1
    UniProtKB/TrEMBL
    A0A8V8TQ42, A0A8V8TQV9
    Related
    ENSP00000514957.1, ENST00000700355.1
    Conserved Domains (3) summary
    cd00096
    Location:154 → 162
    Ig; Ig strand B [structural motif]
    cd20935
    Location:23 → 135
    IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
    cl11960
    Location:149 → 224
    Ig; Immunoglobulin domain

  6. NM_015259.6 → NP_056074.1  ICOS ligand isoform a precursor

    See identical proteins and their annotated locations for NP_056074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK314369, AP001058, BQ005303
    Consensus CDS
    CCDS42952.1
    UniProtKB/Swiss-Prot
    A8MUZ1, O75144, Q9HD18, Q9NRQ1
    UniProtKB/TrEMBL
    A0A8V8TQ42, A0N0L8
    Related
    ENSP00000384432.3, ENST00000407780.8
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 212
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44216981..44240943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529516.4 → XP_011527818.1  ICOS ligand isoform X3

    See identical proteins and their annotated locations for XP_011527818.1

    Conserved Domains (1) summary
    cl11960
    Location:2 → 104
    Ig; Immunoglobulin domain

  2. XM_011529514.4 → XP_011527816.1  ICOS ligand isoform X1

    See identical proteins and their annotated locations for XP_011527816.1

    UniProtKB/TrEMBL
    A0A2R8Y5W7
    Related
    ENSP00000494882.2, ENST00000643466.2
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 225
    Ig; Immunoglobulin domain

  3. XM_047440729.1 → XP_047296685.1  ICOS ligand isoform X2

  4. XM_047440730.1 → XP_047296686.1  ICOS ligand isoform X3

  5. XM_047440732.1 → XP_047296688.1  ICOS ligand isoform X5

  6. XM_047440731.1 → XP_047296687.1  ICOS ligand isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42571002..42595008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324408.1 → XP_054180383.1  ICOS ligand isoform X3

  2. XM_054324405.1 → XP_054180380.1  ICOS ligand isoform X1

  3. XM_054324406.1 → XP_054180381.1  ICOS ligand isoform X2

  4. XM_054324407.1 → XP_054180382.1  ICOS ligand isoform X3

  5. XM_054324411.1 → XP_054180386.1  ICOS ligand isoform X5

  6. XM_054324412.1 → XP_054180387.1  ICOS ligand isoform X5

  7. XM_054324410.1 → XP_054180385.1  ICOS ligand isoform X6

  8. XM_054324409.1 → XP_054180384.1  ICOS ligand isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75144.2 GenPept UniProtKB/Swiss-Prot:O75144

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous