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SYNE2 spectrin repeat containing nuclear envelope protein 2 [ Homo sapiens (human) ]

Gene ID: 23224, updated on 7-Apr-2024

Summary

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Official Symbol
SYNE2provided by HGNC
Official Full Name
spectrin repeat containing nuclear envelope protein 2provided by HGNC
Primary source
HGNC:HGNC:17084
See related
Ensembl:ENSG00000054654 MIM:608442; AllianceGenome:HGNC:17084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUA; EDMD5; KASH2; Nesp2; TROPH; NUANCE; SYNE-2; Nesprin-2
Summary
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in skin (RPKM 13.7), kidney (RPKM 12.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q23.2
Exon count:
125
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63761596..64226449)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57969282..58434164)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64319722..64693167)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8517 Neighboring gene RNA, U7 small nuclear 116 pseudogene Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8518 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene14 Neighboring gene ribosomal protein S28 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8521 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_35084 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64357721-64358428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64360139-64360663 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_35093 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_35095 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64417577-64418140 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64418141-64418703 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:64503774-64504468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64526989-64527584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64540907-64541408 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:64581878-64582065 Neighboring gene microRNA 548h-1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64649031-64649892 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:64652879-64653670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64663246-64663842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64691697-64692198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64692199-64692698 Neighboring gene uncharacterized LOC124903328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8525 Neighboring gene estrogen receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8526 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64805694-64806376 Neighboring gene testis expressed 21, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch. Xu Q, et al. Int Wound J, 2022 Aug. PMID 34558192, Free PMC Article
  2. A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy. Lee SJ, et al. Clin Chim Acta, 2020 Jul. PMID 32184094
  3. Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells. Liggett JL, et al. Biochim Biophys Acta, 2014 Jan. PMID 24080406, Free PMC Article
  4. Nesprin-2 epsilon: a novel nesprin isoform expressed in human ovary and Ntera-2 cells. Lam le T, et al. Biochem Biophys Res Commun, 2011 Aug 26. PMID 21820406
  5. Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Libotte T, et al. Mol Biol Cell, 2005 Jul. PMID 15843432, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.
    Title: Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.
  2. Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.
    Title: Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.
  3. Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch.
    Title: Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch.
  4. Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.
    Title: Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.
  5. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
  6. A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy.
    Title: A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy.
  7. Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.
    Title: Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.
  8. Results indicate that sperm associated antigen 4 (SPAG4L/SPAG4Lbeta) transcript isoform interacts with spectrin repeat containing nuclear envelope protein 2 (Nesprin2) in the meiotic process.
    Title: SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis.
  9. CRISPR/Cas9-mediated knockout of Syne-2 in cell culture led to an overexpression and mislocalization of Pcnt and to ciliogenesis defects. This suggests that the Pcnt-Syne-2 complex is important for ciliogenesis and outer segment formation during retinal development and plays a role in nuclear migration.
    Title: Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.
  10. Study shows that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. This response requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1.
    Title: LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Emery-Dreifuss muscular dystrophy 5, autosomal dominant
MedGen: C2751805 OMIM: 612999 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11014, FLJ43727, FLJ45710, FLJ46790, KIAA1011, DKFZp434H2235, DKFZp686H1931, DKFZp686E01115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeleton-nuclear membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration along microfilament ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in filopodium membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in lamellipodium membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nesprin-2
Names
KASH domain-containing protein 2
nesprin 2
nuclear envelope spectrin repeat protein 2
nucleus and actin connecting element protein
polytrophin
spectrin repeat containing, nuclear envelope 2
synaptic nuclear envelope protein 2
synaptic nuclei expressed gene 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011756.2 RefSeqGene

    Range
    96106..469535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_872

mRNA and Protein(s)

  1. NM_015180.6 → NP_055995.4  nesprin-2 isoform 1

    See identical proteins and their annotated locations for NP_055995.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.
    Source sequence(s)
    AF435011, AF495911, AI685725, AL355094, DB271849
    Consensus CDS
    CCDS41963.1
    UniProtKB/Swiss-Prot
    B4DND7, B4DPR6, I6XXQ5, Q540G1, Q86YP9, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH0, Q8WXH1, Q9UFQ4, Q9Y2L4, Q9Y4R1
    UniProtKB/TrEMBL
    G3V5X4
    Related
    ENSP00000341781.4, ENST00000344113.8
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6854 → 6885
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. NM_182910.2 → NP_878914.1  nesprin-2 isoform 2

    See identical proteins and their annotated locations for NP_878914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (2) is shorter at the N-terminus compared to isoform 5.
    Source sequence(s)
    AI685725, AY184204
    UniProtKB/Swiss-Prot
    Q8WXH0
    Related
    ENST00000441438.2
    Conserved Domains (2) summary
    cd00176
    Location:84 → 307
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:398 → 429
    KASH; Nuclear envelope localization domain

  3. NM_182913.4 → NP_878917.1  nesprin-2 isoform 4

    See identical proteins and their annotated locations for NP_878917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (4) is shorter at the N-terminus compared to isoform 5.
    Source sequence(s)
    AI685725, AL355094, AY061758
    Consensus CDS
    CCDS45124.1
    UniProtKB/Swiss-Prot
    Q8WXH0
    Related
    ENSP00000391937.2, ENST00000458046.6
    Conserved Domains (2) summary
    cd00176
    Location:210 → 433
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:525 → 556
    KASH; Nuclear envelope localization domain

  4. NM_182914.3 → NP_878918.2  nesprin-2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AL162832, AL355094, AL359235
    Consensus CDS
    CCDS9761.2
    UniProtKB/TrEMBL
    G3V5X4
    Related
    ENSP00000450831.2, ENST00000555002.6
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6876 → 6907
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    63761596..64226449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431152.1 → XP_047287108.1  nesprin-2 isoform X1

  2. XM_011536576.3 → XP_011534878.1  nesprin-2 isoform X1

    See identical proteins and their annotated locations for XP_011534878.1

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6905 → 6936
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_047431149.1 → XP_047287105.1  nesprin-2 isoform X1

  4. XM_011536574.2 → XP_011534876.1  nesprin-2 isoform X1

    See identical proteins and their annotated locations for XP_011534876.1

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6905 → 6936
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_011536578.2 → XP_011534880.1  nesprin-2 isoform X2

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6904 → 6935
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_011536579.2 → XP_011534881.1  nesprin-2 isoform X3

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6891 → 6922
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_011536580.3 → XP_011534882.1  nesprin-2 isoform X6

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6890 → 6921
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_005267454.2 → XP_005267511.1  nesprin-2 isoform X4

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6891 → 6922
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_005267456.2 → XP_005267513.1  nesprin-2 isoform X5

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6890 → 6921
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_005267457.2 → XP_005267514.1  nesprin-2 isoform X9

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6877 → 6908
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_011536581.2 → XP_011534883.1  nesprin-2 isoform X7

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6882 → 6913
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_047431153.1 → XP_047287109.1  nesprin-2 isoform X8

  13. XM_047431154.1 → XP_047287110.1  nesprin-2 isoform X11

  14. XM_047431156.1 → XP_047287112.1  nesprin-2 isoform X13

  15. XM_005267458.2 → XP_005267515.1  nesprin-2 isoform X10

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6868 → 6899
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  16. XM_047431155.1 → XP_047287111.1  nesprin-2 isoform X12

  17. XM_005267459.2 → XP_005267516.1  nesprin-2 isoform X15

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6853 → 6884
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  18. XM_011536582.2 → XP_011534884.1  nesprin-2 isoform X14

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2417
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6098 → 6311
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6866 → 6897
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5139 → 5345
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  19. XM_047431157.1 → XP_047287113.1  nesprin-2 isoform X16

  20. XM_047431158.1 → XP_047287114.1  nesprin-2 isoform X17

  21. XM_011536577.3 → XP_011534879.1  nesprin-2 isoform X1

    See identical proteins and their annotated locations for XP_011534879.1

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6905 → 6936
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  22. XM_047431159.1 → XP_047287115.1  nesprin-2 isoform X18

  23. XM_011536584.3 → XP_011534886.1  nesprin-2 isoform X19

    Conserved Domains (5) summary
    COG1196
    Location:2873 → 3746
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    TIGR02168
    Location:1898 → 2639
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    cl02488
    Location:1840 → 2031
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  24. XM_047431151.1 → XP_047287107.1  nesprin-2 isoform X1

  25. XM_047431150.1 → XP_047287106.1  nesprin-2 isoform X1

  26. XM_011536575.3 → XP_011534877.1  nesprin-2 isoform X1

    See identical proteins and their annotated locations for XP_011534877.1

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6905 → 6936
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  27. XM_017021101.2 → XP_016876590.1  nesprin-2 isoform X1

    UniProtKB/TrEMBL
    G3V5X4
    Conserved Domains (7) summary
    COG0419
    Location:3298 → 3912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    PRK03918
    Location:1868 → 2369
    PRK03918; chromosome segregation protein; Provisional
    cd00014
    Location:33 → 135
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:6137 → 6350
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:182 → 281
    CH; Calponin homology (CH) domain
    pfam10541
    Location:6905 → 6936
    KASH; Nuclear envelope localization domain
    cl02488
    Location:5178 → 5384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  28. XM_047431160.1 → XP_047287116.1  nesprin-2 isoform X20

    Related
    ENST00000394768.6

  29. XM_017021103.3 → XP_016876592.1  nesprin-2 isoform X21

    UniProtKB/TrEMBL
    Q6MZP0

  30. XM_017021104.3 → XP_016876593.1  nesprin-2 isoform X22

    UniProtKB/TrEMBL
    Q6MZP0

  31. XM_047431161.1 → XP_047287117.1  nesprin-2 isoform X23

    Related
    ENST00000555022.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    57969282..58434164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375667.1 → XP_054231642.1  nesprin-2 isoform X1

  2. XM_054375672.1 → XP_054231647.1  nesprin-2 isoform X1

  3. XM_054375669.1 → XP_054231644.1  nesprin-2 isoform X1

  4. XM_054375666.1 → XP_054231641.1  nesprin-2 isoform X1

  5. XM_054375674.1 → XP_054231649.1  nesprin-2 isoform X2

  6. XM_054375675.1 → XP_054231650.1  nesprin-2 isoform X3

  7. XM_054375678.1 → XP_054231653.1  nesprin-2 isoform X6

  8. XM_054375676.1 → XP_054231651.1  nesprin-2 isoform X4

  9. XM_054375677.1 → XP_054231652.1  nesprin-2 isoform X5

  10. XM_054375681.1 → XP_054231656.1  nesprin-2 isoform X9

  11. XM_054375679.1 → XP_054231654.1  nesprin-2 isoform X7

  12. XM_054375680.1 → XP_054231655.1  nesprin-2 isoform X8

  13. XM_054375683.1 → XP_054231658.1  nesprin-2 isoform X11

  14. XM_054375685.1 → XP_054231660.1  nesprin-2 isoform X13

  15. XM_054375682.1 → XP_054231657.1  nesprin-2 isoform X10

  16. XM_054375684.1 → XP_054231659.1  nesprin-2 isoform X12

  17. XM_054375687.1 → XP_054231662.1  nesprin-2 isoform X15

  18. XM_054375686.1 → XP_054231661.1  nesprin-2 isoform X14

  19. XM_054375688.1 → XP_054231663.1  nesprin-2 isoform X16

  20. XM_054375689.1 → XP_054231664.1  nesprin-2 isoform X17

  21. XM_054375690.1 → XP_054231665.1  nesprin-2 isoform X18

  22. XM_054375673.1 → XP_054231648.1  nesprin-2 isoform X1

  23. XM_054375671.1 → XP_054231646.1  nesprin-2 isoform X1

  24. XM_054375668.1 → XP_054231643.1  nesprin-2 isoform X1

  25. XM_054375670.1 → XP_054231645.1  nesprin-2 isoform X1

  26. XM_054375691.1 → XP_054231666.1  nesprin-2 isoform X24

  27. XM_054375692.1 → XP_054231667.1  nesprin-2 isoform X20

  28. XM_054375693.1 → XP_054231668.1  nesprin-2 isoform X21

  29. XM_054375694.1 → XP_054231669.1  nesprin-2 isoform X22

  30. XM_054375695.1 → XP_054231670.1  nesprin-2 isoform X23

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182912.1: Suppressed sequence

    Description
    NM_182912.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXH0.3 GenPept UniProtKB/Swiss-Prot:Q8WXH0

Gene LinkOut

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