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FKBP15 FKBP prolyl isomerase family member 15 [ Homo sapiens (human) ]

Gene ID: 23307, updated on 3-Apr-2024

Summary

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Official Symbol
FKBP15provided by HGNC
Official Full Name
FKBP prolyl isomerase family member 15provided by HGNC
Primary source
HGNC:HGNC:23397
See related
Ensembl:ENSG00000119321 MIM:617398; AllianceGenome:HGNC:23397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP133; PPP1R76; KIAA0674
Summary
Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis and protein peptidyl-prolyl isomerization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 13.2), appendix (RPKM 13.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FKBP15 in Genome Data Viewer
Location:
9q32
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113161006..113221277, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125359842..125420103, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115923286..115983557, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 225 member B Neighboring gene family with sequence similarity 225 member A Neighboring gene Sharpr-MPRA regulatory region 7760 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:115900615-115900810 Neighboring gene Sharpr-MPRA regulatory region 5302 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:115920203-115920404 Neighboring gene solute carrier family 31 member 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:115949815-115951014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28835 Neighboring gene solute carrier family 31 member 1 Neighboring gene uncharacterized LOC107987119 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116036963-116037818 Neighboring gene cell division cycle 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. Viklund IM, et al. Exp Cell Res, 2009 Apr 1. PMID 19121306
  2. Identification of a new WASP and FKBP-like (WAFL) protein in inflammatory bowel disease: a potential marker gene for ulcerative colitis. Viklund IM, et al. Int J Colorectal Dis, 2008 Oct. PMID 18654788
  3. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. Nakajima O, et al. Biochem Biophys Res Commun, 2006 Jul 21. PMID 16756961
  4. The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis. Pan YF, et al. Int J Biol Sci, 2010 Mar 29. PMID 20376207, Free PMC Article
  5. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Harbour ME, et al. Biochem J, 2012 Feb 15. PMID 22070227

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings are compatible with a model whereby WAFL is involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.
    Title: WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.
  2. WAFL may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033
    Title: The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FK506-binding protein 15
Names
133 kDa FK506-binding protein
133 kDa FKBP
FK506 binding protein 15, 133kDa
FK506-binding protein 133kDa
FKBP prolyl isomerase 15
FKBP-133
FKBP-15
WAFL
WASP and FKBP-like protein
protein phosphatase 1, regulatory subunit 76
NP_056073.1
XP_006717081.1
XP_006717082.1
XP_054218510.1
XP_054218511.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015258.2 → NP_056073.1  FK506-binding protein 15

    See identical proteins and their annotated locations for NP_056073.1

    Status: VALIDATED

    Source sequence(s)
    AB014574, AL449105, BC077732, BQ646813, DA238568
    Consensus CDS
    CCDS48007.1
    UniProtKB/Swiss-Prot
    Q05DK8, Q5T1M2, Q5T1M5, Q6DD85, Q9Y4D0
    UniProtKB/TrEMBL
    A0A8I5QJL3
    Related
    ENSP00000238256.3, ENST00000238256.8
    Conserved Domains (8) summary
    COG1340
    Location:511 → 781
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam05029
    Location:589 → 777
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:193 → 286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:715 → 780
    Ax_dynein_light; Axonemal dynein light chain
    pfam14988
    Location:694 → 871
    DUF4515; Domain of unknown function (DUF4515)
    cl00599
    Location:1014 → 1072
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:686 → 908
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:70 → 168
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113161006..113221277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717019.2 → XP_006717082.1  FK506-binding protein 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5QJL3
    Conserved Domains (8) summary
    pfam05029
    Location:521 → 709
    TIMELESS_C; Timeless protein C terminal region
    pfam00254
    Location:125 → 218
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:647 → 712
    Ax_dynein_light; Axonemal dynein light chain
    pfam12795
    Location:588 → 807
    MscS_porin; Mechanosensitive ion channel porin domain
    pfam14662
    Location:465 → 677
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl00599
    Location:946 → 1004
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:618 → 840
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:2 → 100
    PH-like; Pleckstrin homology-like domain

  2. XM_006717018.3 → XP_006717081.1  FK506-binding protein 15 isoform X1

    UniProtKB/TrEMBL
    A0A8I5QJL3
    Related
    ENSP00000509797.1, ENST00000687395.1
    Conserved Domains (9) summary
    pfam00254
    Location:193 → 286
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam10211
    Location:705 → 770
    Ax_dynein_light; Axonemal dynein light chain
    pfam13863
    Location:645 → 738
    DUF4200; Domain of unknown function (DUF4200)
    pfam14988
    Location:684 → 861
    DUF4515; Domain of unknown function (DUF4515)
    pfam15619
    Location:578 → 770
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl00599
    Location:1004 → 1062
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
    cl02488
    Location:676 → 898
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:514 → 700
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17171
    Location:70 → 168
    PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125359842..125420103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362536.1 → XP_054218511.1  FK506-binding protein 15 isoform X2

  2. XM_054362535.1 → XP_054218510.1  FK506-binding protein 15 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T1M5.2 GenPept UniProtKB/Swiss-Prot:Q5T1M5

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