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TMEM131L transmembrane 131 like [ Homo sapiens (human) ]

Gene ID: 23240, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM131Lprovided by HGNC
Official Full Name
transmembrane 131 likeprovided by HGNC
Primary source
HGNC:HGNC:29146
See related
Ensembl:ENSG00000121210 MIM:616243; AllianceGenome:HGNC:29146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0922
Summary
Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 22.3), bone marrow (RPKM 15.4) and 22 other tissues See more
Orthologs
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Genomic context

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See TMEM131L in Genome Data Viewer
Location:
4q31.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153466360..153636711)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156790800..156961149)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154387512..154557863)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. Maharzi N, et al. J Immunol, 2013 Jun 15. PMID 23690469
  2. Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression. Szuplewski S, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28347816
  3. Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination. Fan X, et al. Int J Mol Sci, 2021 Sep 28. PMID 34638806, Free PMC Article
  4. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. Navare AT, et al. J Cell Biol, 2022 Nov 7. PMID 36305789, Free PMC Article
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Low SK, et al. Cancer Sci, 2013 Aug. PMID 23648065, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of KIAA0922 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with KIAA0922 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10592, DKFZp586H1322

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131007.2 → NP_001124479.1  transmembrane protein 131-like isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK092270, AK096538, AK308448, BC044932
    Consensus CDS
    CCDS47148.1
    UniProtKB/TrEMBL
    H0Y2M0
    Related
    ENSP00000386787.3, ENST00000409959.8
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  2. NM_015196.4 → NP_056011.3  transmembrane protein 131-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_056011.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC131505, BQ270562, DA778851
    Consensus CDS
    CCDS3783.2
    UniProtKB/Swiss-Prot
    A2VDJ0, B3KRV3, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
    UniProtKB/TrEMBL
    H0Y2M0
    Related
    ENSP00000386574.3, ENST00000409663.7
    Conserved Domains (2) summary
    pfam19532
    Location:185 → 1609
    TMEM131_like; Transmembrane protein 131-like
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    153466360..153636711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449899.1 → XP_047305855.1  transmembrane protein 131-like isoform X1

  2. XM_011531780.2 → XP_011530082.1  transmembrane protein 131-like isoform X4

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120 → 203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  3. XM_047449901.1 → XP_047305857.1  transmembrane protein 131-like isoform X3

  4. XM_047449902.1 → XP_047305858.1  transmembrane protein 131-like isoform X6

  5. XM_047449917.1 → XP_047305873.1  transmembrane protein 131-like isoform X25

  6. XM_011531783.2 → XP_011530085.1  transmembrane protein 131-like isoform X28

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120 → 203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  7. XM_047449920.1 → XP_047305876.1  transmembrane protein 131-like isoform X29

  8. XM_047449900.1 → XP_047305856.1  transmembrane protein 131-like isoform X2

  9. XM_011531781.2 → XP_011530083.1  transmembrane protein 131-like isoform X5

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120 → 203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  10. XM_047449903.1 → XP_047305859.1  transmembrane protein 131-like isoform X7

  11. XM_047449918.1 → XP_047305874.1  transmembrane protein 131-like isoform X26

  12. XM_047449919.1 → XP_047305875.1  transmembrane protein 131-like isoform X27

  13. XM_047449904.1 → XP_047305860.1  transmembrane protein 131-like isoform X8

  14. XM_047449908.1 → XP_047305864.1  transmembrane protein 131-like isoform X14

  15. XM_047449909.1 → XP_047305865.1  transmembrane protein 131-like isoform X15

  16. XM_047449905.1 → XP_047305861.1  transmembrane protein 131-like isoform X9

  17. XM_047449910.1 → XP_047305866.1  transmembrane protein 131-like isoform X16

  18. XM_024453956.2 → XP_024309724.1  transmembrane protein 131-like isoform X10

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  19. XM_047449906.1 → XP_047305862.1  transmembrane protein 131-like isoform X11

  20. XM_017007925.2 → XP_016863414.1  transmembrane protein 131-like isoform X17

    UniProtKB/TrEMBL
    H0Y2M0

  21. XM_047449921.1 → XP_047305877.1  transmembrane protein 131-like isoform X30

  22. XM_047449923.1 → XP_047305879.1  transmembrane protein 131-like isoform X32

    Related
    ENSP00000240487.5, ENST00000240487.5

  23. XM_047449925.1 → XP_047305881.1  transmembrane protein 131-like isoform X34

  24. XM_024453957.2 → XP_024309725.1  transmembrane protein 131-like isoform X12

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  25. XM_047449907.1 → XP_047305863.1  transmembrane protein 131-like isoform X13

  26. XM_017007926.2 → XP_016863415.1  transmembrane protein 131-like isoform X18

    UniProtKB/TrEMBL
    H0Y2M0

  27. XM_047449922.1 → XP_047305878.1  transmembrane protein 131-like isoform X31

  28. XM_047449924.1 → XP_047305880.1  transmembrane protein 131-like isoform X33

  29. XM_047449926.1 → XP_047305882.1  transmembrane protein 131-like isoform X35

  30. XM_047449911.1 → XP_047305867.1  transmembrane protein 131-like isoform X19

  31. XM_047449913.1 → XP_047305869.1  transmembrane protein 131-like isoform X21

  32. XM_047449915.1 → XP_047305871.1  transmembrane protein 131-like isoform X23

  33. XM_047449927.1 → XP_047305883.1  transmembrane protein 131-like isoform X36

  34. XM_047449912.1 → XP_047305868.1  transmembrane protein 131-like isoform X20

  35. XM_047449914.1 → XP_047305870.1  transmembrane protein 131-like isoform X22

  36. XM_047449916.1 → XP_047305872.1  transmembrane protein 131-like isoform X24

  37. XM_047449928.1 → XP_047305884.1  transmembrane protein 131-like isoform X37

  38. XM_047449929.1 → XP_047305885.1  transmembrane protein 131-like isoform X38

  39. XM_047449930.1 → XP_047305886.1  transmembrane protein 131-like isoform X39

  40. XM_024453958.2 → XP_024309726.1  transmembrane protein 131-like isoform X40

    UniProtKB/TrEMBL
    B3KU55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    156790800..156961149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349416.1 → XP_054205391.1  transmembrane protein 131-like isoform X1

  2. XM_054349419.1 → XP_054205394.1  transmembrane protein 131-like isoform X4

  3. XM_054349425.1 → XP_054205400.1  transmembrane protein 131-like isoform X10

  4. XM_054349426.1 → XP_054205401.1  transmembrane protein 131-like isoform X11

  5. XM_054349432.1 → XP_054205407.1  transmembrane protein 131-like isoform X17

  6. XM_054349445.1 → XP_054205420.1  transmembrane protein 131-like isoform X30

  7. XM_054349447.1 → XP_054205422.1  transmembrane protein 131-like isoform X32

  8. XM_054349449.1 → XP_054205424.1  transmembrane protein 131-like isoform X34

  9. XM_054349427.1 → XP_054205402.1  transmembrane protein 131-like isoform X12

  10. XM_054349428.1 → XP_054205403.1  transmembrane protein 131-like isoform X13

  11. XM_054349433.1 → XP_054205408.1  transmembrane protein 131-like isoform X18

  12. XM_054349446.1 → XP_054205421.1  transmembrane protein 131-like isoform X31

  13. XM_054349448.1 → XP_054205423.1  transmembrane protein 131-like isoform X33

  14. XM_054349450.1 → XP_054205425.1  transmembrane protein 131-like isoform X35

  15. XM_054349434.1 → XP_054205409.1  transmembrane protein 131-like isoform X19

  16. XM_054349436.1 → XP_054205411.1  transmembrane protein 131-like isoform X21

  17. XM_054349438.1 → XP_054205413.1  transmembrane protein 131-like isoform X23

  18. XM_054349451.1 → XP_054205426.1  transmembrane protein 131-like isoform X36

  19. XM_054349435.1 → XP_054205410.1  transmembrane protein 131-like isoform X20

  20. XM_054349437.1 → XP_054205412.1  transmembrane protein 131-like isoform X22

  21. XM_054349439.1 → XP_054205414.1  transmembrane protein 131-like isoform X24

  22. XM_054349452.1 → XP_054205427.1  transmembrane protein 131-like isoform X37

  23. XM_054349418.1 → XP_054205393.1  transmembrane protein 131-like isoform X3

  24. XM_054349421.1 → XP_054205396.1  transmembrane protein 131-like isoform X6

  25. XM_054349453.1 → XP_054205428.1  transmembrane protein 131-like isoform X38

  26. XM_054349454.1 → XP_054205429.1  transmembrane protein 131-like isoform X39

  27. XM_054349440.1 → XP_054205415.1  transmembrane protein 131-like isoform X25

  28. XM_054349443.1 → XP_054205418.1  transmembrane protein 131-like isoform X28

  29. XM_054349444.1 → XP_054205419.1  transmembrane protein 131-like isoform X29

  30. XM_054349420.1 → XP_054205395.1  transmembrane protein 131-like isoform X5

  31. XM_054349417.1 → XP_054205392.1  transmembrane protein 131-like isoform X2

  32. XM_054349422.1 → XP_054205397.1  transmembrane protein 131-like isoform X7

  33. XM_054349441.1 → XP_054205416.1  transmembrane protein 131-like isoform X26

  34. XM_054349442.1 → XP_054205417.1  transmembrane protein 131-like isoform X27

  35. XM_054349423.1 → XP_054205398.1  transmembrane protein 131-like isoform X8

  36. XM_054349429.1 → XP_054205404.1  transmembrane protein 131-like isoform X14

  37. XM_054349430.1 → XP_054205405.1  transmembrane protein 131-like isoform X15

  38. XM_054349424.1 → XP_054205399.1  transmembrane protein 131-like isoform X9

  39. XM_054349431.1 → XP_054205406.1  transmembrane protein 131-like isoform X16

  40. XM_054349455.1 → XP_054205430.1  transmembrane protein 131-like isoform X41

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VDJ0.2 GenPept UniProtKB/Swiss-Prot:A2VDJ0

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